ADP-iron as a fenton reactant: Radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation
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2008, Journal of Inorganic BiochemistryCitation Excerpt :Therefore, here, 2-deoxy-ribose was a less efficient scavenger, as compared to DMPO, and reduced DMPO–OH adduct concentration by 25% at 2 mM DMPO and 2 mM 2-deoxy-ribose. A similar observation was made by Gutteridge who showed that at 50 mM DMPO and 50 mM 2-deoxy-ribose, the latter inhibited formation of the DMPO–OH adduct by 45% in phosphate buffer (pH 7.4) and 0.1 mM Fe(II) salt [43]. Likewise, adenosine inhibits radical production far less efficiently than ATP, with an IC50 value of 1.11 mM (IC90 is ≫4 mM).
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Permanent address: National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts, EN6 3QG,UK.
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Present address: Verzar International Laboratory for Experimental Gerontology (VILEG), Italian Section, Department of Gerontological Research, INRCA, Via Birarelli, 8.I-60121 ANCONA, Italy.