Platelet adenylate cyclase and phospholipase C activity in posttraumatic stress disorder
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Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder
2011, PsychoneuroendocrinologyCitation Excerpt :In addition, plasma NE/EPI responses to trauma-related stimuli were more pronounced in PTSD patients when compared to controls (McFall et al., 1990; Blanchard et al., 1991; Liberzon et al., 1999). Altered expression of platelet α2-adrenoreceptors (α2AR) (Perry et al., 1987; Gurguis et al., 1999) and altered platelet adenylate cyclase (AC) activity have also been reported in PTSD patients (Lerer et al., 1990; Weizmann et al., 1994). The findings of increased α2AR density in PTSD (Gurguis et al., 1999) are consistent with enhanced EPI-mediated inhibition of forskolin-stimulated AC (Weizmann et al., 1994) and suggest that platelets from PTSD patients may be more reactive to EPI.
Brain, behavior, mental stress, and the neurocardiac interaction
2002, Journal of Nuclear CardiologyAbsence of reduced platelet adenylate cyclase activity in Vietnam veterans with PTSD
1995, Biological PsychiatryLymphocyte β-adrenergic receptors in panic disorder: Findings with a highly selective ligand and relationship to clinical parameters
1993, Journal of Anxiety DisordersPsychoneuroendocrine assessment of posttraumatic stress disorder: Current progress and new directions
1993, Progress in Neuropsychopharmacology and Biological Psychiatry
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