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Quantitative evaluation of mucoadhesive polymers to compare the mucoadhesion

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Abstract

Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers. Carbomer 940, chitosan, hydroxypropylcellulose, and sodium carboxymethylcellulose were used as mucoadhesive polymers. The mucoadhesion by tensile strength tester using rat stomach were in the order of hydroxypropylcellulose, sodium carboxymethylcellulose, chitosan and carbomer 940. Similarly, in mucin particle method, mucoadhesion was in order of hydroxypropylcellulose, sodium carboxymethylcellulose, chitosan and carbomer 940. The viscosity of mixture with mucin solution was in the order of hydroxypropylcellulose, sodium carboxymethylcellulose, carbomer 940 and chitosan. Still, there is little on the quantitative comparison of individual mucoadhesive polymer using the same mucoadhesion test. So, this study could be a basic data for the selection of mucoadhesive polymer.

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Acknowledgments

All authors (C.A. Lee, B.S. Kim, C.W. Cho) declare that they have no conflict of interest. This study was supported by Chungnam National University.

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    Authors and Affiliations

    1. College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea

      Cho-A Lee, Bo-Sik Kim & Cheong-Weon Cho

    2. College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 220 Gungdong, Yuseonggu, Daejeon, 305-764, South Korea

      Cheong-Weon Cho

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    1. Cho-A Lee
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    Correspondence to Cheong-Weon Cho.

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    Cho-A Lee and Bo-Sik Kim equally contribute to this work.

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    Lee, CA., Kim, BS. & Cho, CW. Quantitative evaluation of mucoadhesive polymers to compare the mucoadhesion. Journal of Pharmaceutical Investigation 46, 189–194 (2016). https://doi.org/10.1007/s40005-016-0233-4

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