Abstract
Groundwater is one of the primary and most safe sources of freshwater supplies to sustain human life. Emerging contaminants (ECs) including pharmaceutical contaminants (PhACs), personal care products (PCPs), endocrine-disrupting compounds (EDCs), synthetic chemicals, and artificial sweeteners (ASWs) are detected in groundwater supplies in trace amounts, raising concerns about the possible adverse effects on humans and the ecosystem; thus, surveillance of contaminants is important to minimize risks. Therefore, this paper reviews more than 50 studies (2000–2020) that provide accurate and analytical information on PhACs and their composition in groundwater. In specific, detailed data on the occurrence and impact of ECs in various water body matrices are systematically analyzed and classified with respect to distinct groups (PhACs, PCPs, EDCs, ASWs, etc.). The main objective of this study is to (1) evaluate groundwater contamination via depicting occurrence and classification of PhACs as ECs, (2) analyze the health and ecological risk due to emerging PhACs, and (3) showcase challenges faced by industries and future prospects for further research on PhACs. The correlation between the occurrence of PhACs and their related health and ecological risks can be easily understood by this paper, which opens a new gateway to discover analytical strategies for future surveillance research works and to fill in the research gaps found in the existing state of knowledge on PhACs.
Similar content being viewed by others
Availability of data and material
All relevant data and material are presented in the main paper.
Abbreviations
- ECs:
-
emerging contaminants
- PhACs:
-
pharmaceutical contaminants
- PPCPs:
-
pharmaceuticals and personal care products
- PCPs:
-
personal care products
- EDCs:
-
endocrine-disrupting compounds
- ASWs:
-
artificial sweeteners
- WWTPs:
-
wastewater treatment plants
- DWTPs:
-
drinking water treatment plants
- RQ:
-
risk quotient
- HQ:
-
hazardous quotient
- MDL:
-
method detection limit
- PECs:
-
predicted environmental concentrations
- PNECs:
-
predicted no effect concentration
References
Jakeman AJ, Barreteau O, Hunt RJ, Rinaudo JD, Ross A (2016). Integrated groundwater management: concepts, approaches and challenges. Integr Groundw Manag Concepts, Approaches Challenges. Published online 1-762. https://doi.org/10.1007/978-3-319-23576-9
K. Fent, A.A. Weston, D. Caminada, Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 76(2), 122–159 (2006). https://doi.org/10.1016/j.aquatox.2005.09.009
National Groundwater Association. (2013) Facts about global groundwater usage. (2):7-8. http://www.ngwa.org/Fundamentals/use/Documents/global-groundwater-use-fact-sheet.pdf. accessed 28 Nov 2020
V. Geissen, H. Mol, E. Klumpp, et al., Emerging pollutants in the environment: a challenge for water resource management. Int Soil Water Conserv Res. 3(1), 57–65 (2015). https://doi.org/10.1016/j.iswcr.2015.03.002
David W. Clark and David W. Briar What is ground water? Open-File Report 93–643. https://doi.org/10.3133/ofr93643
M.J. Benotti, B.J. Brownawell, Microbial degradation of pharmaceuticals in estuarine and coastal seawater. Environ. Pollut. 157(3), 994–1002 (2009). https://doi.org/10.1016/j.envpol.2008.10.009
M. Giordano, Global groundwater? Issues and solutions. Annu. Rev. Environ. Resour. 34, 153–178 (2009). https://doi.org/10.1146/annurev.environ.030308.100251
M.B. Tahir, H. Kiran, T. Iqbal. The detoxification of heavy metals from aqueous environment using nano-photocatalysis approach: a review. Environmental Science and Pollution Research 26, 10515–10528 (2019)
A. Togola, H. Budzinski, Multi-residue analysis of pharmaceutical compounds in aqueous samples. J. Chromatogr. A 1177(1), 150–158 (2008). https://doi.org/10.1016/j.chroma.2007.10.105
Néstor M.C., Mariana C. Impact of Pharmaceutical Waste on Biodiversity. In: Gómez-Oliván L. (eds) Ecopharmacovigilance. The Handbook of Environmental Chemistry, vol 66. Springer, Cham (2017). https://doi.org/10.1007/698_2017_151
M. la Farré, S. Pérez, L. Kantiani, D. Barceló, Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment. TrAC - Trends Anal Chem. 27(11), 991–1007 (2008). https://doi.org/10.1016/j.trac.2008.09.010
A. Pal, K.Y.H. Gin, A.Y.C. Lin, M. Reinhard, Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Sci. Total Environ. 408(24), 6062–6069 (2010). https://doi.org/10.1016/j.scitotenv.2010.09.026
S.K. Sharma, R. Sanghi, Wastewater reuse and management. Wastewater Reuse Manag. Published online 1-500 (2013). https://doi.org/10.1007/978-94-007-4942-9
T. Yin, H. Chen, M. Reinhard, X. Yi, Y. He, K.Y. Gin, Perfluoroalkyl and polyfluoroalkyl substances removal in a fullscale tropical constructed wetland system treating landfill leachate. Water Res. 125, 418–426 (2017). https://doi.org/10.1016/j.watres.2017.08.071
B.A. Wilson, V.H. Smith, F. Denoyelles, C.K. Larive, Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages. Environ. Sci. Technol. 37(9), 1713–1719 (2003). https://doi.org/10.1021/es0259741
P. Rezka, W. Balcerzak, Z. Naukowe, et al., The occurrence of non-steroidal anti-inflammatory drugs in wastewater and water environment and methods of their removal – selected issues. Arch Waste Manag Environ Prot. 7(2), 6–11 (2013)
C.B. Patneedi, P.K. Durga, Impact of pharmaceutical wastes on human life and environment. Rasayan J. Chem. 8(1), 67–70 (2015)
J. Wu, J. Yue, R. Hu, Z. Yang, L. Zhang, Use of caffeine and human pharmaceutical compounds to identify sewage contamination. World Acad. Sci. Eng. Technol. 44, 438–442 (2008)
B. Halling-Sørensen, Algal toxicity of antibacterial agents used in intensive farming. Chemosphere. 40(7), 731–739 (2000). https://doi.org/10.1016/S0045-6535(99)00445-2
