Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Regular paperEffect of transforming growth factor-β on lipoprotein lipase in rat mesenchymal heart cell cultures
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Plasma tumour and metabolism related biomarkers AMBP, LPL and Glyoxalase I differentiate heart failure with preserved ejection fraction with pulmonary hypertension from pulmonary arterial hypertension
2021, International Journal of CardiologyCitation Excerpt :AMBP additionally correlated with PAWP, supporting the notion that it may be linked with diastolic dysfunction and may be able to differentiate post- from pre-capillary PH. Further studies are warranted to evaluate the influence of plasma AMBP elevation on A1M and bikunin levels in HFpEF-PH. Additionally, whether increased plasma AMBP counteract the pro-inflammatory milieu in HFpEF-PH through altered A1M and bikunin levels, remains to be elucidated. Fatty acids constitute the energy substrate primarily used in cardiomyocytes, and are delivered to the heart, among other mechanisms, through hydrolyzation of lipoprotein-triglycerides with LPL [31]. In HF, however, deranged metabolism of energy substrates occurs, leading to a shift from fatty acid to glucose utilization [32].
Lipoprotein lipase as a candidate target for cancer prevention/therapy
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