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Coenzyme Q10 oral bioavailability: effect of formulation type

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Abstract

Coenzyme Q10 (Q10) has a poor bioavailability due to its very low aqueous solubility and high molecular weight. The purpose of this review is to discuss the different types of Q10 drug delivery systems (DDS) ranging from the simple oily dispersions to the nanotechnology-oriented systems such as nanocrystals, self-nanoemulsified drug delivery systems, etc. to overcome the solubility issue. The basics of these approaches were discussed in relationship to the effect of Q10 absorption. For that purpose, the percentage of the drug absorbed to the blood stream out of the administered dose was calculated as the fraction absorbed (Fa%). The Fa% for the nanoemulsions discussed in this article did not correlate with droplet size. In human studies most of the delivery systems had a low Fa% being in the range from 1.53 to 12.48 %. The highest Fa% value was found to be for the self-emulsified drug delivery systems (SEDDS). In dogs studies, the Fa% values ranged between 0.28 (cyclodextrin complex) and 4.8 %. In rat studies, some other DDS like emulsions and solubilized formulations showed Fa% of around 0.22 %. The relationship between the average Fa% in rats, dogs and humans was found to be 1:15:20. One recent study applied both oral and intravenous delivery of Q10; the orally tested SEDDS formulation had an absolute bioavailability of 2.2 % corresponding to Fa% = 0.04 %. The studies with Q10 formulations based only on in vitro data were also discussed and assessed regarding the influence of formulation on solubility, release and/or uptake.

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References

  • Abdin AA, Hamouda HE (2008) Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism. Neuropharmacology 55(8):1340–1346

    PubMed  CAS  Google Scholar 

  • Åberg F, Appelkvist EL, Dallner G, Ernster L (1992) Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 295(2):230–234

    PubMed  Google Scholar 

  • Al-Hasso S (2000) Coenzyme Q10: a review. Hosp Pharm 36(1):51–55

    Google Scholar 

  • Ankola DD, Viswanad B, Bhardwaj V, Ramarao P, Kumar MNVR (2007) Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? Eur J Pharm Biopharm 67(2):361–369

    PubMed  CAS  Google Scholar 

  • Badmaev V, Majeed M, Prakash L (2000) Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementation. J Nutr Biochem 11(2):109–113. doi:10.1016/s0955-2863(99)00074-1

    PubMed  CAS  Google Scholar 

  • Balakrishnan P, Lee B-J, Oh DH, Kim JO, Lee Y-I, Kim D-D, Jee J-P, Lee Y-B, Woo JS, Yong CS, Choi H-G (2009) Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm 374(1–2):66–72

    PubMed  CAS  Google Scholar 

  • Beg S, Javed S, Kohli K (2010) Bioavailability enhancement of coenzyme Q10: an extensive review of patents. Recent Pat Drug Deliv Formul 4(3):245–255

    PubMed  CAS  Google Scholar 

  • Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, Tiano L, Littarru G (2006) Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J 27(22):2675

    PubMed  CAS  Google Scholar 

  • Bhagavan HN, Chopra RK (2006) Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 40(5):445–453

    PubMed  CAS  Google Scholar 

  • Bhagavan HN, Chopra RK (2007) Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 7(Supplement 1):S78–S88. doi:10.1016/j.mito.2007.03.003

    PubMed  CAS  Google Scholar 

  • Bhagavan HN, Chopra RK, Craft NE, Chitchumroonchokchai C, Failla ML (2007) Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model. Int J Pharm 333(1–2):112–117

    PubMed  CAS  Google Scholar 

  • Bhandari KH, Newa M, Kim JA, Yoo BK, Woo JS, Lyoo WS, Lim HT, Choi HG, Yong CS (2007) Preparation, characterization and evaluation of coenzyme Q10 binary solid dispersions for enhanced solubility and dissolution. Biol Pharm Bull 30(6):1171–1176

    PubMed  CAS  Google Scholar 

  • Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF (2002) Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302(2):645–650. doi:10.1124/jpet.102.034728

    PubMed  CAS  Google Scholar 

  • Bijsterbosch MK, Duursma AM, Bouma JMW, Gruber M (1981) The plasma volume of the Wistar rat in relation to the body weight. Cell Mol Life Sci 37(4):381–382. doi:10.1007/bf01959874

    CAS  Google Scholar 

  • Bliznakov EG (2002) Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case: a modern Pandora’s box. Biomed Pharmacother 56:56–59

    PubMed  CAS  Google Scholar 

  • Bogentoft C, Edlund P, Olsson B, Wilund L, Westensen K (1991) Biopharmaceutical aspects of intravenous and oral administration of coenzyme Q10. In: Folkers K, Littarru GP, Yamagami T (eds) Biomedical and clinical aspects of coenzyme Q10. Elsevier Science, Amsterdam, pp 215–224

    Google Scholar 

  • Boreková M, Hojerová J, Koprda V, Bauerová K (2008) Nourishing and health benefits of coenzyme Q10: a review. Czech J Food Sci 26(4):229–241

