Inhibition of phospholipase A2 and phospholipase C by polyamines
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Reversible changes in goldfish brain polyamine concentrations and synthetic enzymes after cold exposure
2004, Brain ResearchCitation Excerpt :Specific membrane binding sites have been shown [13] through which polyamines regulate cell signaling. They have indeed been reported to modulate the activity of G-proteins, protein kinase C and phopholipases [4,10,46], to regulate ionic fluxes and neural ion channels [45], to control the Ca2+ homeostasis [47], and to prevent lipid peroxidation [33]. Polyamines modulate the NMDA receptor-complex and its associated second messenger pathways [41,55], and putrescine seems to be involved in stimulating neurotransmitter release from fish brain [23].
Inhibition of arterial thrombosis by polyamines in a canine coronary artery injury model
2003, Thrombosis ResearchEffect of polyamines on in vitro platelet aggregation and in vivo thrombus formation
2002, Cardiovascular Radiation MedicinePolycations induce the release of soluble intermembrane mitochondrial proteins
2001, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :Spermine is known to inhibit PTP and stabilize rather than destabilize, mitochondria, in vitro [30]. However, the latter effect is most likely due not only to spermine inhibition of PTP [23], but also to inhibition of phospholipases [31], which produce free fatty acids that activate PTP, and appear to be the main reason for the rapid deterioration of isolated mitochondria. We have ameliorated this in vitro artifact by including BSA in the incubation medium, which allowed us to detect the destabilizing effect of spermine, in vitro.
Relation between accumulation of phospholipase A<inf>2</inf> reaction products and Ca<sup>2+</sup> release in isolated liver mitochondria
1996, Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
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Present address: Istituto di Biochimica, Universitá di Ancona, Italy.