General obstetrics and gynecology
Pyelonephritis in pregnancy: Once-a-day ceftriaxone versus multiple doses of cefazolin: A randomized, double-blind trial

https://doi.org/10.1016/0002-9378(95)90100-0Get rights and content

Abstract

OBJECTIVE: The purpose of this study was to compare the efficacy of a single daily dose of intravenous ceftriaxone with that of multiple-dose cefazolin in the treatment of acute pyelonephritis in pregnancy.

STUDY DESIGN: This was a double-blind, randomized, clinical trial. Patients admitted to the hospital with the diagnosis of acute pyelonephritis in pregnancy were enrolled and randomized according to a computer-generated randomization schedule. The study group received a single daily 1 gm dose of ceftriazone intravenously along with two additional doses of normal saline solution. The comparison group received three daily 2 gm doses of cefazolin intravenously. All infusions were given on an 8-hour schedule. Treatments were continued until the patient became afebrile. Each patient was discharged from the hospital on a regimen of appropriate oral antibiotics as directed by urine culture and sensitivities. At follow-up visits test-of-cure cultures were obtained.

RESULTS: During the 2 year study period, 178 patients were randomized: 88 received cefazolin and 90 ceftriazone. Patient demographics and presenting signs and symptoms were similar in both groups. No differences were noted between the groups regarding days of febrile morbidity, length of hospital stay, or treatment failures.

CONCLUSIONS: Daily single-dose intravenous ceftriazone is as effective as multiple-dose cefazolin in the treatment of patients with acute pyelonephritis during pregnancy.

References (11)

  • LC Gilstrap et al.

    Acute pyelonephritis in pregnancy: an anterospective study

    Obstet Gynecol

    (1981)
  • S Dunlow et al.

    Prevalence of antibiotic-resistant uropathogens in obstetric patients with acute pyelonephritis

    Obstet Gynecol

    (1990)
  • SJ Childs et al.

    Ceftriaxone for once-a-day therapy of urinary tract infections

    Am J Med

    (1984)
  • DL Rothwell et al.

    Treatment of complicated urinary tract infections with the long acting cephalosporin, ceftriaxone

    N Z Med J

    (1983)
  • A Iravani et al.

    Single-dose ceftriaxone versus multiple-dose trimethoprin-sulfamethoxazole in the treatment of acute urinary tract infections

    Antimicrob Agents Chemother

    (1985)
There are more references available in the full text version of this article.

Cited by (0)

View full text