    Google Scholar 

  • Carli F, Chiellini E (2003) Pharmaceutical composition comprising an oil/water/oil double microemulsion incorporated into a solid support

  • Carli F, Chiellini EE, Bellich B, Macchiavelli S, Cadelli G (2005) Ubidecarenone nanoemulsified composite systems. Int J Pharm 291(1–2):113–118

    PubMed  CAS  Google Scholar 

  • Chiou WL, Riegelman S (1971) Pharmaceutical applications of solid dispersion systems. J Pharm Sci 60(9):1281–1302. doi:10.1002/jps.2600600902

    PubMed  CAS  Google Scholar 

  • Chopra R, Goldman R, Sinatra S, Bhagavan H (1998) Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res 68(2):109–113

    PubMed  CAS  Google Scholar 

  • Constantinescu R, McDermott MP, DiCenzo R, de Blieck EA, Hyson HC, Beal MF, Bednarczyk EM, Bogdanov M, Metakis LJ, Browne SE, Lorenzo BJ, Ravina B, Kieburtz K (2007) A randomized study of the bioavailability of different formulations of coenzyme Q10 (Ubiquinone). J Clin Pharmacol 47(12):1580–1586. doi:10.1177/0091270007307571

    PubMed  CAS  Google Scholar 

  • Crane FL (2001) Biochemical functions of coenzyme Q10. J Am Coll Nutr 20(6):591–598

    PubMed  CAS  Google Scholar 

  • Crane FL, Hatefi Y, Lester RL, Widmer C (1957) Isolation of a quinone from beef heart mitochondria. Biochim Biophys Acta 25(1):220–221

    PubMed  CAS  Google Scholar 

  • Deichmann R, Lavie C, Andrews S (2010) Coenzyme Q10 and statin-induced mitochondrial dysfunction. Ochsner J 10(1):16–21

    PubMed  Google Scholar 

  • Evans M, Baisley J, Barss S, Guthrie N (2009) A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. J Funct Foods 1(1):65–73. doi:10.1016/j.jff.2008.09.010

    CAS  Google Scholar 

  • Folkers K, Moesgaard S, Morita M (1994) A one year bioavailability study of coenzyme Q10 with 3 months withdrawal period. Mol Aspects Med 15(Supplement 1):s281–s285. doi:10.1016/0098-2997(94)90039-6

    PubMed  CAS  Google Scholar 

  • Franke AA, Morrison CM, Bakke JL, Custer LJ, Li X, Cooney RV (2010) Coenzyme Q10 in human blood: native levels and determinants of oxidation during processing and storage. Free Radic Biol Med 48(12):1610–1617. doi:10.1016/j.freeradbiomed.2010.03.002

    PubMed  CAS  Google Scholar 

  • Frei B, Kim MC, Ames BN (1990) Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci USA 87(12):4879

    PubMed  CAS  Google Scholar 

  • Fu X, Ji R, Dam J (2009) Acute, subacute toxicity and genotoxic effect of Bio-Quinone® Q10 in mice and rats. Regul Toxicol Pharmacol 53(1):1–5. doi:10.1016/j.yrtph.2008.09.003

    PubMed  CAS  Google Scholar 

  • Gao X, Nishimura K, Hirayama F, Arima H, Uekama K, Schmid G, Terao K, Nakata D, Fukumi H (2006) Enhanced dissolution and oral bioavailability of coenzyme Q10 in dogs obtained by inclusion complexation with -cyclodextrin. Asian J Pharm Sci 1(2):95–102

    CAS  Google Scholar 

  • Geromel V, Darin N, Chrétien D, Bénit P, DeLonlay P, Rötig A, Munnich A, Rustin P (2002) Coenzyme Q10 and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits. Mol Genet Metab 77(1–2):21–30. doi:10.1016/s1096-7192(02)00145-2

    PubMed  CAS  Google Scholar 

  • Goldman R (2000) Method for enhancing dissolution properties of relatively insoluble dietary supplements and product incorporating same. United States Patent

  • Greenberg S, Frishman W (1988) Coenzyme Q10: a new drug for myocardial ischemia? Med Clin North Am 72(1):243

    PubMed  CAS  Google Scholar 

  • Greenberg S, Frishman WH (1990) Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 30(7):569–608

    Google Scholar 

  • Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, Littarru GP, Döring F (2005) Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Int J Biochem Cell Biol 37(6):1208–1218. doi:10.1016/j.biocel.2004.11.017

    PubMed  CAS  Google Scholar 

  • Haas RH (2007) The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. Mitochondrion 7(Supplement 1):S136–S145. doi:10.1016/j.mito.2007.03.008

    PubMed  CAS  Google Scholar 

  • Harata K (1998) Structural aspects of stereodifferentiation in the solid state. Chem Rev 98(5):1803–1828. doi:10.1021/cr9700134

    PubMed  CAS  Google Scholar 

  • Hargreaves IP (2003) Ubiquinone: cholesterol’s reclusive cousin. Ann Clin Biochem 40(3):207–218. doi:10.1258/000456303321610493

