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Multiple Functional Neuroendocrine Tumors of Pancreas and Duodenum Managed by Robotic Totally Duodenumpancreatectomy

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Abstract

Multiple endocrine neoplasia (MEN) syndrome type I is a rare genetic syndrome characterized by the growth of endocrine tumors in different organs, mostly endocrine glands. Zollinger-Ellison and organic hyperinsulinism can be a part of this syndrome but it is very rare when they can be observed together in one patient. Clinical case of MEN I was described. Symptoms, presented by hypoglycemia and multiple ulcers, occurred in a 42-year-old woman. She suffered for 9 years, the diagnosis was multiple neuroendocrine tumors of the pancreas and duodenum, organic hyperinsulinism, Zollinger-Ellison syndrome. Robotic total duodenumpancreatectomy, splenectomy, distal gastrectomy with D2 lymphadenectomy was performed. Postoperative recovery was uneventful; patient was discharged after less than 2 weeks. Long-term survival showed no recurrence of the disease. In reviewed literature, we found no other cases of synchronous hypoglycemic and Zollinger-Ellison syndromes managed by total robotic duodenumpancreatectomy. Robotic technology can become a feasible and preferable method of treatment even in such difficult cases.

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Data Availability

The data are not available for public access because of patient privacy concerns, but are available from the corresponding author on reasonable request.

Abbreviations

CT:

computed tomography

IC unit:

intensive care unit

HPF:

high presentative field

MEN I:

multiple endocrine neoplasia type I

NET:

neuroendocrine tumor

WHO:

World Health Organization

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Author information

Authors and Affiliations

  1. Abdominal Surgery Department, A.V. Vishnevsky centre of Surgery, 5 Universitetskiy prospect Street, 289, Moscow, Russian Federation, 119296

    A. G. Kriger

  2. Researcher of Abdominal Surgery Department, A.V. Vishnevsky Center of Surgery, 40 Seslavinskaya Street 48, Moscow, Russian Federation, 121309

    D. S. Gorin

  3. Leading Researcher of Abdominal Surgery Department, A.V. Vishnevsky Center of Surgery, 16/1 Solov’iniy proezd street 139, Moscow, Russian Federation, 117593

    S. V. Berelavichus

  4. Abdominal Surgery Department, A.V. Vishnevsky Center of Surgery, 40, Skobelevskaja street 70, Moscow, Russian Federation, 117624

    R. S. Dugarova

  5. Research of Pathologic anatomy Department, A.V. Vishnevsky Center of Surgery, 27, B. Serpuhovskaja, Moscow, Russian Federation, 117997

    O. V. Paklina

  6. Abdominal Surgery Department, A.V. Vishnevsky Center of Surgery, 3 Angelov pereylok 40, Moscow, Russian Federation, 125368

    V. I. Panteleev

  7. Surgeon of Abdominal Surgery Department, A.V. Vishnevsky Center of Surgery, 9, Novoe shosse street 78, Drojjino, Moscow region, Russian Federation, 142718

    A. R. Kaldarov

Authors
  1. A. G. Kriger
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  2. D. S. Gorin
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  3. S. V. Berelavichus
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  4. R. S. Dugarova
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  5. O. V. Paklina
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  6. V. I. Panteleev
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  7. A. R. Kaldarov
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Contributions

AGK and DSG designed the surgical concept and performed the surgery. SVB, ARK, RSD, and VIP carried out the acquisition of data and drafted the manuscript. OVP is responsible for the morphological part. AGK, DSG, SVB, ARK, and VIP revised the article. All authors read and approved the final manuscript.

Corresponding author

Correspondence to A. R. Kaldarov.

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Ethics Approval and Consent to Participate

The present study was conducted in accordance with the ethical standards of our institution.

Consent for Publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Competing Interests

The authors declare that they have no competing interests.

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Kriger, A.G., Gorin, D.S., Berelavichus, S.V. et al. Multiple Functional Neuroendocrine Tumors of Pancreas and Duodenum Managed by Robotic Totally Duodenumpancreatectomy. SN Compr. Clin. Med. 2, 675–680 (2020). https://doi.org/10.1007/s42399-020-00272-6

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  • DOI: https://doi.org/10.1007/s42399-020-00272-6

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