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Polymer-functionalized carbon nanotubes in cancer therapy: a review

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Abstract

The increasing importance of nanotechnology in the field of biomedical applications has encouraged the development of new nanomaterials endowed with multiple functions. Novel nanoscale drug delivery systems with diagnostic, imaging and therapeutic properties hold many promises for the treatment of different types of diseases, including cancer, infection and neurodegenerative syndromes. Carbon nanotubes (CNTs) are both low-dimensional sp2 carbon nanomaterials exhibiting many unique physical and chemical properties that are interesting in a wide range of areas including nanomedicine. Since 2004, CNTs have been extensively explored as drug delivery carriers for the intracellular transport of chemotherapy drugs, proteins and genes. In vivo cancer treatment with CNTs has been demonstrated in animal experiments by several different groups. Herein, the recent works on anticancer drug delivery systems based on carbon nanotubes are reviewed and some of more specific and important novel drug delivery devices are discussed in detail. This paper focuses on modifications of CNTs by polymers through covalent and non-covalent attachments: two different methods as critical steps in preparation of anticancer drug delivery systems from CNTs. In this respect the in vivo and in vitro behaviors and toxicity of the CNTs modified by polymers are summarized as well. Well-functionalized CNTs did not show any significant toxicity after injection into mice. Moreover, administration and excretion of CNT-based nanocarriers are discussed. It was concluded that future development of CNT-based nanocarriers may bring novel opportunities to cancer diagnosis and therapy.

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  1. Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran

    Mohammad Eskandari, Seyed Hassan Hosseini, Mohsen Adeli & Ali Pourjavadi

  2. Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran

    Mohsen Adeli

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  1. Mohammad Eskandari
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  2. Seyed Hassan Hosseini
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Correspondence to Mohsen Adeli.

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Eskandari, M., Hosseini, S.H., Adeli, M. et al. Polymer-functionalized carbon nanotubes in cancer therapy: a review. Iran Polym J 23, 387–403 (2014). https://doi.org/10.1007/s13726-014-0228-9

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