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Periostin concentrations in childhood-onset craniopharyngioma patients

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Abstract

Purpose

Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD.

Methods

A cross-sectional study on 35 patients with sellar masses (SMP) recruited in the German Childhood Craniopharyngioma Registry (32 CP, 2 xanthogranuloma, 1 pilocytic astrocytoma), three short-statured patients with isolated growth hormone deficiency, five short-statured patients with normal findings in GH-stimulating tests and decreased insulin-like growth factor (IGF)-1 and seven healthy controls. Periostin was measured by Elisa in serum, urine and saliva.

Results

Periostin serum, urine and saliva concentrations in CP were similar to concentrations of the other groups. Hypothalamic involvement/hypothalamic lesions, degree of obesity as well as hepatic enzymes were not associated with elevated periostin concentrations. Due to low patient numbers with pathological hepatic parameters, missing imaging data on the degree of steatosis hepatis and the lack of histological proof of NAFLD, no definitive conclusions can be drawn from measured periostin concentrations in serum. Interestingly, the subgroup of patients with decreased IGF-1 levels showed elevated concentrations of serum periostin when compared with other groups.

Conclusions

In CP, periostin concentrations are not associated with known risk factors for NAFLD such as hepatic and metabolic parameters, obesity and hypothalamic lesions. Accordingly, periostin does not seem to be a suitable marker for NAFLD in CP.

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Acknowledgements

The authors want to thank all participating colleagues for recruiting patients in Hit-Endo and KRANIOPHARYNGEOM 2000/2007, and the patients and their parents for participating in this study.

Funding

This study was funded by a Grant (DKS2014.13) of the German Childhood Cancer Foundation, Bonn, Germany. AB is supported by a fellowship grant of the European Society for Paediatric Endocrinology (ESPE).

Author information

Authors and Affiliations

  1. Department of Pediatrics and Pediatric Hematology/Oncology, University Children′s Hospital, Klinikum Oldenburg AöR, 26133, Oldenburg, Germany

    K. Heinks, C. De Schutter-Nüsse, S. Boekhoff, A. Bogusz, J. Peng & H. L. Müller

  2. European Medical School Oldenburg - Groningen, Carl von Ossietzky University, 26129, Oldenburg, Germany

    C. De Schutter-Nüsse

  3. Department of Endocrinology and Diabetology, The Children′s Memorial Health Institute, 04-730, Warsaw, Poland

    A. Bogusz

  4. Department of Gastroenterology, Zhejiang University, Hangzhou, 310003, China

    J. Zhu

  5. Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

    J. Peng

Authors
  1. K. Heinks
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  2. C. De Schutter-Nüsse
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  3. S. Boekhoff
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  4. A. Bogusz
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  5. J. Zhu
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  6. J. Peng
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  7. H. L. Müller
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Contributions

KH researched the data and wrote the manuscript. CSN contributed to the data collection and discussion and reviewed/edited the manuscript. SB conducted and supervised multicenter data collecting and reviewed/edited the manuscript. AB participated in data analyses, and reviewed/edited the manuscript. JZ performed periostin measurements using ELISA. JP participated in data analyses, and reviewed/edited the manuscript. HLM initiated and conducted the multicenter trials Hit-Endo KRANIOPHARYNGEOM 2000/2007, contributed to the analytical plan and discussion and reviewed/edited the manuscript.

Corresponding author

Correspondence to H. L. Müller.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in our study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Written parental and/or patient informed consent was obtained in all cases. The study was approved by the local standing-committee on ethical practice (University Oldenburg, Germany).

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Heinks, K., De Schutter-Nüsse, C., Boekhoff, S. et al. Periostin concentrations in childhood-onset craniopharyngioma patients. J Endocrinol Invest 42, 815–824 (2019). https://doi.org/10.1007/s40618-018-0987-9

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  • DOI: https://doi.org/10.1007/s40618-018-0987-9

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