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Comparison of meta-analyses among elastosonography (ES) and positron emission tomography/computed tomography (PET/CT) imaging techniques in the application of prostate cancer diagnosis

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Tumor Biology

Abstract

The early diagnosis of prostate cancer (PCa) appears to be of vital significance for the provision of appropriate treatment programs. Even though several sophisticated imaging techniques such as positron emission tomography/computed tomography (PET/CT) and elastosonography (ES) have already been developed for PCa diagnosis, the diagnostic accuracy of these imaging techniques is still controversial to some extent. Therefore, a comprehensive meta-analysis in this study was performed to compare the accuracy of various diagnostic imaging methods for PCa, including 11C-choline PET/CT, 11C-acetate PET/CT, 18F-fluorocholine PET/CT, 18F-fluoroglucose PET/CT, transrectal real-time elastosonography (TRTE), and shear-wave elastosonography (SWE). The eligible studies were identified through systematical searching for the literature in electronic databases including PubMed, Cochrane, and Web of Science. On the basis of the fixed-effects model, the pooled sensitivity (SEN), specificity (SPE), and area under the receiver operating characteristics curve (AUC) were calculated to estimate the diagnostic accuracy of 11C-choline PET/CT, 11C-acetate PET/CT, 18F-fluorocholine (FCH) PET/CT, 18F-fluoroglucose (FDG) PET/CT, TRTE, and SWE. All the statistical analyses were conducted with R language Software. The present meta-analysis incorporating a total of 82 studies demonstrated that the pooled sensitivity of the six imaging techniques were sorted as follows: SWE > 18F-FCH PET/CT > 11C-choline PET/CT > TRTE > 11C-acetate PET/CT > 18F-FDG PET/CT; the pooled specificity were also compared: SWE > 18F-FCH PET/CT > 11C-choline PET/CT > TRTE > 18F-FDG PET/CT > 11C-acetate PET/CT; finally, the pooled diagnostic accuracy of the six imaging techniques based on AUC were ranked as below: SWE > 18F-FCH PET/CT > 11C-choline PET/CT > TRTE > 11C-acetate PET/CT > 18F-FDG PET/CT. SWE and 18F-FCH PET/CT imaging could offer more assistance in the early diagnosis of PCa than any other studied imaging techniques. However, the diagnostic ranking of the six imaging techniques might not be applicable to the clinical phase due to the shortage of stratified analysis.

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Acknowledgments

We acknowledge our colleagues for their helpful comments on this paper.

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Authors and Affiliations

  1. Department of Nuclear Medicine, The First Affiliated Hospital of Chinese PLA General Hospital, No. 51 Fucheng Road, Beijing, 100048, China

    Qiaohong Ouyang, Zhongxiang Duan, Jixiao Lei & Guangli Jiao

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  1. Qiaohong Ouyang
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  2. Zhongxiang Duan
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  3. Jixiao Lei
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Correspondence to Qiaohong Ouyang.

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Fig. S1

Summary of forest plots with sensitivities and specificities for 11C-choline PET/CT and 18F-fluorocholine PET/CT in the application of PCa diagnosis (JPEG 136 kb)

High resolution image (EPS 1947 kb)

Fig. S2

SROC curve for diagnosis of PCa patients with 11C-choline PET/CT and 18F-fluorocholine PET/CT (JPEG 64 kb)

High resolution image (EPS 1407 kb)

Fig. S3

Summary of forest plots with sensitivities and specificities for 11C-acetate PET/CT in the application of PCa diagnosis and its SROC curve (JPEG 66 kb)

High resolution image (EPS 1409 kb)

Fig. S4

Summary of forest plots with sensitivities and specificities for 18F-fluoroglucose PET/CT in the application of PCa diagnosis and its SROC curve (JPEG 64 kb)

High resolution image (EPS 1414 kb)

Fig. S5

Summary of forest plots with sensitivities and specificities for shear-wave elastography in the application of PCa diagnosis and its SROC curve (JPEG 61 kb)

High resolution image (EPS 1377 kb)

Fig. S6

Summary of forest plots with sensitivities and specificities for transrectal real-time elastosonography in the application of PCa diagnosis (JPEG 82 kb)

High resolution image (EPS 1548 kb)

Fig. S7

SROC curve for diagnosis of PCa patients with transrectal real-time elastosonography (JPEG 52 kb)

High resolution image (EPS 1297 kb)

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Ouyang, Q., Duan, Z., Lei, J. et al. Comparison of meta-analyses among elastosonography (ES) and positron emission tomography/computed tomography (PET/CT) imaging techniques in the application of prostate cancer diagnosis. Tumor Biol. 37, 2999–3007 (2016). https://doi.org/10.1007/s13277-015-4113-8

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