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Fabrication and evaluation of growth factor-immobilized injectable microspheres for the soft tissue augmentation

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Growth factor [basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF)]-immobilized polycaprolactone (PCL)/Pluronic F127 microspheres were fabricated to investigate their potential use as an injectable bioactive filler for enhancing soft tissue augmentation. It was expected that the microspheres may stimulate the regeneration of soft tissues by the sustained release of the growth factors as well as provide a bulking effect by the injected volume of the microspheres, and thus allow more effective long-term filling effect. The PCL/F127 microspheres were fabricated by an isolated particle-melting method, and the growth factors were easily immobilized onto the surfaces of the PCL/F127 microspheres via heparin binding. From an in vivo animal study, it was observed that the mixture of both bFGF-immobilized and EGF-immobilized microspheres lead to effective soft tissue augmentation.

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Authors and Affiliations

  1. Department of Advanced Materials, Hannam University, Daejeon, 305-811, Korea

    Jun Goo Kang, Tae Ho Kim & Jin Ho Lee

  2. Department of Nanobiomedical Science, Dankook University, Cheonan, 330-714, Korea

    Se Heang Oh

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  1. Jun Goo Kang
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  2. Tae Ho Kim
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  3. Se Heang Oh
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  4. Jin Ho Lee
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Correspondence to Jin Ho Lee.

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Kang, J.G., Kim, T.H., Oh, S.H. et al. Fabrication and evaluation of growth factor-immobilized injectable microspheres for the soft tissue augmentation. Tissue Eng Regen Med 11 (Suppl 1), 8–15 (2014). https://doi.org/10.1007/s13770-013-1126-5

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  • DOI: https://doi.org/10.1007/s13770-013-1126-5

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