S.S.D. Foster, P.J. Chilton, Groundwater: the processes and global significance of aquifer degradation. Philos. Trans. R.Soc, B, Biol, Sci. 358(1440), 1957–1972 (2003). https://doi.org/10.1098/rstb.2003.1380
M. Xu, H. Huang, N. Li, F. Li, D. Wang, Q. Luo, Occurrence and ecological risk of pharmaceuticals and personal care products (PPCPs) and pesticides in typical surface watersheds, China. Ecotoxicol. Environ. Saf. 175(October 2018), 289–298 (2019). https://doi.org/10.1016/j.ecoenv.2019.01.131
D.G.J. Larsson, Antibiotics in the environment. Ups. J. Med. Sci. 119(2), 108–112 (2014). https://doi.org/10.3109/03009734.2014.896438
A. Hossaina, S. Nakamichia, M. Habibullah-Al-Mamuna, K. Tania, S. Masunagac, H. Matsuda, Environ. Res. 165, 258–266 (2018)
I. Hantoro, A.J. Löhr, F.G.A.J. Van Belleghem, B. Widianarko, A.M.J. Ragas, Microplastics in coastal areas and seafood: implications for food safety. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess. 36(5), 674–711 (2019). https://doi.org/10.1080/19440049.2019.1585581
Q. Zhang, P. Xu, H. Qian, Groundwater quality assessment using improved Water Quality Index (WQI) and Human Health Risk (HHR) evaluation in a semi-arid region of Northwest China. Expo Health. 12(3), 487–500 (2020). https://doi.org/10.1007/s12403-020-00345-w
C.S.H. Tan, K.D. Go, X. Bisteau, et al., Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells. Science (80-)359(6380), 1170–1177 (2018). https://doi.org/10.1126/science.aan0346
K. Kümmerer, The presence of pharmaceuticals in the environment due to human use - present knowledge and future challenges. J. Environ. Manag. 90(8), 2354–2366 (2009a). https://doi.org/10.1016/j.jenvman.2009.01.023
C. Ding, J. He. Effect of antibiotics in the environment on microbial populations. Appl Microbiol Biotechnol 87, 925–941 (2010). https://doi.org/10.1007/s00253-010-2649-5
X. Peng, Y. Yu, C. Tang, J. Tan, Q. Huang, Z. Wang, Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta. South China. Sci. Total. Environ. 397(1-3), 158–166 (2008). https://doi.org/10.1016/j.scitotenv.2008.02.059
P.K. Bishop, B.D. Misstear, M. White, N.J. Harding, Impacts of sewers on groundwater quality. Water. Environ. J. 12(3), 216–223 (1998). https://doi.org/10.1111/j.1747-6593.1998.tb00176.x
L. Minguez, J. Pedelucq, E. Farcy, C. Ballandonne, H. Budzinski, M.P. Halm-Lemeille, Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France. Environ. Sci. Pollut. Res. 23(6), 4992–5001 (2016). https://doi.org/10.1007/s11356-014-3662-5
L. Ahrens, H. Gashaw, M. Sjöholm, et al., Poly- and perfluoroalkylated substances (PFASs) in water, sediment and fish muscle tissue from Lake Tana, Ethiopia and implications for human exposure. Chemosphere. 165, 352–357 (2016a). https://doi.org/10.1016/j.chemosphere.2016.09.007
P.K. Jjemba, Excretion and ecotoxicity of pharmaceutical and personal care products in the environment. Ecotoxicol. Environ. Saf. 63(1), 113–130 (2006). https://doi.org/10.1016/j.ecoenv.2004.11.011
R. Akhbarizadeh, S. Dobaradaran, T.C. Schmidt, I. Nabipour, J. Spitz, Worldwide bottled water occurrence of emerging contaminants: a review of the recent scientific literature. J. Hazard. Mater. 392(February), 122271 (2020). https://doi.org/10.1016/j.jhazmat.2020.122271
H. Arfaeinia, I. Nabipour, A. Ostovar, et al., Assessment of sediment quality based on acid-volatile sulfide and simultaneously extracted metals in heavily industrialized area of Asaluyeh, Persian Gulf: concentrations, spatial distributions, and sediment bioavailability/toxicity. Environ. Sci. Pollut. Res. 23(10), 9871–9890 (2016). https://doi.org/10.1007/s11356-016-6189-0
J. Wilkinson, P.S. Hooda, J. Barker, S. Barton, J. Swinden, Occurrence, fate and transformation of emerging contaminants in water: an overarching review of the field. Environ. Pollut. 231, 954–970 (2017b). https://doi.org/10.1016/j.envpol.2017.08.032
J.O. Williams, S.P. White, Impact of disinfectants on antimicrobial potentials of some microorganisms impact of disinfectants on antimicrobial potentials of some microorganisms. J Pharm Biol Sci. 11(6), 104–107 (2016). https://doi.org/10.9790/3008-110606104107
S. Fattorini, B. Fiasca, T. Di Lorenzo, M. Di Cicco, D.M.P. Galassi, A new protocol for assessing the conservation priority of groundwater-dependent ecosystems. Aquat. Conserv. Mar. Freshwat. Ecosyst. 30(8), 1483–1504 (2020). https://doi.org/10.1002/aqc.3411
R. Akhbarizadeh, F. Moore, B. Keshavarzi, Investigating microplastics bioaccumulation and biomagnification in seafood from the Persian Gulf: a threat to human health? Food Addit Contam - Part A Chem Anal Control Expo Risk Assess. 36(11), 1696–1708 (2019). https://doi.org/10.1080/19440049.2019.1649473
A. Gogoi, P. Mazumder, V.K. Tyagi, G.G. Tushara Chaminda, A.K. An, M. Kumar, Occurrence and fate of emerging contaminants in water environment: a review. Groundw. Sustain. Dev. 6(December 2017), 169–180 (2018). https://doi.org/10.1016/j.gsd.2017.12.009
M.C.V.M. Starling, C.C. Amorim, M.M.D. Leão, Occurrence, control and fate of contaminants of emerging concern in environmental compartments in Brazil. J. Hazard. Mater.. Published online 372, 17–36 (2019). https://doi.org/10.1016/j.jhazmat.2018.04.043
K.L. Del Rosario, S. Mitra, C.P. Humphrey, M.A. O’Driscoll, Detection of pharmaceuticals and other personal care products in groundwater beneath and adjacent to onsite wastewater treatment systems in a coastal plain shallow aquifer. Sci. Total Environ. 487, 216–223 (2014)
P. Bottoni, S. Caroli, A.B. Caracciolo, Pharmaceuticals as priority water contaminants. Toxicol. Environ. Chem. 92(3), 549–565 (2010). https://doi.org/10.1080/02772241003614320