    PubMed  CAS  Google Scholar 

  • Hargreaves IP, Duncan AJ, Heales SJR, Land JM (2005) The Effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. Drug Saf 28:659–676

    PubMed  CAS  Google Scholar 

  • Hatanaka J, Kimura Y, Lai-Fu Z, Onoue S, Yamada S (2008) Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q(10) formulations. Int J Pharm 363(1–2):112–117

    PubMed  CAS  Google Scholar 

  • Henriksen JE, Andersen CB, Hother-Nielsen O, Vaag A, Mortensen SA, Beck-Nielsen H (1999) Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus. Diabet Med 16(4):312–318. doi:10.1046/j.1464-5491.1999.00064.x

    PubMed  CAS  Google Scholar 

  • Hidaka T, Fujii K, Funahashi I, Fukutomi N, Hosoe K (2008) Safety assessment of coenzyme Q10 (CoQ10). BioFactors 32(1–4):199–208. doi:10.1002/biof.5520320124

    PubMed  CAS  Google Scholar 

  • Hodges S, Hertz N, Lockwood K, Lister R (1999) CoQ10: could it have a role in cancer management? BioFactors 9(2):365–370

    PubMed  CAS  Google Scholar 

  • Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M (2007) Study on safety and bioavailability of ubiquinol (Kaneka QH(TM)) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 47(1):19–28. doi:10.1016/j.yrtph.2006.07.001

    PubMed  CAS  Google Scholar 

  • Hsu C-H, Cui Z, Mumper R, Jay M (2003) Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors. AAPS PharmSciTech 4(3):24–35. doi:10.1208/pt040332

    Google Scholar 

  • Hyson H, Kieburtz K, Shoulson I, McDermott M, Ravina B, de Blieck E, Cudkowicz M, Ferrante R, Como P, Frank S (2010) Safety and tolerability of high-dosage coenzyme Q10 in Huntington’s disease and healthy subjects. Mov Disord 25(12):1924–1928. doi:10.1002/mds.22408

    PubMed  Google Scholar 

  • Ikematsu H, Nakamura K, Harashima S-i, Fujii K, Fukutomi N (2006) Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 44(3):212–218

    PubMed  CAS  Google Scholar 

  • Itagaki S, Ochiai A, Kobayashi M, Sugawara M, Hirano T, Iseki K (2008) Interaction of coenzyme Q10 with the intestinal drug transporter P-Glycoprotein. J Agric Food Chem 56(16):6923–6927. doi:10.1021/jf800992p

    PubMed  CAS  Google Scholar 

  • Itagaki S, Ochiai A, Kobayashi M, Sugawara M, Hirano T, Iseki K (2010) Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2. Food Chem 120(2):552–555. doi:10.1016/j.foodchem.2009.10.052

    CAS  Google Scholar 

  • Jeya M, Moon H-J, Lee J-L, Kim I-W, Lee J-K (2010) Current state of coenzyme Q(10) production and its applications. Appl Microbiol Biotechnol 85(6):1653–1663

    PubMed  CAS  Google Scholar 

  • Jino J (2010) NanoSolve: New Age Technology to defy aging. Knol. http://knol.google.com/k/jesse-jino/nanosolve/2sxvfhs95espm/3. Accessed 10 Mar 2011

  • Joshi SS, Sawant SV, Shedge A, Halpner AD (2003) Comparative bioavailability of 2 novel coenzyme Q10 preparations in humans. Int J Clin Pharmacol Ther 41(1):42–48

    PubMed  CAS  Google Scholar 

  • Kaikkonen J, Nyyssönen K, Porkkala-Sarataho E, Poulsen HE, Metsä-Ketelä T, Hayn M, Salonen R, Salonen JT (1997) Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL + LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 22(7):1195–1202. doi:10.1016/s0891-5849(96)00549-7

    PubMed  CAS  Google Scholar 

  • Kaikkonen J, Nyyssönen K, Tomasi A, Iannone A, Tuomainen T, Porkkala-Sarataho E, Salonen J (2000) Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study. Free Radic Res 33(3):329

    PubMed  CAS  Google Scholar 

  • Kaikkonen J, Tuomainen T-P, Nyyssonen K, Salonen JT (2002) Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels. Free Radic Res 36(4):389–397

    PubMed  CAS  Google Scholar 

  • Kalenikova E, Gorodetskaya E, Medvedev O (2009) Bioavailability of coenzyme Q10 in various pharmaceutical formulations. Pharm Chem J 43(8):468–471. doi:10.1007/s11094-009-0330-z

    CAS  Google Scholar 

  • Katayama K, Fujita T (1972) Studies on the lymphatic absorption of 10, 20-(3H)-coenzyme Q10 in rats. Chem Pharm Bull (Tokyo) 250:2585–2592

    Google Scholar 

  • Khan M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, Schmidt F, Klapp B, Reisshauer A, Mazurek B (2007) A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg 136(1):72

    PubMed  Google Scholar 

  • Khatta M, Alexander BS, Krichten CM, Fisher ML, Freudenberger R, Robinson SW, Gottlieb SS (2000) The effect of coenzyme Q10 in patients with congestive heart failure. Ann Intern Med 132(8):636–640

