Elsevier

Biochemical Pharmacology

Volume 41, Issue 11, 1 June 1991, Pages 1607-1614
Biochemical Pharmacology

Time course of IL-6 and TNFα release during endotoxin-induced endotoxin tolerance in rats

https://doi.org/10.1016/0006-2952(91)90161-WGet rights and content

Abstract

Development of endotoxin tolerance in rats induced by repeated application of low dosages of endotoxin is associated with repeatable IL-6 formation, reversible drop in white blood cells, pronounced consumption of platelets, gradual formation of α2M as an example of acute phase proteins, and flattening TNFα formation. In the status of full tolerance the TNF α release is completely eliminated. Inhibition of TNFα biosynthesis and induction of acute phase protein formation by IL-6 are discussed as possible factors in the development of endotoxin tolerance.

References (45)

  • G Tiegs et al.

    Leukocyte alterations do not account for hepatitis induced by endotoxin or TNFα in galactosamine-sensitized mice

    Biochem Pharmacol

    (1990)
  • CA Johnston et al.
  • AM Lefer

    Significance of lipid mediators in shock states

    Circ Shock

    (1989)
  • CA Dinarello

    Biology of Interleukin 1

    FASEB

    (1988)
  • CE Haak et al.

    Increased plasma levels of Interleukin-6 in sepsis

  • JG Cannon et al.

    Circulating Interleukin-1 and tumor necrosis in septic shock and experimental endotoxin fever

    J Infect. Dis

    (1990)
  • L Flohé et al.

    Endotoxins, arachidonic acid and superoxide formation

  • H Fritz et al.

    Granulocyte Proteinases as Mediators of Unspecific Proteolysis in Inflammation: A Review in Proteinases in Inflammation and Tumor Invasion

  • RL West et al.

    Blood coagulation factor activity in experimental endotoxemia

    Ann Surg

    (1966)
  • G Snedegard et al.

    Endotoxin induced shock in the rat. A role of C5a

    Am J Pathol

    (1989)
  • TM Carlos et al.

    Membrane proteins involved in phagocyte adherence to endothelium

    Immunol Rev

    (1990)
  • G Feuerstein et al.

    Effect of gram-negative endotoxin on levels on serum corticosterone, TNF-α, circulating blood cells, and the survival of rats

    Circ Shock

    (1990)

    • Cited by (0)

    View full text
    Copyright © 1991 Published by Elsevier Inc.