Biochemical and Biophysical Research Communications
Volume 184, Issue 2, 30 April 1992, Pages 752-759
Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity☆
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2011, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Understanding the pharmacology of 5-HT1B receptors is an important step in determining the physiological role of these receptors. Pharmacological studies have demonstrated that RU 24969 and trifluoromethyl-phenylpiperazine possess high affinity for 5-HT1B receptor binding sites in rodents, and that serotonergic agonist 5-CT has high affinity for both 5-HT1D and 5-HT1B receptor binding sites.153–155 Another agonist, CP 93129, demonstrates stronger affinity for 5-HT1B receptor binding sites over 5-HT1D receptors,156 whereas sumatriptan has a higher affinity for 5-HT1D receptor binding than for 5-HT1B receptors.28,157
Genetic Organization of the Serotonergic System
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. M89478.
Copyright © 1992 Published by Elsevier Inc.