Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Effect of phosphatidylcholine and free fatty acids on the activity of pancreatic lipase-colipase
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Cited by (34)
Effects of dietary free fatty-acid content and saturation degree on lipid-class composition and fatty-acid digestibility along the gastrointestinal tract in broiler starter chickens
2019, Poultry ScienceCitation Excerpt :The lack of differences in both the digestibility coefficients and lipid-class content in the duodenum could be related to the presence of FFA in the diets, which are an end-product of the hydrolysis process and are not affected by pancreatic lipase activity. However, Larsson and Erlanson-Albertsson (1986) suggested that FFA could induce a high-affinity complex between lipase and colipase, and it could change the properties of the interface leading to an increased binding of lipase and colipase to the substrate; this effect has been especially attributed to lauric, oleic, and linolenic acids. On the other hand, a clear impact of the dietary FFA% on fat absorption was observed, which was supported by the lower TFA, SFA, MUFA, and PUFA (tendency) digestibility coefficients in the jejunum, and the lower SFA, and MUFA (tendency) digestibility coefficients in the ileum observed for the chickens fed the diets with the highest content of dietary FFA (50% FFA), in comparison to those fed the diets with the lowest content of dietary FFA (5% FFA) and, in some cases, with those fed the 15% FFA diets as well.
Fats in poultry nutrition: Digestive physiology and factors influencing their utilisation
2016, Animal Feed Science and TechnologyCitation Excerpt :As a result, unsaturated FA, which have an angle of approximately 141° at the site of double bond, have a greater ability to increase lipase activity compared to long chain saturated FA. The result being oleic (C18:1) and linoleic (C18:2) acids greatly increase lipase activity, whereas long chain saturated FA such as stearic acid (C18:0) have inhibitory effects (Larsson and Erlanson, 1981, 1986). The digestion of fat is greatly accelerated by the entry of digesta into the duodenum.
Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns
2011, Journal of Biological ChemistryCitation Excerpt :Thus, the partially digested dietary fats are suitable substrates for human PLRP2. Lag phases have been commonly observed for lipolytic enzymes in the hydrolysis of substrates in emulsions, liposomes, and monolayers (22–26). The increased activity following the lag phase is probably due to increased absorption of PTL and colipase to the substrate interface induced by fatty acids released during the lag phase (22, 27).
Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet
2010, FitoterapiaCitation Excerpt :One explanation for that is that ginsenosides on the surface of a triglyceride droplet mediated simply through disturbing the access of the lipase to the substrate rather than integrating the lipase molecule directly to inhibit lipase activity. Another presumption is that the effects on pancreatic lipase may depend on whether the removal of micellar phospholipid or the addition of mixed phosphatidyl choline-taurocholate micelles [38–40]. The difference in the structure of PTG and PDG is that a hydroxyl group attaches to 6-position in PTG, which might be the reason for their difference on the lipase activity.
Correlation between digestion of the lipid phase of smedds and release of the anti-HIV drug UC 781 and the anti-mycotic drug enilconazole from smedds
2007, European Journal of Pharmaceutics and BiopharmaceuticsActivation and inhibition of Candida rugosa and Bacillus-related lipases by saturated fatty acids, evaluated by a new colorimetric microassay
2004, Biochimica et Biophysica Acta - General Subjects