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Pegylated Liposomal Doxorubicin: A Guide to Its Use in Various Malignancies

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Abstract

Pegylated liposomal doxorubicin (Caelyx® [EU], Doxil® [USA]) represents an improved formulation of conventional doxorubicin, with reduced cardiotoxicity and an improved pharmacokinetic profile. As shown by evidence from clinical trials, intravenous pegylated liposomal doxorubicin is a useful option in the treatment of various malignancies, including metastatic breast cancer, ovarian cancer, multiple myeloma, and AIDS-related Kaposi sarcoma. It has a favourable safety profile relative to conventional doxorubicin and other available chemotherapy agents.

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Disclosure

This article was updated from Drugs 2011; 71(18):2531–58 [1]. The preparation of these reviews was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on the articles. Changes resulting from comments received were made by the authors on the basis of scientific and editorial merit.

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Authors and Affiliations

  1. Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand

    Katherine A. Lyseng-Williamson, Sean T. Duggan & Gillian M. Keating

Authors
  1. Katherine A. Lyseng-Williamson
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  2. Sean T. Duggan
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  3. Gillian M. Keating
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Corresponding author

Correspondence to Katherine A. Lyseng-Williamson.

Additional information

The manuscript was reviewed by: G. Ferrandina, Department of Oncology, Catholic University of the Sacred Heart, Campobasso, Italy; D. Lorusso, Department of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome, Italy.

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Lyseng-Williamson, K.A., Duggan, S.T. & Keating, G.M. Pegylated Liposomal Doxorubicin: A Guide to Its Use in Various Malignancies. BioDrugs 27, 533–540 (2013). https://doi.org/10.1007/s40259-013-0070-1

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