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Cell penetrating peptides as an innovative approach for drug delivery; then, present and the future

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Abstract

With the rapid development of biotechnology, various macromolecules as therapeutic agents have made drug delivery an important field of research. However, these are being commercialized as injection form. Due to low patient compliance, various non-invasive routes emerge as a promising strategy. Cell penetrating peptides (CPPs) have shown to assist in efficient and non-toxic manner. They provide ample evidence to deliver of many cargoes ranging from small molecules to proteins and even nanocarriers for various applications. This review briefly discusses about introduction of CPPs, history, cellular uptake mechanisms and various possible alternative routes for CPP-conjugated drug delivery system. It also aims to give a perspective on present status of CPP-mediated research, clinical development, possible obstacles as well as future opportunities. Thus, development of novel CPPs that are safe, tissue-specific and highly efficient will be exemplified and become ideal vehicles for therapeutic delivery in near future.

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Acknowledgments

All authors declare (S. Bashyal, G. Noh, T. Keum, Y.W. Choi and S. Lee) that they have no conflict of interest. This article does not contain any studies with human and animal subjects performed by any of the authors.

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  1. College of Pharmacy, Keimyung University, 1095 Dalgubeol-daero, Daegu, 704-701, Republic of Korea

    Santosh Bashyal, Gyubin Noh, Taekwang Keum & Sangkil Lee

  2. College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong, Dongjak-gu, Seoul, 156-756, Republic of Korea

    Young Wook Choi

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Bashyal, S., Noh, G., Keum, T. et al. Cell penetrating peptides as an innovative approach for drug delivery; then, present and the future. Journal of Pharmaceutical Investigation 46, 205–220 (2016). https://doi.org/10.1007/s40005-016-0253-0

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