    PubMed  CAS  Google Scholar 

  • Kommuru TR, Gurley B, Khan Ma, Reddy IK (2001) Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm 212(2):233–246

    PubMed  CAS  Google Scholar 

  • Kumar A, Kaur H, Devi P, Mohan V (2009) Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther 124(3):259–268. doi:10.1016/j.pharmthera.2009.07.003

    PubMed  CAS  Google Scholar 

  • Lacy JE, Embleton JK, Perry EA (2000) Delivery systems for hydrophobic drugs. United States Patent

  • Langsjoen PH (1994) Introduction to coenzyme Q10. http://faculty.washington.edu/ely/coenzq10.html. Accessed 08 Feb 2011

  • Langsjoen PH, Langsjoen AM (2003) The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. BioFactors 18(1–4):101–111

    PubMed  CAS  Google Scholar 

  • Levy HB, Kohlhaas HK (2006) Considerations for supplementing with coenzyme Q10 during statin therapy. Ann Pharmacother 40(2):290–294. doi:10.1345/aph.1G409

    PubMed  CAS  Google Scholar 

  • Littarru GP, Tiano L (2005) Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care 8(6):641–646. doi:10.1016/j.nut.2009.08.008

    PubMed  CAS  Google Scholar 

  • Littarru GP, Tiano L (2010) Clinical aspects of coenzyme Q10: an update. Nutrition 26(3):250–254. doi:10.1016/j.nut.2009.08.008

    PubMed  CAS  Google Scholar 

  • Liu Z-X, Artmann C (2009) Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Altern Ther Health Med 15(2):42–46

    PubMed  Google Scholar 

  • Lönnrot K, Metsä-Ketelä T, Molnár G, Ahonen J, Latvala M, Peltola J, Pietilä T, Alho H (1996) The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity. Free Radic Biol Med 21(2):211–217

    PubMed  Google Scholar 

  • Lönnrot K, Tolvanen J-P, Pörsti I, Ahola T, Hervonen A, Alho H (1998) Coenzyme Q10 supplementation and recovery from ischemia in senescent rat myocardium. Life Sci 64(5):315–323. doi:10.1016/s0024-3205(98)00567-0

    Google Scholar 

  • López-Lluch G, Rodríguez-Aguilera JC, Santos-Ocaña C, Navas P (2010) Is coenzyme Q a key factor in aging? Mech Ageing Dev 131(4):225–235. doi:10.1016/j.mad.2010.02.003

    PubMed  Google Scholar 

  • Lyon W, Van den Brink O, Pepe S, Wowk M, Marasco S, Rosenfeldt F (2001) Similar therapeutic serum levels attained with emulsified and oil based preparations of coenzyme Q10. Asia Pac J Clin Nutr 10(3):212–215

    PubMed  CAS  Google Scholar 

  • Mancuso M, Orsucci D, Calsolaro V, Choub A, Siciliano G (2009) Coenzyme Q10 and neurological diseases. Pharmaceuticals 2(3):134–149

    CAS  Google Scholar 

  • Marcoff L, Thompson PD (2007) The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol 49(23):2231–2237. doi:10.1016/j.jacc.2007.02.049

    PubMed  CAS  Google Scholar 

  • Mauludin R (2008) Nanosuspensions of poorly soluble drugs for oral administration. Ph.D. thesis, Freie Universität Berlin, Berlin

  • Miles MV (2007) The uptake and distribution of coenzyme Q(10). Mitochondrion 7(Supplement 1):S72–S77. doi:10.1016/j.mito.2007.02.012

    PubMed  CAS  Google Scholar 

  • Miles MV, Horn P, Miles L, Tang P, Steele P, DeGrauw T (2002) Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res 22(8):919–929. doi:10.1016/s0271-5317(02)00402-5

    CAS  Google Scholar 

  • Miles MV, Patterson BJ, Schapiro MB, Hickey FJ, Chalfonte-Evans M, Horn PS, Hotze SL (2006) Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial. Pediatr Neurol 35(1):30–37. doi:10.1016/j.pediatrneurol.2005.11.004

    PubMed  Google Scholar 

  • Miles MV, Patterson BJ, Chalfonte-Evans ML, Horn PS, Hickey FJ, Schapiro MB, Steele PE, Tang PH, Hotze SL (2007) Coenzyme Q10 (Ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatr Neurol 37(6):398–403. doi:10.1016/j.pediatrneurol.2007.08.003

    PubMed  Google Scholar 

  • Mitchell P (1990) The classical mobile carrier function of lipophilic quinones in the osmochemistry of electron-driven proton translocation. In: Lenaz G, Barnabei O, Rabbi A, Battino M (eds) Highlights in ubiquinone research. Taylor and Francis, London, pp 77–82

    Google Scholar 

  • Mohr D, Bowry VW, Stocker R (1992) Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1126(3):247–254

    PubMed  CAS  Google Scholar 

  • Moldenhauer J, Cully J (2005) Method for producing a coenzyme Q10/γ-cyclodextrin complex. United States Patent