K.A. Ahrens, B.A. Haley, L.M. Rossen, P.C. Lloyd, Y. Aoki, Housing assistance and blood lead levels: children in the United States, 2005-2012. Am. J. Public Health 106(11), 2049–2056 (2016b). https://doi.org/10.2105/AJPH.2016.303432
B. Soulet, A. Tauxe, J. Tarradellas, Analysis of acidic drugs in Swiss wastewaters. Int. J. Environ. Anal. Chem. 82(10), 659–667 (2002). https://doi.org/10.1080/0306731021000075384
O.A.H. Jones, N. Voulvoulis, J.N. Lester, Human pharmaceuticals in wastewater treatment processes. Crit. Rev. Environ. Sci. Technol. 35(4), 401–427 (2005). https://doi.org/10.1080/10643380590956966
W. Petersen, 2016 exploring the occurrence and distribution of contaminants of emerging concern through unmanned sampling from ships of opportunity in the North Sea. J Mar Syst 162, 47–56 (2016). https://doi.org/10.1016/j.jmarsys.2016.03.004
I.Y. López-Pacheco, A. Silva-Núñez, C. Salinas-Salazar, et al., Anthropogenic contaminants of high concern: existence in water resources and their adverse effects. Sci. Total Environ. 690, 1068–1088 (2019a). https://doi.org/10.1016/j.scitotenv.2019.07.052
J.O. Tijani, O.O. Fatoba, O.O. Babajide, L.F. Petrik, Pharmaceuticals, endocrine disruptors, personal care products, nanomaterials and perfluorinated pollutants: a review. Environ. Chem. Lett. 14(1), 27–49 (2016). https://doi.org/10.1007/s10311-015-0537-z
J.E. Drewes, P. Fox, M. Jekel, Occurrence of iodinated X-ray contrast media in domestic effluents and their fate during indirect potable reuse. J Environ Sci Heal - Part A Toxic/Hazardous Subst Environ Eng. 36(9), 1633–1645 (2001). https://doi.org/10.1081/ESE-100106248
M. Ahmadi, R. Akhbarizadeh, N.J. Haghighifard, G. Barzegar, S. Jorfi, Geochemical determination and pollution assessment of heavy metals in agricultural soils of south western of Iran 05 Environmental Sciences 0503 Soil Sciences. J. Environ. Health Sci. Eng. 17(2), 657–669 (2019). https://doi.org/10.1007/s40201-019-00379-6
K.O. K’oreje, M. Okoth, H. Van Langenhove, K. Demeestere, Occurrence and treatment of contaminants of emerging concern in the African aquatic environment: literature review and a look ahead. J. Environ. Manag. 254(February 2019), 109752 (2020). https://doi.org/10.1016/j.jenvman.2019.109752
E. Archer, B. Petrie, B. Kasprzyk-Hordern, G.M. Wolfaardt, The fate of pharmaceuticals and personal care products (PPCPs), endocrine disrupting contaminants (EDCs), metabolites and illicit drugs in a WWTW and environmental waters. Chemosphere. 174, 437–446 (2017). https://doi.org/10.1016/j.chemosphere.2017.01.101
A. Helenkár, Á. Sebk, G. Záray, I. Molnár-Perl, A. Vasanits-Zsigrai, The role of the acquisition methods in the analysis of the non-steroidal anti-inflammatory drugs in Danube River by gas chromatography-mass spectrometry. Talanta. 82(2), 600–607 (2010). https://doi.org/10.1016/j.talanta.2010.05.014
J. Li, Y. Wang, X. Xie, C. Su, Hierarchical cluster analysis of arsenic and fluoride enrichments in groundwater from the Datong Basin, Northern China. J. Geochem. Explor. 118, 77–89 (2012). https://doi.org/10.1016/j.gexplo.2012.05.002
A. Nikolaou, S. Meric, D. Fatta, Occurrence patterns of pharmaceuticals in water and wastewater environments. Anal. Bioanal. Chem. 387(4), 1225–1234 (2007). https://doi.org/10.1007/s00216-006-1035-8
J. Li, Y. Wang, X. Xie, C. Su, Hierarchical cluster analysis of arsenic and fluoride enrichments in groundwater from the Datong Basin, Northern China. J. Geochem. Explor. 118, 77–89 (2012). https://doi.org/10.1016/j.gexplo.2012.05.002
S. Dobaradaran, T.C. Schmidt, I. Nabipour, et al., Cigarette butts abundance and association of mercury and lead along the Persian Gulf beach: an initial investigation. Environ. Sci. Pollut. Res. 25(6), 5465–5473 (2018b). https://doi.org/10.1007/s11356-017-0676-9
D. Ghernaout, N. Elboughdiri, Water reuse: emerging contaminants elimination—progress and trends. OALib. 06(12), 1–9 (2019a). https://doi.org/10.4236/oalib.1105981
M. Boy-Roura, B.T. Nolan, A. Menico, J. Mas-Pla, Regression model for aquifer vulnerability assessment of nitrate pollution in the Osona region (NE Spain). J. Hydrol. 505, 150–162 (2013)
A.L. Baker, J.M. Warner, Burkholderia pseudomallei is frequently detected in groundwater that discharges to major watercourses in northern Australia. Folia Microbiol. 61, 301–305 (2016). https://doi.org/10.1007/s12223-015-0438-3
H. Bouwman, C. Bezuidenhout, S. Horn, T. Vogt, L. Bothma, E. Gerber, D. van Aswegen, K. Blom, D. Fouché, J. Potgieter, M. Spies, L. van der Merwe, R. Muller, R. Pieters, M. Muller, S. Cilliers, F. Wafawanaka, T. Erasmus, P. Bester, et al., Quantification, fate and hazard assessment of hiv-arvs in water resources. Report to the Water Research Commission 2, 1–124 (2020)
T. Di Lorenzo, G.C. Hose, D.M.P. Galassi, Assessment of different contaminants in freshwater: origin, fate and ecological impact. Water 12(6), 1810 (2020). https://doi.org/10.3390/w12061810
S. Corsolini, G. Sarà, The trophic transfer of persistent pollutants (HCB, DDTs, PCBs) within polar marine food webs. Chemosphere. 177, 189–199 (2017). https://doi.org/10.1016/j.chemosphere.2017.02.116
A.J. Ebele, M. Abou-Elwafa Abdallah, S. Harrad, Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment. Emerg. Contam. 3(1), 1–16 (2017). https://doi.org/10.1016/j.emcon.2016.12.004
K.O. K’oreje, L. Vergeynst, D. Ombaka, et al., Occurrence patterns of pharmaceutical residues in wastewater, surface water and groundwater of Nairobi and Kisumu City. Kenya. Chemosphere. 149, 238–244 (2016). https://doi.org/10.1016/j.chemosphere.2016.01.095
Ahmad AA et al. (2017) Book. 2019;(December 2017).
