Clinical study
The importance of type IV hyperlipoproteinemia as a predisposing factor in coronary artery disease

https://doi.org/10.1016/0002-9343(74)90167-3Get rights and content

Abstract

One hundred seventy-six consecutive patients were evaluated for the frequency of potentially reversible risk factors associated with coronary artery disease. The results In a group of 105 patients with objective coronary artery disease was compared with a control group of 71 patients without coronary disease. The prevalence of risk factors was examined in the entire group of 176 patients and in a young subgroup of 55 patients with coronary disease who were under 50 years of age.

Obesity was the most prevalent risk factor for the whole group but was especially significant for the young patient with coronary disease. Type IV hyperlipoproteinemia, the most prevalent lipoprotein disorder in the study, was significantly elevated in the entire group as well as in the young patients with coronary disease. An abnormal glucose tolerance test was another feature of the young patients with coronary disease. Although some men with coronary disease did not have a predisposing metabolic abnormality, no woman in the study had coronary disease if a metabolic abnormality was not present. These findings emphasize the metabolic nature of coronary artery disease as well as the atherogenic potential of type IV hyperlipoproteinemia.

References (58)

  • S Dayton et al.

    Cholesterol, atherosclerosis, ischemic heart disease, and stroke

    Ann Intern Med

    (1970)
  • EMM Besterman

    Lipoproteins in coronary artery disease

    Br Heart J

    (1957)
  • MJ Albrink et al.

    Serum triglycerides in coronary artery disease

    Arch Intern Med

    (1959)
  • D Hayes et al.

    Serum cholesterol and triglycerides in ischemic heart disease

    Clin Sci

    (1964)
  • R Nicolaysen et al.

    Plasma lipids in coronary heart disease

    Scand J Clin Lab Invest

    (1963)
  • DF Brown et al.

    Serum triglycerides in health and in ischemic heart disease

    N Engl J Med

    (1965)
  • K Cramer et al.

    Coronary angiographic finding in correlation with age, body weight, blood pressure, serum lipids and smoking habits

    Circulation

    (1966)
  • PT Kuo

    Hyperglyceridemia in coronary artery disease and its management

    JAMA

    (1967)
  • DH Blankenhorn et al.

    Ischemic heart disease in young adults: metabolic and angiographic diagnosis and the prevalence of type IV hyperlipoproteinemia

    Ann Intern Med

    (1968)
  • PT Kuo

    Current metabolic-genetic interrelationship in human atherosclerosis with therapeutic considerations

    Ann Intern Med

    (1968)
  • WB Kannel et al.

    Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study

    Ann Intern Med

    (1971)
  • Serum cholesterol procedure N-24

  • G Kessler et al.

    Fluorometric measurements of triglycerides

  • RS Lees et al.

    Sharper separation of lipoprotein species by paper electrophoresis in albumin containing buffer

    J Lab Clin Med

    (1963)
  • RI Levy

    Classification and etiology of hyperlipoproteinemias

  • DS Fredrickson et al.

    A system for phenotyping hyperlipoproteinemia

    Circulation

    (1965)
  • DS Fredrickson et al.

    Fat transport in lipoproteins. An integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport in lipoproteins. An integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport in lipoproteins. An integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport in lipoproteins. An integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport in lipoproteins. An integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
  • DS Fredrickson et al.

    Familial hyperlipoproteinemia

  • JL Beaumont et al.

    Classification of hyperlipidemias and hyperlipoproteinemia

    Bull WHO

    (1970)
  • Cited by (42)

    • Obesity, body fat and coronary atherosclerosis

      2005, International Journal of Cardiology
    • 5. Epidemiology

      1991, The American Journal of Cardiology
    • The clinical utility of risk factor data

      1989, Journal of Clinical Epidemiology
    View all citing articles on Scopus

    This study was presented in part at the Annual Meeting of The American Heart Association, Anaheim, California, November 1971.

    1

    From the Laboratory of Clinical Physiology Section of Cardivascular Medicine, School of Medicine, University of California at Davis, Davis, California.

    Present address: Milton S. Hershey, Medical Center, Pennsylvania State University School of Medicine, Hershey, Pennsylvania 17033.

    View full text