Abstract
Background
Genome (GS) and exome sequencing (ES) could potentially identify pathogenic variants with greater sensitivity than chromosomal microarray (CMA) in autism spectrum disorder (ASD) but are costlier and result interpretation can be uncertain. Study objective was to compare the costs and outcomes of four genetic testing strategies in children with ASD.
Methods
A microsimulation model estimated the outcomes and costs (in societal and public payer perspectives in Ontario, Canada) of four genetic testing strategies: CMA for all, CMA for all followed by ES for those with negative CMA and syndromic features (CMA+ES), ES or GS for all.
Results
Compared to CMA, the incremental cost-effectiveness ratio (ICER) per additional child identified with rare pathogenic variants within 18 months of ASD diagnosis was $CAN5997.8 for CMA+ES, $CAN13,504.2 for ES and $CAN10,784.5 for GS in the societal perspective. ICERs were sensitive to changes in ES or GS diagnostic yields, wait times for test results or pre-test genetic counselling, but were robust to changes in the ES or GS costs.
Conclusion
Strategic integration of ES into ASD care could be a cost-effective strategy. Long wait times for genetic services and uncertain utility, both clinical and personal, of sequencing results could limit broader clinical implementation.
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Data Availability Statement
The TreeAge model and R code for analyzing the data are available at tspace.library.utoronto.ca/handle/1807/80706, a public repository for the University of Toronto.
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Acknowledgements
The authors would like to acknowledge inputs from Robyn Hayeems, Ny Hoang, Cheryl Shuman and Kate Tsiplova on the parameters used in the model.
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All authors (TY, MTC, PS, WJU) contributed to the conceptualization of model, interpretation of findings, editing of the manuscript and provided final approval of the paper. TY and WJU were responsible for model building, data analysis and drafting the manuscript.
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TY was supported through the Canada Institutes of Health Research Autism Research Training Program, Doctoral Autism Scholars Award, Ontario Graduate Scholarship and RestraComp Hospital for Sick Children Foundation Student Scholarship Program. No other funding was received for this study.
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All authors (TY, MTC, PS, WJU) declare no conflicts of interest.
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Yuen, T., Carter, M.T., Szatmari, P. et al. Cost-effectiveness of Genome and Exome Sequencing in Children Diagnosed with Autism Spectrum Disorder. Appl Health Econ Health Policy 16, 481–493 (2018). https://doi.org/10.1007/s40258-018-0390-x
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DOI: https://doi.org/10.1007/s40258-018-0390-x