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Nanoparticle-based combination drug delivery systems for synergistic cancer treatment

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Abstract

Despite being a leading cause of death worldwide, cancer remains difficult to treat due to the development of drug resistance and severe adverse effects associated with conventional chemotherapy. Hence, combination chemotherapy is theoretically advantageous owing to the synergistic effects of drugs and suppression of drug resistance. Nanoparticle-mediated chemotherapeutic delivery is a promising approach for the effective treatment of various cancers because it may simultaneously enhance therapeutic effects and reduce side effects. The loading of multiple chemotherapeutic agents to these systems could additionally improve the antineoplastic efficacy. This review highlights recent advances in combination chemotherapy using small-molecule chemotherapeutic agents via nanocarrier systems, e.g., liposomes, polymeric micelles, dendrimers, polymer-drug conjugates, and mesoporous silica nanoparticles. Specifically, it emphasizes the unique properties of these systems that make them amenable to optimized treatments with respect to efficacy and safety and clarifies areas in which current therapeutic strategies can be improved.

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Acknowledgments

This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP) (No. 2015R1A2A2A01004118, 2015R1A2A2A04004806).

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The authors have no conflict of interest.

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    Authors and Affiliations

    1. College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 712-749, South Korea

      Ju Yeon Choi, Raj Kumar Thapa, Chul Soon Yong & Jong Oh Kim

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    1. Ju Yeon Choi
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    2. Raj Kumar Thapa
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    3. Chul Soon Yong
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    4. Jong Oh Kim
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    Correspondence to Chul Soon Yong or Jong Oh Kim.

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    Ju Yeon Choi and Raj Kumar Thapa contributed equally

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    Choi, J.Y., Thapa, R.K., Yong, C.S. et al. Nanoparticle-based combination drug delivery systems for synergistic cancer treatment. Journal of Pharmaceutical Investigation 46, 325–339 (2016). https://doi.org/10.1007/s40005-016-0252-1

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    • DOI: https://doi.org/10.1007/s40005-016-0252-1

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