M. Abtahi, A. Mohseni-Bandpei, A. Koolivand, et al., Defluoridation of synthetic and natural waters by polyaluminum chloride-chitosan(PACl-Ch) composite coagulant. Water Sci. Technol. Water Supply 18(1), 259–269 (2018). https://doi.org/10.2166/ws.2017.085
Z. Visanji, S.M.K. Sadr, M.B. Johns, D. Savic, F.A. Memon, Optimising wastewater treatment solutions for the removal of contaminants of emerging concern: a case study for application in India. J. Hydroinf. 22(1), 93–110 (2020). https://doi.org/10.2166/hydro.2019.031
K. Balakrishna, A. Rath, Y. Praveenkumarreddy, K.S. Guruge, B. Subedi, A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies. Ecotoxicol. Environ. Saf. 137, 113–120 (2017). https://doi.org/10.1016/j.ecoenv.2016.11.014
S. Dobaradaran, T.C. Schmidt, N. Lorenzo-Parodi, et al., Polycyclic aromatic hydrocarbons (PAHs) leachates from cigarette butts into water. Environ. Pollut. 259, 113916 (2020b). https://doi.org/10.1016/j.envpol.2020.113916
U. Eriksson, A. Kärrman, A. Rotander, B. Mikkelsen, M. Dam, Perfluoroalkyl substances (PFASs) in food and water from Faroe Islands. Environ. Sci. Pollut. Res. 20(11), 7940–7948 (2013). https://doi.org/10.1007/s11356-013-1700-3
X. Yang, R.C. Flowers, H.S. Weinberg, P.C. Singer, Occurrence and removal of pharmaceuticals and personal care products (PPCPs) in an advanced wastewater reclamation plant. Water Res. 45(16), 5218–5228 (2011). https://doi.org/10.1016/j.watres.2011.07.026
W.C. Li, Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environ. Pollut. 187, 193–201 (2014). https://doi.org/10.1016/j.envpol.2014.01.015
P. Verlicchi, A. Galletti, M. Petrovic, D. Barceló, M. Al Aukidy, E. Zambello, Removal of selected pharmaceuticals from domestic wastewater in an activated sludge system followed by a horizontal subsurface flow bed — analysis of their respective contributions. Sci Total Environ., ISSN: 0048-9697 454, 411–425 (2013). https://doi.org/10.1016/j.scitotenv.2013.03.044
M. Lei, L. Zhang, J. Lei, et al., Overview of emerging contaminants and associated human health effects. Biomed. Res. Int. 2015, 404796 (2015). https://doi.org/10.1155/2015/404796
G. Lofrano, G. Libralato, S. Meric, et al., Occurrence and potential risks of emerging contaminants in water. Elsevier Inc. (2020). https://doi.org/10.1016/b978-0-12-818334-2.00001-8
S. Weigel, U. Berger, E. Jensen, R. Kallenborn, H. Thoresen, H. Hühnerfuss, Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with emphasis on ibuprofen and its metabolites. Chemosphere. 56(6), 583–592 (2004). https://doi.org/10.1016/j.chemosphere.2004.04.015
J.L. Wilkinson, P.S. Hooda, J. Swinden, J. Barker, S. Barton, Spatial distribution of organic contaminants in three rivers of Southern England bound to suspended particulate material and dissolved in water. Sci. Total Environ 593-594, 487–497 (2017a). https://doi.org/10.1016/j.scitotenv.2017.03.167
N.H. Tran, J. Li, J. Hu, S.L. Ong, Occurrence and suitability of pharmaceuticals and personal care products as molecular markers for raw wastewater contamination in surface water and groundwater. Environ. Sci. Pollut. Res. 21(6), 4727–4740 (2014). https://doi.org/10.1007/s11356-013-2428-9
J.K. Sial, S. Mahmood, Groundwater contamination from agro-chemicals in irrigated environment: field trials. Groundw Updat. 3(5), 129–134 (2000). https://doi.org/10.1007/978-4-431-68442-8_22
R. Rahman, A.J. Plater, P.J. Nolan, B. Mauz, P.G. Appleby, Potential health risks from radioactive contamination of saltmarshes in NW England. J. Environ. Radioact. 119, 55–62 (2013). https://doi.org/10.1016/j.jenvrad.2011.11.011
B.L.L. Tan, D.W. Hawker, J.F. Müller, F.D.L. Leusch, L.A. Tremblay, H.F. Chapman, Modelling of the fate of selected endocrine disruptors in a municipal wastewater treatment plant in South East Queensland, Australia. Chemosphere. 69(4), 644–654 (2007). https://doi.org/10.1016/j.chemosphere.2007.02.057
N. Lindqvist, T. Tuhkanen, L. Kronberg, Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters. Water Res. 39(11), 2219–2228 (2005). https://doi.org/10.1016/j.watres.2005.04.003
J. Lienert, M. Koller, J. Konrad, C.S. McArdell, N. Schuwirth, Multiple-criteria decision analysis reveals high stakeholder preference to remove pharmaceuticals from hospital wastewater. Environ. Sci. Technol. 45(9), 3848–3857 (2011). https://doi.org/10.1021/es1031294
M. Kajta, J. Rzemieniec, E. Litwa, et al., The key involvement of estrogen receptor β and G-protein-coupled receptor 30 in the neuroprotective action of daidzein. Neuroscience. 238, 345–360 (2013). https://doi.org/10.1016/j.neuroscience.2013.02.005
D.B. Huggett, J.C. Cook, J.F. Ericson, R.T. Williams, A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish. Hum. Ecol. Risk. Assess. 9(7), 1789–1799 (2003). https://doi.org/10.1080/714044797
I.B. Gomes, L.C. Simões, M. Simões, The effects of emerging environmental contaminants on Stenotrophomonas maltophilia isolated from drinking water in planktonic and sessile states. Sci. Total Environ. 643, 1348–1356 (2018). https://doi.org/10.1016/j.scitotenv.2018.06.263
D. Fatta-Kassinos, S. Meric, A. Nikolaou, Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research. Anal. Bioanal. Chem. 399(1), 251–275 (2011). https://doi.org/10.1007/s00216-010-4300-9
S.S.D. Foster, P.J. Chilton, Downstream of downtown: urban wastewater as groundwater recharge. Hydrogeol. J. 12(1), 115–120 (2004). https://doi.org/10.1007/s10040-003-0296-y
S. Bartelt-Hunt, D.D. Snow, P.T. Damon, D. Miesbach, Occurrence of steroid hormones and antibiotics in shallow groundwater impacted by livestock waste control facilities. J. Contam. Hydrol. 123(3–4), 94–103 (2011)
A.J. Barbera, V.D. McConnell, The impact of environmental regulations on industry productivity: direct and indirect effects. J. Environ. Econ. Manag. 18(1), 50–65 (1990). https://doi.org/10.1016/0095-0696(90)90051-Y
E. Mohle, S. Horvath, W. Merz, J.W. Metzger, Determination of hardly degradable organic compounds in wastewater—identification of drugs. Vom Wasser 92, 207–223
H. Bártíková, L. Skálová, L. Stuchlíková, I. Vokřál, T. Vaněk, R. Podlipná, Xenobiotic-metabolizing enzymes in plants and their role in uptake and biotransformation of veterinary drugs in the environment. Drug Metab. Rev. 47(3), 374–387 (2015 Aug). https://doi.org/10.3109/03602532.2015.1076437
