Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative: Similarity with the oxidation of arginine to citrulline and nitric oxide
References (55)
- et al.
Hepatic microsomal N-demethylation of N-methylbenzamidine. N-Dealkylation vs N-oxygenation of amidines
Biochem Pharmacol
(1987) - et al.
Polymorphic hydroxylation of debrisoquine in man
Lancet
(1977) - et al.
: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery
Biochem Biophys Res Commun
(1991) - et al.
Induction of liver cytochrome P-450 in mice by warfarin
Biochem Pharmacol
(1985) - et al.
Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography
J Biol Chem
(1976) - et al.
The rabbit pulmonary monooxygenase system
J Biol Chem
(1979) - et al.
Hepatic microsomal mixed-function amino oxidase
- et al.
Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver
J Biol Chem
(1962) - et al.
Determination of serum proteins by means of the biuret reaction
J Biol Chem
(1949) - et al.
Measurement of protein using bicinchonic acid
Anal Biochem
(1985)
Assay of debrisoquine and 4-hydroxydebrisoquine in urine by reversed-phase high-performance liquid chromatography using online sample clean-up on a standard isocratic chromatograph
J Chromatogr
(1988)
Reduced pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes
Arch Biochem Biophys
(1973)
Cytochrome P-455 nm complex formation in the metabolism of phenyl-alkylamines. XI. Peroxygenase versus monooxygenase function of cytochrome P-450 in rat liver microsomes
Chem Biol Interact
(1990)
Chemical oxidation of N-hydroxyguanidine compounds. Release of nitric oxide, nitroxyl and possible relationship to the mechanism of biological nitric oxide generation
Biochem Pharmacol
(1992)
Species variations in the N-oxidation of chlorphentermine
Biochem Pharmacol
(1975)
Formation of nitrogen oxides and citrulline upon oxidation of by hemoproteins
Biochem Biophys Res Commun
(1992)
Cytochrome P450 catalyzes the oxidation of by NADPH and O2 to nitric oxide and citrulline
Biochem Biophys Res Commun
(1992)
Arzneimittelwirkungen
(1991)
Biotransformation stark basischer funktioneller Gruppen durch Stickstoffoxidation. Hochschulsammlung Naturwissenschaft
Chemie Pharmazie
(1985)
The oxidation of benzamidines in vitro
Xenobiotica
(1983)
New aspects of the microsomal N-hydroxylation of benzamidines
The in vitro oxygenation of N,N-diphenylguanidines
Xenobiotica
(1993)
In vitro Untersuchungen zur mikrosomalen N-oxidation einiger Guanidine
Arch Pharm (Weinheim)
(1986)
Metabolism of debrisoquine sulfate. Identification of some urinari metabolites in rat and man
Drug Met Dispos
(1975)
Hepatic microsomal cytochrome P-450-dependent N-demethylation of methylguanidine
Biochem Pharmacol
(1983)
Hydroxyguanidines. A new class of anti-hypertensive agents
J Med Chem
(1973)
Vascular endothelial cells synthesize nitric oxide from l-arginine
Nature
(1988)
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