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Engineering solid lipid nanoparticles for improved drug delivery: promises and challenges of translational research

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Abstract

Nanotechnology is expected to revolutionize existing drug delivery. Many nanostructured systems have been employed for drug delivery and yielded some promising results. Solid lipid nanoparticles (SLN) have been looked at as a potential drug carrier system since last two decades. SLN do not show biotoxicity as they are prepared from physiological lipids. SLN are especially useful in drug delivery as they can enhance the absorption of drugs and improves the bioavailability of both hydrophilic and lipophilic drugs. This paper presents an overview about the various classes of SLN, comparison with available drug carrier systems, different ways of production, in vivo fate and biodistribution and various applications of SLN. Besides, aspects of stability, hurdles and strategies for SLN manufacturing with potential of clinical translation are also discussed.

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Abbreviations

NDDS:

Novel drug delivery system

SLN:

Solid lipid nanoparticles

DDS:

Drug delivery system

NLC:

Nanostructured lipid carriers

SCF:

Supercritical fluid technology

SFEE:

Supercritical fluid extraction of emulsions

GAMA:

Gas-assisted melting atomisation

O/W:

Oil-in-water

CM:

Mixing chamber

TEM:

Transmission electron microscopy

SEM:

Scanning electron microscopy

PCM:

Phase contrast optical microscopy

AFM:

Atomic force microscopy

PCS:

Photon correlation spectroscopy

SAX:

Synchrotron radiation X-ray

GPC:

Gel permeation chromatography

SWCNT:

Single-walled carbon nanotubes

TMS:

Thermosensitive magneto liposomes

MTX:

Methotrexate

MBC:

Metastatic breast cancer

PNET:

Phase nanoparticle engineering technology

cSLN:

Cationic solid lipid nanoparticles

PTX:

Paclitaxel

ADA:

Adenosine deaminase

DNA:

Deoxyribonucleic acid

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Authors and Affiliations

  1. SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur, India

    Dinesh Kumar Mishra

  2. Truba Institute of Pharmacy, Bhopal, India

    Vinod Dhote

  3. Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, India

    Punit Bhatnagar

  4. Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India

    Pradyumna Kumar Mishra

  5. Department of Pharmaceutics, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur, CG, 495009, India

    Dinesh Kumar Mishra

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  1. Dinesh Kumar Mishra
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  4. Pradyumna Kumar Mishra
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Correspondence to Dinesh Kumar Mishra.

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Mishra, D.K., Dhote, V., Bhatnagar, P. et al. Engineering solid lipid nanoparticles for improved drug delivery: promises and challenges of translational research. Drug Deliv. and Transl. Res. 2, 238–253 (2012). https://doi.org/10.1007/s13346-012-0088-9

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