Y. Luo, W. Guo, H.H. Ngo, L.D. Nghiem, F.I. Hai, J.J. Zhang, S. Liang, X.C. Wang, A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment. Sci. Total Environ. 473, 619–641 (2013). ISSN: 0048-9697, https://doi.org/10.1016/j.scitotenv.2013.12.065
S. Esplugas, D.M. Bila, L. Gustavo, T. Krausec, M. Dezottic, Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. J Hazard Mater. 149(3), 631–642 (2007)
J. Rivera-Utrilla, M. Sánchez-Polo, M.Á. Ferro-García, G. Prados-Joya, R. Ocampo-Pérez, Pharmaceuticals as emerging contaminants and their removal from water. A review. Chemosphere 93(7), 1268–1287 (2013). https://doi.org/10.1016/j.chemosphere.2013.07.059
C. Sonnenschein, A.M. Soto, An updated review of environmental estrogen and androgen mimics and antagonists. J. Steroid Biochem. Mol. Biol. 65(1-6), 143–150 (1998). https://doi.org/10.1016/S0960-0760(98)00027-2
C. Ding, J. He, Effect of antibiotics in the environment on microbial populations. Appl. Microbiol. Biotechnol. 87(3), 925–941 (2010). https://doi.org/10.1007/s00253-010-2649-5
S. Sauvé, M. Desrosiers, A review of what is an emerging contaminant. Chemistry Central Journal 8, 15 (2014). https://doi.org/10.1186/1752-153X-8-15
L. Yang, J.-T. He, S.-H. Su, Y.-F. Cui, D.-L. Huang, G.-C. Wang, Occurrence, distribution, and attenuation of pharmaceuticals and personal care products in the riverside groundwater of the Beiyun River of Beijing, China. Environ. Sci. Pollut. Res. 24(18), 15838–15851 (2017)
M.A.M. Mahmoud, A. Kärrman, S. Oono, K.H. Harada, A. Koizumi, Polyfluorinated telomers in precipitation and surface water in an urban area of Japan. Chemosphere. 74(3), 467–472 (2009). https://doi.org/10.1016/j.chemosphere.2008.08.029
L. Jiang, X. Hu, T. Xu, H. Zhang, D. Sheng, D. Yin, Prevalence of antibiotic resistance genes and their relationship with antibiotics in the Huangpu River and the drinking water sources, Shanghai, China. Sci. Total Environ. 458-460, 267–272 (2013). https://doi.org/10.1016/j.scitotenv.2013.04.038
L.M. Boström, B. Olof, Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges. Water Res., ISSN: 0043-1354 72, 154–161 (2014). https://doi.org/10.1016/j.watres.2014.08.040
F. Pomati, A.G. Netting, D. Calamari, B.A. Nelian, Effects of erythromycin, tetracycline and ibuprofen on the growth of Synechocystis sp. and Lemna minor. Aquat. Toxicol. 67(4), 387–396 (2004). https://doi.org/10.1016/j.aquatox.2004.02.001
K. Kümmerer, Antibiotics in the aquatic environment - a review - Part I. Chemosphere. 75(4), 417–434 (2009b). https://doi.org/10.1016/j.chemosphere.2008.11.086
R.A. Mathew, S. Kanmani, A review on emerging contaminants in Indian waters and their treatment technologies. Nat. Environ. Pollut. Technol. 19(2), 549–562 (2020). https://doi.org/10.46488/NEPT.2020.V19I02.010
J.L. Martinez, Environmental pollution by antibiotics and by antibiotic resistance determinants. Environ. Pollut. 157(11), 2893–2902 (2009). https://doi.org/10.1016/j.envpol.2009.05.051
V. Homem, L. Santos, Degradation and removal methods of antibiotics from aqueous matrices - a review. J. Environ. Manag. 92(10), 2304–2347 (2011). https://doi.org/10.1016/j.jenvman.2011.05.023
X.S. Miao, B.G. Koenig, C.D. Metcalfe, Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. A 952(1-2), 139–147 (2002). https://doi.org/10.1016/S0021-9673(02)00088-2
N.J. Velez-Ruiz, K.J. Meador, Neurodevelopmental effects of fetal antiepileptic drug exposure. Drug Saf. 38(3), 271–278 (2015). https://doi.org/10.1007/s40264-015-0269-9
S. Kim, D.S. Aga, Potential ecological and human health impacts of antibiotics and antibiotic-resistant bacteria from wastewater treatment plants. J Toxicol Environ Heal - Part B Crit Rev. 10(8), 559–573 (2007). https://doi.org/10.1080/15287390600975137
P. Kovalakova, L. Cizmas, T.J. McDonald, B. Marsalek, M. Feng, V.K. Sharma, Occurrence and toxicity of antibiotics in the aquatic environment: a review. Chemosphere. 251, 126351 (2020). https://doi.org/10.1016/j.chemosphere.2020.126351
R. López-Serna, A. Jurado, E. Vázquez-Suñé, J. Carrera, M. Petrović, D. Barceló, Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain. Environ Pollut. 174, 305–315 (2013). https://doi.org/10.1016/j.envpol.2012.11.022
G. Prasannamedha, P.S. Kumar, A review on contamination and removal of sulfamethoxazole from aqueous solution using cleaner techniques: Present and future perspective. J. Clean. Prod. 250, 119553 (2020). https://doi.org/10.1016/j.jclepro.2019.119553
D. Chapman, Groundwater pollution - developments in water science. Water Qual Assessments - A Guid to Use Biota, Sediments Water Environ Monit - Second Ed Ed 5(21), 273 (1996) http://www.who.int/water_sanitation_health/resourcesquality/wqachapter9.pdf. accessed 17 October 2020
M. Stuart, D. Lapworth, Smart Sensors for Real-Time Water Quality Monitoring. 4, 259–284 (2013). https://doi.org/10.1007/978-3-642-37006-9
N. Nakada, K. Kiri, H. Shinohara, et al., Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage. Environ. Sci. Technol. 42(17), 6347–6353 (2008). https://doi.org/10.1021/es7030856
Bonavigo M. De Salve, M. Zucchetti, D. Annunziata, Radioactivity release and dust production during the cutting of the primary circuit of a nuclear power plant: the case of E. Fermi NPP, Prog. Nucl. Energy. 52(4), 59–366 (2010). https://doi.org/10.1016/j.pnucene.2009.07.009
F. Baquero, J.L. Martínez, R. Cantón, Antibiotics and antibiotic resistance in water environments. Curr. Opin. Biotechnol. 19(3), 260–265 (2008). https://doi.org/10.1016/j.copbio.2008.05.006
S. Dobaradaran, T.C. Schmidt, I. Nabipour, et al., Characterization of plastic debris and association of metals with microplastics in coastline sediment along the Persian Gulf. Waste Manag. 78, 649–658 (2018a). https://doi.org/10.1016/j.wasman.2018.06.037
J.L. Liu, M.H. Wong, Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. Environ. Int. 59, 208–224 (2013). https://doi.org/10.1016/j.envint.2013.06.012
N.S. Rao, Nitrate pollution and its distribution in the groundwater of Srikakulam district, Andhra Pradesh. India. Environ Geol. 51(4), 631–645 (2006). https://doi.org/10.1007/s00254-006-0358-2
