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Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene]

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Abstract

The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., \( w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. \) The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good.

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Acknowledgements

Authors are grateful to the Higher Education Commission (HEC) for financial assistance of this project. Authors are also grateful to Dr Zafar Iqbal Zafar and Dr Anees for mathematical modeling and Dr Yar Muhammad, IRCBM COMSATS, Lahore, Pakistan, for their support regarding the project.

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Authors and Affiliations

  1. Department of Basic Sciences and Humanities, University of Engineering and Technology Lahore, Narowal Campus, Lahore, Pakistan

    Abid M. Amin & Habib Hussain

  2. Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

    Abid M. Amin

  3. Institute of Chemistry, University of the Punjab, Lahore, Pakistan

    Azeem Intisar

  4. Department of Basic Sciences and Humanities, University of Engineering and Technology Lahore, KSK Campus, Lahore, Pakistan

    Zulfiqar Ali

  5. Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

    Asma Naz

  6. Department of Chemistry, Lahore Garrison University, Lahore, Pakistan

    Shabbir Hussain, Tanzeela G. Shahzady & Muhammad Waqas

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Correspondence to Abid M. Amin.

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Amin, A.M., Intisar, A., Hussain, H. et al. Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene]. Arab J Sci Eng 45, 241–247 (2020). https://doi.org/10.1007/s13369-019-04278-8

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