  • Molyneux S, Florkowski C, Lever M, George P (2004) The bioavailability of coenzyme Q 10 supplements available in New Zealand differs markedly. N Z Med J 117(1203)

  • Mortensen SA (1993) Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (Ubiquinone). J Mol Med 71(8 Suppl):S116–S123. doi:10.1007/bf00226851

    CAS  Google Scholar 

  • Mortensen SA (2003) Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure. Rationale, design and end-points of “Q-symbio”: A multinational trial. BioFactors 18(1):79–89

    PubMed  CAS  Google Scholar 

  • Mortensen S, Vadhanavikit S, Muratsu K, Folkers K (1990) Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React 12(3):155

    PubMed  CAS  Google Scholar 

  • Mozafari MR, Khosravi-Darani K, Borazan GG, Cui J, Pardakhty A, Yurdugul S (2008) Encapsulation of food ingredients using nanoliposome technology. Int J Food Prep 11(4):833–844

    CAS  Google Scholar 

  • Müller RH, Keck CM (2012) 20 years drug nanocrystals: where are we, and where to go? Eur J Pharm Biopharm 80(1):1–3. doi:10.1016/j.ejpb.2011.09.012

    PubMed  Google Scholar 

  • Müller R, Mäder K, Lippacher A, Jenning V (1999) Fest-flüssig (halbfeste) Lipidpartikel (Nano-Compartiment-Carrier-NCC) und Verfahren zur Herstellung hochkonzentrierter Lipidpartikel/Lipid particles based on matrix comprising solid and liquid lipid, useful in diagnostics and for controlled release of active agents, especially pharmaceuticals. Germany Patent DE19945203A1

  • Nawarskas JJ (2005) HMG-CoA reductase inhibitors and coenzyme Q10. Cardiol Rev 13(2):76–79

    PubMed  Google Scholar 

  • Nazzal S, Guven N, Reddy IK, Khan MA (2002a) Preparation and characterization of coenzyme Q10–Eudragit® Solid dispersion. Drug Dev Ind Pharm 28(1):49–57. doi:10.1081/DDC-120001485

    PubMed  CAS  Google Scholar 

  • Nazzal S, Nutan M, Palamakula a, Shah R, Zaghloul aa, Khan Ma (2002b) Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients. Int J Pharm 240(1–2):103–114

    PubMed  CAS  Google Scholar 

  • Nazzal S, Smalyukh II, Lavrentovich OD, Khan Ma (2002c) Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int J Pharm 235(1–2):247–265

    PubMed  CAS  Google Scholar 

  • Nazzal S, Zaghloul A-A, Khan MA (2002d) Effect of extragranular microcrystalline cellulose on compaction, surface roughness, and in vitro dissolution of a self-nanoemulsified solid dosage form of ubiquinone. Pharm tech 26(4):86–98

    CAS  Google Scholar 

  • Nepal PR, Han H-K, Choi H-K (2010a) Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation. Int J Pharm 383(1–2):147–153. doi:10.1016/j.ijpharm.2009.09.031

    PubMed  CAS  Google Scholar 

  • Nepal PR, Han H-K, Choi H-K (2010b) Preparation and in vitro-in vivo evaluation of Witepsol® H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q10. Eur J Pharm Sci 39(4):224–232. doi:10.1016/j.ejps.2009.12.004

    PubMed  CAS  Google Scholar 

  • Niklowitz P, Menke T, Andler W, Okun JG (2004) Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults. Clin Chim Acta 342(1–2):219–226. doi:10.1016/j.cccn.2003.12.020

    PubMed  CAS  Google Scholar 

  • Nims RM, Vacca JB, Blair DT, Waring PP (1973) Correlation of plasma volume and body weight in dogs. Army Medical Research and Nutrition Lab Denver Colo. http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0776927. Accessed 11 April 2011

  • Nishimura A, Yanagawa H, Fujikawa N, Kiriyama A, Shibata N (2009) Pharmacokinetic profiles of coenzyme Q10: absorption of three different oral formulations in rats. J Health Sci 55(4):540–548

    CAS  Google Scholar 

  • Ochiai A, Itagaki S, Kurokawa T, Kobayashi M, Hirano T, Iseki K (2007) Improvement in intestinal coenzyme Q10 absorption by food intake. Yakugaku Zasshi 127(8):1251–1254. doi:10.1248/yakushi.127.1251

    PubMed  CAS  Google Scholar 

  • Okamoto T, Matsuya T, Fukunaga Y, Kishi T, Yamagami T (1989) Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vitam Nutr Res 59(3):288

    PubMed  CAS  Google Scholar 

  • Okello E, Jiang X, Mohamed S, Zhao Q, Wang T (2009) Combined statin/coenzyme Q10 as adjunctive treatment of chronic heart failure. Med Hypotheses 73(3):306–308. doi:10.1016/j.mehy.2009.03.027

    PubMed  CAS  Google Scholar 

  • Olbrich C, Muller RH (1999) Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures. Int J Pharm 180(1):31–39