G.E. Cordy, N.L. Duran, H. Bouwer, R.C. Rice, E.T. Furlong, S.D. Zaugg, M.T. Meyer, L.B. Barber, D.W. Kolpin, Do pharmaceuticals, pathogens, and other organic waste water compounds persist when waste water is used for recharge? 24(2), 58–69 (2004). https://doi.org/10.1111/j.1745-592.2004.tb00713.x
M. Silvia Díaz-Cruz, D. Barceló, Trace organic chemicals contamination in groundwater recharge. 72(3), 0–342 (2008). https://doi.org/10.1016/j.chemosphere.2008.02.031
G. Massmann, J. Greskowiak, U. Dünnbier, S. Zuehlke, A. Knappe, A. Pekdeger, The impact of variable temperatures on the redox conditions and the behavior of pharmaceutical residues during artificial recharge. 328(1–2), 0–156 (2006). https://doi.org/10.1016/j.jhydrol.2005.12.009
B. Kasprzyk-Hordern, R.M. Dinsdale, A.J. Guwy, The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res. 42(13), 3498–3518 (2008). https://doi.org/10.1016/j.watres.2008.04.026
J.K. Böhlke, Groundwater recharge and agricultural contamination. Hydrogeol. J. 10(1), 153–179 (2002). https://doi.org/10.1007/s10040-001-0183-3
J.L. Shuster, A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic clonic seizures in adults. Psychosomatics. 34(5), 464 (1993). https://doi.org/10.1056/nejm199209103271104
K.V. Thomas, M.J. Hilton, The occurrence of selected human pharmaceutical compounds in UK estuaries. Mar. Pollut. Bull. 49(5-6), 436–444 (2004). https://doi.org/10.1016/j.marpolbul.2004.02.028
S.H. Campbell, P.R. Williamson, B.D. Hall, Microplastics in the gastrointestinal tracts of fish and the water from an urban prairie creek. FACETS 2, 395–409 (2017). https://doi.org/10.1139/facets-2017-0008
D.N.R. de Sousa, S. Insa, A.A. Mozeto, M. Petrovic, T.F. Chaves, P.S. Fadini, Equilibrium and kinetic studies of the adsorption of antibiotics from aqueous solutions onto powdered zeolites. Chemosphere. 205, 137–146 (2018). https://doi.org/10.1016/j.chemosphere.2018.04.085
T.A. Ternes, Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32(11), 3245–3260 (1998). https://doi.org/10.1016/S0043-1354(98)00099-2
A.B.A. Boxall, M.A. Rudd, B.W. Brooks, D.J. Caldwell, K. Choi, S. Hickmann, E. Innes, K. Ostapyk, J.P. Staveley, T. Verslycke, G.T. Ankley, K.F. Beazley, S.E. Belanger, J.P. Berninger, P. Carriquiriborde, A. Coors, P.C. DeLeo, S.D. Dyer, J.F. Ericson, et al., Pharmaceuticals and personal care products in the environment: what are the big questions? Environ. Health Perspect. 120(9), 1221–1229 (2012). https://doi.org/10.1289/ehp.1104477
B.F. da Silva, A. Jelic, R. López-Serna, A.A. Mozeto, M. Petrovic, D. Barceló, Occurrence and distribution of pharmaceuticals in surface water, suspended solids and sediments of the Ebro river basin, Spain. Chemosphere. 85(8), 1331–1339 (2011). https://doi.org/10.1016/j.chemosphere.2011.07.051
T. Rasheed, M. Bilal, F. Nabeel, M. Adeel, H.M.N. Iqbal, Environmentally-related contaminants of high concern: potential sources and analytical modalities for detection, quantification, and treatment. Environ. Int. 122(November 2018), 52–66 (2019). https://doi.org/10.1016/j.envint.2018.11.038
Y. Chen, G. Yu, Q. Cao, H. Zhang, Q. Lin, Y. Hong, Occurrence and environmental implications of pharmaceuticals in Chinese municipal sewage sludge. Chemosphere. 93(9), 1765–1772 (2013). https://doi.org/10.1016/j.chemosphere.2013.06.007
J. Sanchís, L. Kantiani, M. Llorca, et al., Determination of glyphosate in groundwater samples using an ultrasensitive immunoassay and confirmation by on-line solid-phase extraction followed by liquid chromatography coupled to tandem mass spectrometry. Anal. Bioanal. Chem. 402(7), 2335–2345 (2012). https://doi.org/10.1007/s00216-011-5541-y
M.S. Fram, K. Belitz, Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in California. 409(18), 3409–3417 (2011). https://doi.org/10.1016/j.scitotenv.2011.05.053
E. Godfrey, W.W. Woessner, M.J. Benotti, Pharmaceuticals in on-site sewage effluent and ground water, Western Montana. 45(3), 263–271 (2007). https://doi.org/10.1111/j.1745-6584.2006.00288.x
P. Paíga, L.H.M.L.M. Santos, S. Ramos, S. Jorge, J.G. Silva, C. Delerue-Matos, Presence of pharmaceuticals in the Lis river (Portugal): sources, fate and seasonal variation. Sci. Total Environ. 573, 164–177 (2016). https://doi.org/10.1016/j.scitotenv.2016.08.0
S. Kar, K. Roy, Risk assessment for ecotoxicity of pharmaceuticals an emerging issue. Expert Opin. Drug Saf. 11(2), 235–274 (2012). https://doi.org/10.1517/14740338.2012.644272
E. Vulliet, C. Cren-Olivé, Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption. Environ. Pollut. 159(10), 2929–2934 (2011). https://doi.org/10.1016/j.envpol.2011.04.033
Y.C. Lin, W.W.P. Lai, T.H. Hsin, L. AYC, Occurrence of pharmaceuticals, hormones, and perfluorinated compounds in groundwater in Taiwan. Environ. Monit. Assess. 187(5), 256 (2015). https://doi.org/10.1007/s10661-015-4497-3
P.E. Stackelberg, E.T. Furlong, M.T. Meyer, S.D. Zaugg, A.K. Henderson, D.B. Reissman, Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-water-treatment plant. Sci. Total Environ. 329(1-3), 99–113 (2004). https://doi.org/10.1016/j.scitotenv.2004.03.015
P. Paíga, C. Delerue-Matos, Determination of pharmaceuticals in groundwater collected in five cemeteries’ areas (Portugal). Sci. Total Environ. 569-570, 16–22 (2016). https://doi.org/10.1016/j.scitotenv.2016.06.090
S. Banzhaf, K. Nödler, T. Licha, A. Krein, T. Scheytt, Redox-sensitivity and mobility of selected pharmaceutical compounds in a low flow column experiment. Sci. Total Environ. 438, 113–121 (2012)
A.C. Collier, Pharmaceutical contaminants in potable water: potential concerns for pregnant women and children. Ecohealth. 4(2), 164–171 (2007). https://doi.org/10.1007/s10393-007-0105-5
R.J. Phillips, E.J. Kieffer, T.L. Powley, Loss of glia and neurons in the myenteric plexus of the aged Fischer 344 rat. Anat. Embryol (Berl)209(1), 19–30 (2004). https://doi.org/10.1007/s00429-004-0426-x
A. Kumar, I. Xagoraraki, Human health risk assessment of pharmaceuticals in water: an uncertainty analysis for meprobamate, carbamazepine, and phenytoin. Regul. Toxicol. Pharmacol. 57(2-3), 146–156 (2010). https://doi.org/10.1016/j.yrtph.2010.02.002
