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2021, Journal of EndodonticsCitation Excerpt :Although EGCG is soluble in water, the aqueous form is not ideal for intracanal dressing because it is quickly absorbed by periapical tissues35. Thus, the proposed EGCG formulation used a viscous PEG 400 vehicle, which is a flexible polymer that was selected because it is biocompatible and allows the substance to be released slowly over an extended period of time36–38, allowing the paste to be retained for a longer time within the root canal, in addition to maintaining the stability of the material’s properties compared with the aqueous vehicle. In addition to the presence of the active ingredient (EGCG) and the vehicle (PEG 400), an intracanal dressing must present a radiopacifying agent (zinc oxide) so that it can be evidenced radiographically in order to assess complete root canal filling.
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Present address: Department of Biochemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1W5.