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Central depressant activity of ethanol extract of Nymphaea alba rhizome in mice

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Abstract

Ethanol extract of the of rhizome of Nymphaea alba, at graded doses was investigated for the central depressant activity of the ethanol extract of rhizome. The behavioral effect of the extract (75, 150 and 300 mg/kg) was evaluated using diazepam induced sleep test, hole-board test, beam walking assay, staircase test, open field test and elevated plus maze assay, all in mice. The findings of this study suggest that the extract of N. alba rhizome contains some bioactive principles that are sedative in nature.

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Authors and Affiliations

  1. Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur, 713 206, India

    Anindya Bose & Sarbani Dey Ray

  2. Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, 754202, India

    Moumita Sahoo

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  1. Anindya Bose
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  2. Sarbani Dey Ray
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  3. Moumita Sahoo
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Correspondence to Anindya Bose.

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Bose, A., Ray, S.D. & Sahoo, M. Central depressant activity of ethanol extract of Nymphaea alba rhizome in mice. Orient Pharm Exp Med 13, 159–164 (2013). https://doi.org/10.1007/s13596-013-0108-4

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  • DOI: https://doi.org/10.1007/s13596-013-0108-4

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