M. Kumar, S. Jaiswal, K.K. Sodhi, et al., Antibiotics bioremediation: perspectives on its ecotoxicity and resistance. Environ. Int. 124(October 2018), 448–461 (2019). https://doi.org/10.1016/j.envint.2018.12.065
EFSA Panel on Contaminants in the Food Chain (CONTAM), Presence of microplastics and nanoplastics in food, with particular focus on seafood. EFSA J. 14(6), e04501 (2016). https://doi.org/10.2903/j.efsa.2016.4501
I.Y. López-Pacheco, C. Salinas-Salazar, A. Silva-Núñez, et al., Removal and biotransformation of 4-nonylphenol by Arthrospira maxima and Chlorella vulgaris consortium. Environ. Res. 179, 108848 (2019b). https://doi.org/10.1016/j.envres.2019.108848
L.J. Carter, M. Williams, C. Böttcher, R.S. Kookana, Uptake of pharmaceuticals influences plant development and affects nutrient and hormone homeostases. Environ. Sci. Technol. 49(20), 12509–12518 (2015). https://doi.org/10.1021/acs.est.5b03468
L. Migliore, G. Brambilla, P. Casoria, C. Civitareale, S. Cozzolino, L. Gaudio, Effects of sulphadimethoxine contamination on barley (Hordeum distichum L., Poaceae, Liliopsida). Agric. Ecosyst. Environ. 60, 121–128 (1996)
S.M. Zainab, M. Junaid, N. Xu, R.N. Malik, Antibiotics and antibiotic resistant genes (ARGs) in groundwater: a global review on dissemination, sources, interactions, environmental and human health risks. Water Res. 187, 116455 (2020). https://doi.org/10.1016/j.watres.2020.116455
F.J. Peng, C.G. Pan, M. Zhang, et al., Occurrence and ecological risk assessment of emerging organic chemicals in urban rivers: Guangzhou as a case study in China. Sci. Total Environ. 589, 46–55 (2017). https://doi.org/10.1016/j.scitotenv.2017.02.200
M.H. Wu, C.J. Que, G. Xu, et al., Occurrence, fate and interrelation of selected antibiotics in sewage treatment plants and their receiving surface water. Ecotoxicol. Environ. Saf. 132, 132–139 (2016). https://doi.org/10.1016/j.ecoenv.2016.06.006
D. Azanu, C. Mortey, G. Darko, J.J. Weisser, B. Styrishave, R.C. Abaidoo, Uptake of antibiotics from irrigation water by plants. Chemosphere. 157, 107–114 (2016). https://doi.org/10.1016/j.chemosphere.2016.05.035
M.P. Sarva, Z.M.R. Maizatul, A.M.R. Fauzan, Y.W. Sze, Z.A. Ahmad, Occurrence and potential human health risk of pharmaceutical residues in drinking water from Putrajaya (Malaysia). Ecotoxicology and Environment Saftey 180, 549–556 (2019)
D. Ghernaout, N. Elboughdiri, Water reuse: emerging contaminants elimination—progress and trends. OALib. 06(12), 1–9 (2019b). https://doi.org/10.4236/oalib.1105981
F.A. Kibuye, H.E. Gall, K.R. Elkin, et al., Fate of pharmaceuticals in a spray-irrigation system: from wastewater to groundwater. Sci. Total Environ. 654, 197–208 (2019). https://doi.org/10.1016/j.scitotenv.2018.10.442
M.B. Leite, R.O. Xavier, P.T.S. Oliveira, F.K.G. Silva, D.M. Silva Matos, Groundwater depth as a constraint on the woody cover in a Neotropical Savanna. Plant Soil. 426(1-2), 1–15 (2018). https://doi.org/10.1007/s11104-018-3599-4
P.K. Mutiyar, A.K. Mittal, A. Pekdeger, Identification and monitoring of pesticides in a well field in Delhi, India. Chemical, Biological and Environmental Engineering. 188–191 (2009). https://doi.org/10.1142/9789814295048_0039
V. Roos, L. Gunnarsson, J. Fick, D.G.J. Larsson, C. Ruden, Prioritising pharmaceuticals for environmental risk assessment: towards adequate and feasible first-tier selection. Sci. Total Environ. 421-422, 102–110 (2012)
J.L. Oaks, M. Gilbert, M.Z. Virani, R.T. Watson, C.U. Meteyer, B.A. Rideout, et al., Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427(6975), 630–633 (2004)
P. Burkhardt-Holm, A. Peter, H. Segner, Decline of fish catch in Switzerland. Aquat. Sci. 64(1), 36–54 (2002)
L.J. Schulman, E.V. Sargent, B.D. Naumann, E.C. Faria, D.G. Dolan, J.P. Wargo, A human health risk assessment of pharmaceuticals in the aquatic environment. Human and Ecological Risk Assessment: An International Journal 8(4), 657–680 (2002). https://doi.org/10.1080/20028091057141
Q. Bu, B. Wang, J. Huang, S. Deng, G. Yu, Pharmaceuticals and personal care products in the aquatic environment in China: a review. J. Hazard. Mater. 262, 189–211 (2013). https://doi.org/10.1016/j.jhazmat.2013.08.040
L.F.V. Francisco, B. do Amaral Crispim, J.C.V. Spósito, et al., Metals and emerging contaminants in groundwater and human health risk assessment. Environ. Sci. Pollut. Res. 26(24), 24581–24594 (2019). https://doi.org/10.1007/s11356-019-05662-5
X.I.N. Ie, X.I.W. Ang, J.U.C. Hen, V.L.Z. Itko, T.A.N. Aichen, Response of the freshwater alga Chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin - Nie - 2009. Enviro. Toxicol Chem. Wiley OnlineLibrary 27(1), 168–173 (2008)
V.L. Cunningham, S.P. Binks, M.J. Olson, Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment. Regul. Toxicol. Pharmacol. 53(1), 39–45 (2009). https://doi.org/10.1016/j.yrtph.2008.10.006
C.M. de Jongh, P.J.F. Kooij, P. de Voogt, T.L. ter Laak, Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water. Sci. Total. Environ. 427-428, 70–77 (2012). https://doi.org/10.1016/j.scitotenv.2012.04.010
J.P.R. Sorensen, D.J. Lapworth, D.C.W. Nkhuwa, et al., Emerging contaminants in urban groundwater sources in Africa. Water Res. 72, 51–63 (2015). https://doi.org/10.1016/j.watres.2014.08.002
T. Di Lorenzo, M. Di Cicco, D. Di Censo, et al., Environmental risk assessment of propranolol in the groundwater bodies of Europe. Environ. Pollut. 255, 113189 (2019). https://doi.org/10.1016/j.envpol.2019.113189
N.H. Tran, M. Reinhard, E. Khan, et al., Emerging contaminants in wastewater, stormwater runoff, and surface water: application as chemical markers for diffuse sources. Sci. Total Environ. 676, 252–267 (2019). https://doi.org/10.1016/j.scitotenv.2019.04.160
T. Aus der Beek, F.A. Weber, A. Bergmann, et al., Pharmaceuticals in the environment-global occurrences and perspectives. Environ. Toxicol. Chem. 35(4), 823–835 (2016). https://doi.org/10.1002/etc.3339
J.O. Straub, Aquatic environmental risk assessment for human use of the old antibiotic sulfamethoxazole in Europe. Environ. Toxicol. Chem. 35(4), 767–779 (2016). https://doi.org/10.1002/etc.2945