    PubMed  CAS  Google Scholar 

  • Olbrich C, Kayser O, Muller RH (2002) Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)-effect of surfactants, storage time and crystallinity. Int J Pharm 237(1–2):119–128

    PubMed  CAS  Google Scholar 

  • Ondarroa M, Sharma SK, Quinn PJ (1986) Solvation properties of ubiquinone-10 in solvents of different polarity. Biosci Rep 6(9):783–796. doi:10.1007/bf01117101

    PubMed  CAS  Google Scholar 

  • Onoue S, Uchida A, Kuriyama K, Nakamura T, Seto Y, Kato M, Hatanaka J, Tanaka T, Miyoshi H, Yamada S (2012) Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors. Eur J Pharm Sci 46(5):492–499. doi:10.1016/j.ejps.2012.03.015

    PubMed  CAS  Google Scholar 

  • Overvad K, Diamant B, Holm L, Holmer G, Mortensen S, Stender S (1999) Coenzyme Q10 in health and disease. Eur J Clin Nutr 53(10):764

    PubMed  CAS  Google Scholar 

  • Ozaki A, Muromachi A, Sumi M, Sakai Y, Morishita K, Okamoto T (2010) Emulsification of coenzyme Q10 using gum arabic increases bioavailability in rats and human and improves Food-processing suitability. J Nutr Sci Vitaminol (Tokyo) 56(1):41–47

    CAS  Google Scholar 

  • Palamakula A (2004) Biopharmaceutical classification and development of limonene-based self-nanoemulsified capsule dosage form of coenzyme Q10. Ph.D. thesis. Texas Texh University, Lubbock

  • Palamakula A, Nutan M, Khan M (2004) Response surface methodology for optimization and characterization of limonene-based coenzyme Q10 self-nanoemulsified capsule dosage form. AAPS PharmSciTech 5(4):114–121. doi:10.1208/pt050466

    Google Scholar 

  • Palamakula A, Soliman M, Khan MMA (2005) Regional permeability of coenzyme Q10 in isolated rat gastrointestinal tracts. Pharmazie 60(3):212–214

    PubMed  CAS  Google Scholar 

  • Pepe S, Marasco SF, Haas SJ, Sheeran FL, Krum H, Rosenfeldt FL (2007) Coenzyme Q10 in cardiovascular disease. Mitochondrion 7(Supplement 1):S154–S167. doi:10.1016/j.mito.2007.02.005

    PubMed  CAS  Google Scholar 

  • Piao H, Ouyang M, Xia D, Quan P, Xiao W, Song Y, Cui F (2011) In vitro—in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals. Int J Pharm 419(1–2):255–259. doi:10.1016/j.ijpharm.2011.07.016

    PubMed  CAS  Google Scholar 

  • Porter CJH, Charman WN (2001) Lipid-based formulations for oral administration: opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs. J Recept Signal Transduct Res 21(2–3):215–257. doi:10.1081/RRS-100107429

    PubMed  CAS  Google Scholar 

  • Pouton CW (1985) Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification. Int J Pharm 27(2–3):335–348. doi:10.1016/0378-5173(85)90081-x

    CAS  Google Scholar 

  • Pouton CW (2000) Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and `self-microemulsifying’ drug delivery systems. Eur J Pharm Sci 11(Supplement 2):S93–S98. doi:10.1016/s0928-0987(00)00167-6

    PubMed  CAS  Google Scholar 

  • Pravst I, Zmitek K, Zmitek J (2010) Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr 50(4):269

    PubMed  CAS  Google Scholar 

  • Probst R, Lim J, Bird D, Pole G, Sato A, Claybaugh J (2006) Gender differences in the blood volume of conscious Sprague-Dawley rats. J Am Assoc Lab Anim Sci 45(2):49

    PubMed  CAS  Google Scholar 

  • Prosek M, Smidovnik A, Fir M, Strazisar M, Golc-Wondra A, Andrensek S, Zmitek J (2005) Water-soluble coenzyme q10 in inclusion complex with beta-cyclodextrin, process of preparing, and use thereof

  • Prosek M, Butinar J, Lukanc B, Fir MM, Milivojevic L, Krizman M, Smidovnik A (2008) Bioavailability of water-soluble CoQ10 in beagle dogs. J Pharm Biomed Anal 47(4–5):918–922. doi:10.1016/j.jpba.2008.04.007

    PubMed  CAS  Google Scholar 

  • Quinzii CM, Hirano M (2010) Coenzyme Q and mitochondrial disease. Dev Disabil Res Rev 16(2):183–188. doi:10.1002/ddrr.108

    PubMed  Google Scholar 

  • Ravichandran R (2009) Nanotechnology-based drug delivery systems. Nanobiotechnol 5(1):17–33. doi:10.1007/s12030-009-9028-2

    CAS  Google Scholar 

  • Reahal S, Wrigglesworth J (1992) Tissue concentrations of coenzyme Q10 in the rat following its oral and intraperitoneal administration. Drug Metab Dispos 20(3):423–427

