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Identification of a Dps contamination in Mitomycin-C–induced expression of Colicin Ia
2021, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :MMC was also shown to act as an oxidizing reagent. MMC gets reduced in presence of an oxygen and generates hydrogen peroxide [39]. Upon MMC treatment of E. coli cells in their exponential phase, expectedly, proteins that protect the cell from the oxidative stress like two catalases KatE and KatG [40] as well as DNA-binding protein from starved cells (Dps) [41,42] were found up-regulated on the transcriptional level [43].
Replisome structure suggests mechanism for continuous fork progression and post-replication repair
2019, DNA RepairCitation Excerpt :Shortly afterward, DNA was successfully copied in the test tube with DNA polymerase I (Pol I) purified from E. coli by Arthur Kornberg’s lab [2,3]. In the ensuing two decades, DNA was shown to be susceptible to ultraviolet light (UV) damage, chemical adducts, oxidation and ionization radiation, and lesions caused by these damaging agents were thought to block DNA replication and induce the “SOS” response [4–10]. However, in 1968 Rupp and Howard-Flanders showed that replication is only slowed down but not blocked by unrepaired UV lesions, and in the presence of UV lesions replication products are shorter than usual and their lengths roughly match the distances between lesions [11].
Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay
2006, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisElectrochemical genosensor for Mitomycin C-DNA interaction based on guanine signal
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