Q. Sui, X. Cao, S. Lu, W. Zhao, Z. Qiu, G. Yu, Occurrence, sources and fate of pharmaceuticals and personal care products in the groundwater: a review. Emerg. Contam. 1(1), 14–24 (2015). https://doi.org/10.1016/j.emcon.2015.07.001
G.V. de Jesus, C.M.M. Almeida, A. Rodrigues, E. Ferreira, M.J. Benoliel, V.V. Cardoso, Occurrence of pharmaceuticals in a water supply system and related human health risk assessment. Water Res. 72, 199–208 (2015). https://doi.org/10.1016/j.watres.2014.10.027
Z. Li, X. Xiang, M. Li, Y. Ma, J. Wang, X. Liu, Occurrence and risk assessment of pharmaceuticals and personal care products and endocrine disrupting chemicals in reclaimed water and receiving groundwater in China. Ecotoxicol. Environ. Saf. 119, 74–80 (2015). https://doi.org/10.1016/j.ecoenv.2015.04.031
L.M. Bexfield, P.L. Toccalino, K. Belitz, W.T. Foreman, E.T. Furlong, Hormones and pharmaceuticals in groundwater used as a source of drinking water across the United States. Environ. Sci. Technol. 53(6), 2950–2960 (2019). https://doi.org/10.1021/acs.est.8b05592
B.M. Sharma, J. Bečanová, M. Scheringer, et al., Health and ecological risk assessment of emerging contaminants (pharmaceuticals, personal care products, and artificial sweeteners) in surface and groundwater (drinking water) in the Ganges River Basin. India. Sci Total Environ. 646, 1459–1467 (2019). https://doi.org/10.1016/j.scitotenv.2018.07.235
L.A. Kristofco, B.W. Brooks, Global scanning of antihistamines in the environment: analysis of occurrence and hazards in aquatic systems. Sci. Total Environ. 592, 477–487 (2017). https://doi.org/10.1016/j.scitotenv.2017.03.120
Murdoch K (2015) Pharmaceutical pollution in the environment: issues for Australia, New Zealand and Pacific Island countries. Natl Toxics Netw (May):36. http://www.ntn.org.au/wp/wp-content/uploads/2015/05/NTN-Pharmaceutical-Pollution-in-the-Environment-2015-05.pdf. accessed 5th January 2020
L.A. Schaider, R.A. Rudel, J.M. Ackerman, S.C. Dunagan, J.G. Brody, Pharmaceuticals, perfluorosurfactants, and other organic wastewater compounds in public drinking water wells in a shallow sand and gravel aquifer. Sci. Total Environ. 468-469, 384–393 (2014). https://doi.org/10.1016/j.scitotenv.2013.08.067
L. Tong, S. Huang, Y. Wang, H. Liu, M. Li, Occurrence of antibiotics in the aquatic environment of Jianghan Plain, central China. Sci. Total Environ. 497-498, 180–187 (2014). https://doi.org/10.1016/j.scitotenv.2014.07.068
Maycock DS, Watts CD. (2011) Pharmaceuticals in drinking water. Encycl Environ Health. Published online 472-484. https://doi.org/10.1016/B978-0-444-52272-6.00457-8
Beere W, Mullet S, Wingstedt E, Berg Ø, Savoainen S, Lahti T. (2010)Model-based condition monitoring techniques for balance of plant analysis using tempo. 7th Int Top Meet Nucl Plant Instrumentation, Control Human-Machine Interface Technol 2010, NPIC HMIT 2010 3(2):1920-1924.
Groundwater P (n.d.) Protecting Groundwater for Health.
M.N. Fienen, B.T. Nolan, D.T. Feinstein, Evaluating the sources of water to wells: three techniques for metamodeling of a groundwater flow model. Environ. Model. Softw. 77, 95–107 (2016). https://doi.org/10.1016/j.envsoft.2015.11.023
P.C. Von der Ohe, V. Dulio, J. Slobodnik, E. De Deckere, R. Kühne, R.-U. Ebert, et al., A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European water framework directive. Sci. Total Environ. 409(11), 2064–2077 (2011)
Mittal PKM and Atul K. Pharmaceuticals and personal care products ( PPCPs ) residues in water environment of India: a neglected but sensitive issue Pravin K Mutiyar and Atul K Mittal Department of Civil Engineering Indian Institute of Technology Delhi, Hauz Khas , New Delhi 1. 2013;110016
D. Kasel, S.A. Brandford, J. Simunek, M. Heggen, H. Vereecken, E. Klumpp, Transport and retention of multi-walled carbon nanotubes in saturated porous media: effects of input concentration and grain size. Water Res. 47(2), 933–944 (2013)
Y. Liang, S.A. Bradford, H. Vereecken, E. Klumpp, Sensitivity of the transport and retention of stabilized silver nanoparticles to physicochemical factors. Water Res. 47(7), 2572–2582 (2013)
T. Azuma, H. Ishiuchi, T. Inoyama, Y. Teranishi, M. Yamaoka, T. Sato, Y. Mino, Occurrence and fate of selected anticancer, antimicrobial, and psychotropic pharmaceuticals in an urban river in a subcatchment of the Yodo River basin. Japan Environmental Science and Pollution Research 22(23), 18676–18686 (2015)
M. Abtahi, S. Dobaradaran, M. Torabbeigi, et al., Health risk of phthalates in water environment: occurrence in water resources, bottled water, and tap water, and burden of disease from exposure through drinking water in tehran. Iran. Environ Res. 173(January), 469–479 (2019). https://doi.org/10.1016/j.envres.2019.03.071
R. Kumar, P. Kumar, Wastewater stabilisation ponds: removal of emerging contaminants. J Sustain Dev Energy, Water Environ Syst 8(2), 344–359 (2020). https://doi.org/10.13044/j.sdewes.d7.0291
A.J. Swallow, An introduction to radiation chemistry. Int. J. Radiat. Biol. 30(4), 399–399 (1976). https://doi.org/10.1080/09553007614551181
X. Lin, J. Xu, A.A. Keller, et al., Occurrence and risk assessment of emerging contaminants in a water reclamation and ecological reuse project. Sci. Total Environ. 744, 140977 (2020). https://doi.org/10.1016/j.scitotenv.2020.140977
Acknowledgements
The authors are grateful to the Department of Chemical Engineering, School of Technology, Pandit Deendayal Energy University, for the permission to publish this research.
Author information
Authors and Affiliations
Contributions
All the authors make a substantial contribution to this manuscript. YV, VP, PP, MG, CG, KM, and MS participated in drafting the manuscript. YV, VP, PP, MG, CG, KM, and MS wrote the main manuscript. All the authors discussed the results and implication on the manuscript at all stages.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Vaddoriya, Y., Patel, V., Patel, P. et al. Origin, fate, and risk assessment of emerging contaminants in groundwater bodies: a holistic review. emergent mater. 4, 1275–1294 (2021). https://doi.org/10.1007/s42247-021-00268-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s42247-021-00268-5