    PubMed  CAS  Google Scholar 

  • Roffe L, Schmidt K, Ernst E (2004) Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review. J Clin Oncol 22(21):4418–4424. doi:10.1200/jco.2004.02.034

    PubMed  CAS  Google Scholar 

  • Rosenfeldt F, Hilton D, Pepe S, Krum H (2003) Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. BioFactors 18(1–4):91–100. doi:10.1002/biof.5520180211

    PubMed  CAS  Google Scholar 

  • Sakata T, Furuya R, Shimazu T, Odamaki M, Ohkawa S, Kumagai H (2008) Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Blood Purif 26(4):371–378

    PubMed  CAS  Google Scholar 

  • Sarter B (2002) Coenzyme Q10 and cardiovascular disease: a review. J Cardiovasc Nurs 16(4):9–20

    PubMed  Google Scholar 

  • Scalori V, Alessandri M, Giovannini L, Bertelli A (1990) Plasma and tissue concentrations of coenzyme Q10 in the rat after intravenous, oral and topical administrations. Int J Tissue React 12(3):149

    PubMed  CAS  Google Scholar 

  • Schaars CF, Stalenhoef AF (2008) Effects of ubiquinone (coenzyme Q10) on myopathy in statin users. Curr Opin Lipidol 19(6):553–557

    PubMed  CAS  Google Scholar 

  • Schulz C, Obermüller-Jevic UC, Hasselwander O, Bernhardt J, Biesalski HK (2006) Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu™ Q10). Int J Food Sci Nutr 57(7–8):546–555. doi:10.1080/09637480601058320

    PubMed  CAS  Google Scholar 

  • Serebruany VL, Ordonez JV, Herzog WR, Rohde M, Mortensen SA, Folkers K, Gurbel PA (1997) Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. J Cardiovasc Pharmacol 29(1):16–22

    PubMed  CAS  Google Scholar 

  • Shegokar R, Müller RH (2010) Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. Int J Pharm 399(1–2):129–139. doi:10.1016/j.ijpharm.2010.07.044

    PubMed  CAS  Google Scholar 

  • Shults CW (2005) Therapeutic role of coenzyme Q(10) in Parkinson’s disease. Pharmacol Ther 107(1):120–130

    PubMed  CAS  Google Scholar 

  • Shults CW, Haas R (2005) Clinical trials of coenzyme Q10 in neurological disorders. BioFactors 25(1):117–126

    PubMed  CAS  Google Scholar 

  • Shults CW, Flint Beal M, Song D, Fontaine D (2004) Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol 188(2):491–494. doi:10.1016/j.expneurol.2004.05.003

    PubMed  CAS  Google Scholar 

  • Singh R, Niaz M, Rastogi V, Rastogi S (1998) Coenzyme Q in cardiovascular disease. J Assoc Physicians India 46(3):299

    PubMed  CAS  Google Scholar 

  • Singh RB, Niaz MA, Kumar A, Sindberg CD, Moesgaard S, Littarru GP (2005) Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. BioFactors 25(1–4):219–224. doi:10.1002/biof.5520250127

    PubMed  CAS  Google Scholar 

  • Singh U, Devaraj S, Jialal I (2007) Coenzyme Q10 supplementation and heart failure. Nutr Rev 65(6):286–293. doi:10.1111/j.1753-4887.2007.tb00306.x

    PubMed  Google Scholar 

  • Sobreira C, Hirano M, Shanske S, Keller RK, Haller RG, Davidson E, Santorelli FM, Miranda AF, Bonilla E, Mojon DS, Barreira AA, King MP, DiMauro S (1997) Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology 48(5):1238–1243

    PubMed  CAS  Google Scholar 

  • Stamelou M, Reuss A, Pilatus U, Magerkurth J, Niklowitz P, Eggert KM, Krisp A, Menke T, Schade-Brittinger C, Oertel WH, Höglinger GU (2008) Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial. Mov Disord 23(7):942–949. doi:10.1002/mds.22023

    PubMed  Google Scholar 

  • Stocker R, Suarna C (1993) Extrecellular reduction of ubiquinone-1 and-10 by human Hep G2 and blood cells. Biochim Biophys Acta 1158(1):15–22

    PubMed  CAS  Google Scholar 

  • Supersaxo AW, Weder MA, Weder HG (2003) Microemulsion-preconcentrates and microemulsions comprising coenzyme Q10

  • Terao K, Nakata D, Fukumi H, Schmid G, Arima H, Hirayama F, Uekama K (2006) Enhancement of oral bioavailability of coenzyme Q10 by complexation with [γ]-cyclodextrin in healthy adults. Nutr Res 26(10):503–508. doi:10.1016/j.nutres.2006.08.004

    CAS  Google Scholar 

  • Tran MT, Mitchell TM, Kennedy DT, Giles JT (2001) Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy 21(7):797–806. doi:10.1592/phco.21.9.797.34564

