Elsevier

Biological Psychiatry

Volume 27, Issue 7, 1 April 1990, Pages 735-740
Biological Psychiatry

Platelet adenylate cyclase and phospholipase C activity in posttraumatic stress disorder

https://doi.org/10.1016/0006-3223(90)90588-SGet rights and content

Abstract

Adenylate cyclase and phospholipase C activity were examined in platelet membranes obtained from 19 male subjects with combat-related posttraumatic stress disorder (PTSD) and 35 age- and gender-matched healthy controls. Basal and forskolin-stimulated adenylate cyclase activity were significantly lower in the PTSD group whereas aluminum chloride plus sodium fluoride (AlCl3/NaF)- and prostaglandin E1 (PGE1)-stimulated responses were normal. There was no difference in phospholipase C activity between the two groups. The lower basal and forskolin-stimulated adenylate cyclase responses replicate a previous report and suggest that PTSD may be associated with an abnormality of the catalytic subunit of the receptor-adenylate cyclase complex.

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    Citation Excerpt :

    In addition, plasma NE/EPI responses to trauma-related stimuli were more pronounced in PTSD patients when compared to controls (McFall et al., 1990; Blanchard et al., 1991; Liberzon et al., 1999). Altered expression of platelet α2-adrenoreceptors (α2AR) (Perry et al., 1987; Gurguis et al., 1999) and altered platelet adenylate cyclase (AC) activity have also been reported in PTSD patients (Lerer et al., 1990; Weizmann et al., 1994). The findings of increased α2AR density in PTSD (Gurguis et al., 1999) are consistent with enhanced EPI-mediated inhibition of forskolin-stimulated AC (Weizmann et al., 1994) and suggest that platelets from PTSD patients may be more reactive to EPI.

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