The effect of a conditioning lesion on sudomotor axon regeneration
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Cited by (9)
Macrophage biology in the peripheral nervous system after injury
2019, Progress in NeurobiologyCitation Excerpt :This conditioning lesion effect was shown to occur in both sensory and motor axons (McQuarrie, 1978; McQuarrie et al., 1977). McQuarrie et al. (1978) reported that, in contrast, the rate of regeneration actually decreases in sympathetic axons in the sciatic; however, a later study on sympathetic-cholinergic axons that innervate the sweat gland established that these neurons do show acceleration of regeneration after a conditioning lesion (Navarro and Kennedy, 1990). Though conditioning lesion experiments were initially performed entirely in vivo, the effect of an in vivo conditioning lesion can subsequently be studied in either explant or dissociated cell culture.
The neuroimmunology of degeneration and regeneration in the peripheral nervous system
2015, NeuroscienceCitation Excerpt :Several groups have confirmed marked increases in neurite outgrowth after a CL in explants of DRG and SCG (Edstrom et al., 1996; Shoemaker et al., 2005; Sachs et al., 2007; Niemi et al., 2013), and in dissociated neuron cultures of those ganglia (Hu-Tsai et al., 1994; White et al., 1996; Smith and Skene, 1997; Shoemaker et al., 2005; Sachs et al., 2007; Niemi et al., 2013). Additionally, in vivo regeneration studies established that a CL response occurs in motor, sensory and sympathetic neurons (McQuarrie et al., 1977; McQuarrie, 1978; Navarro and Kennedy, 1990). It is important to note that in DRG neurons, which have both a peripheral and a central branch, a CL is produced only after a lesion of the peripheral branch (e.g. Smith and Skene, 1997; Seijffers et al., 2007).
STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration
2013, Molecular and Cellular NeuroscienceCitation Excerpt :These cytokines act via the gp130 receptor (Ip et al., 1992; Taga and Kishimoto, 1997) to promote axon regeneration in the central and peripheral nervous systems (Cafferty et al., 2001; Ekstrom et al., 2000; Homs et al., 2011; Leibinger et al., 2009). In sympathetic neurons cytokines are involved in the “conditioning lesion” response whereby prior injury enhances the subsequent regeneration (Hyatt Sachs et al., 2010; McQuarrie and Grafstein, 1973; Navarro and Kennedy, 1990; Shoemaker et al., 2005). Cytokines are thought to enhance nerve regeneration after injury through stimulating transcription of regeneration associated genes via tyrosine phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) (Ben-Yaakov et al., 2012; Habecker et al., 2009; Lee et al., 2004; Liu and Snider, 2001; O'Brien and Nathanson, 2007; Qiu et al., 2005; Smith and Skene, 1997).
Prior collateral sprouting of sensory axons delays recovery of pain sensitivity after subsequent nerve crush
1996, Experimental NeurologyA Perspective on Electrical Stimulation and Sympathetic Regeneration in Peripheral Nerve Injuries
2024, Neurotrauma ReportsAn In Vitro Model for Conditioning Lesion Effect
2019, Cellular and Molecular Neurobiology