    PubMed  CAS  Google Scholar 

  • Ullmann U, Metzner J, Schulz C, Perkins J, Leuenberger B (2005) A new Coenzyme Q10 tablet-grade formulation (all-Q) is bioequivalent to Q-Gel and both have better bioavailability properties than Q-SorB. J Med Food 8(3):397–399

    PubMed  CAS  Google Scholar 

  • Villalba JM, Parrado C, Santos-Gonzalez M, Alcain FJ (2010) Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Expert Opin Investig Drugs 19(4):535–554. doi:10.1517/13543781003727495

    PubMed  CAS  Google Scholar 

  • Wahlqvist ML, Wattanapenpaiboon N, Savige GS, Kannar D (1998) Bioavailability of two different formulations of coenzyme Q 10 in healthy subjects. Asia Pac J Clin Nutr 7(1):37–40

    CAS  Google Scholar 

  • Wajda R (2006) emulsive water-soluble concentrates. United States Patent

  • Wajda R, Zirkel J, Schaffer T (2007) Increase of bioavailability of coenzyme Q(10) and vitamin E. J Med Food 10(4):731–734

    PubMed  CAS  Google Scholar 

  • Watson PS, Scalia GM, Galbraith A, Burstow DJ, Bett N, Aroney CN (1999) Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 33(6):1549–1552

    PubMed  CAS  Google Scholar 

  • Weant KA, Smith KM (2005) The role of coenzyme Q10 in heart failure. Ann Pharmacother 39(9):1522–1526. doi:10.1345/aph.1E554

    PubMed  CAS  Google Scholar 

  • Weber C, Sejersgård J, Mortensen S, Paulsen G, Hølmer G (1994) Antioxidative effect of dietary coenzyme Q10 in human blood plasma. Int J Vitam Nutr Res 64(4):311

    PubMed  CAS  Google Scholar 

  • Weber C, Bysted A, Hølmer G (1997) Intestinal absorption of coenzyme Q10 administered in a meal or as capsules to healthy subjects. Nutr Res 17(6):941–945. doi:10.1016/s0271-5317(97)00059-6

    CAS  Google Scholar 

  • Weis M, Mortensen SA, Rassing MR, Møller-Sonnergaard J, Poulsen G, Rasmussen SN (1994) Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol Aspects Med 15(Suppl):s273–s280

    PubMed  CAS  Google Scholar 

  • Wyman M, Leonard M, Morledge T (2010) Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? Cleve Clin J Med 77(7):435–442. doi:10.3949/ccjm.77a.09078

    PubMed  Google Scholar 

  • Xia S, Xu S, Zhang X (2006) Optimization in the preparation of coenzyme Q10 nanoliposomes. J Agric Food Chem 54(17):6358–6366. doi:10.1021/jf060405o

    PubMed  CAS  Google Scholar 

  • Xia S, Xu S, Zhang X, Zhong F (2007) Effect of Coenzyme Q10 incorporation on the characteristics of nanoliposomes. J Phys Chem B 111(9):2200–2207. doi:10.1021/jp066130x

    PubMed  CAS  Google Scholar 

  • Young AJ, Johnson S, Steffens DC, Doraiswamy PM (2007) Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr 12(1):62–68

    PubMed  Google Scholar 

  • Zaghloul A, Gurley B, Khan M, Bhagavan H, Chopra R, Reddy I (2002) Bioavailability assessment of oral coenzyme Q10 formulations in dogs. Drug Dev Ind Pharm 28(10):1195–1200. doi:10.1081/DDC-120015352

    PubMed  CAS  Google Scholar 

  • Zhang Y, Åberg F, Appelkvist E-L, Dallner G, Ernster L (1995) Uptake of dietary coenzyme Q supplement is limited in rats. J Nutr 125(3):446–453

    PubMed  CAS  Google Scholar 

  • Zita Č, Overvad K, Mortensen SA, Sindberg CD, Moesgaard S, Hunter DA (2003) Serum coenzyme Q10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q10 for two months in a randomised controlled study. BioFactors 18(1–4):185–193. doi:10.1002/biof.5520180221

    PubMed  CAS  Google Scholar 

  • Žmitek J, Šmidovnik A, Fir M, Prošek M, Žmitek K, Walczak J, Pravst I (2008) Relative bioavailability of two forms of a novel water-soluble coenzyme Q10. Ann Nutr Metab 52(4):281–287

    PubMed  Google Scholar 

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  1. Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Institute of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169, Berlin, Germany

    Abdulwahab Barakat, Ranjita Shegokar, Michael Dittgen & Rainer H. Müller

  2. PharmaSol GmbH, Blohmstr. 66A, 12307, Berlin, Germany

    Ranjita Shegokar

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  1. Abdulwahab Barakat
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  2. Ranjita Shegokar
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  3. Michael Dittgen
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  4. Rainer H. Müller
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Correspondence to Michael Dittgen or Rainer H. Müller.

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Barakat, A., Shegokar, R., Dittgen, M. et al. Coenzyme Q10 oral bioavailability: effect of formulation type. Journal of Pharmaceutical Investigation 43, 431–451 (2013). https://doi.org/10.1007/s40005-013-0101-4

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