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A Review on Basic Biology of Bacterial Biofilm Infections and Their Treatments by Nanotechnology-Based Approaches

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Abstract

Biofilms are responsible for causing 80% of human infections including chronic infections like-cystic fibrosis, endocarditis and osteomyelitis. The growing ability of the biofilm to resist most of the available antibiotics has caused a serious threat to different life forms. Plenty of research work has already been reported, and some are ongoing to combat this serious health issue worldwide. Recent developments in nanotechnology have given a great boost in dealing biofilm infections. The unique size-dependent properties for antibacterial and antibiofilm activities provide the nanoparticles better options to eradicate biofilms. Here, the authors have discussed the basic biology of bacterial biofilm and their impact on human health. In addition, different nanotechnology-based strategies to overcome serious health issues caused by biofilm infections have been highlighted.

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Acknowledgements

The authors Debjani Banerjee and P. M. Shivapriya are thankful to MHRD, Govt. of India and Pavan Kumar Gautam to DST for fellowship. They would like to acknowledge Indian Institute of Information Technology, Allahabad, for providing Institutional Seed Grant project for financial assistance.

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  1. Department of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad, 211012, India

    Debjani Banerjee, P. M. Shivapriya, Pavan Kumar Gautam, Krishna Misra, Amaresh Kumar Sahoo & Sintu Kumar Samanta

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  1. Debjani Banerjee
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  2. P. M. Shivapriya
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  3. Pavan Kumar Gautam
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Correspondence to Sintu Kumar Samanta.

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Significance statement Biofilm infections have become a serious health issue worldwide. The increased resistance of biofilm to conventional antibiotics is major issue of concern. Hence, there is an urgent need to develop new strategies to combat the biofilm infections. In this pursuit, nanotechnology provides different approaches which confer better opportunities to resolve this problem.

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Banerjee, D., Shivapriya, P.M., Gautam, P.K. et al. A Review on Basic Biology of Bacterial Biofilm Infections and Their Treatments by Nanotechnology-Based Approaches. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 90, 243–259 (2020). https://doi.org/10.1007/s40011-018-01065-7

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