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Meta-analysis of the relation between vitamin D receptor gene BsmI polymorphism and susceptibility to ovarian cancer

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Tumor Biology

Abstract

The role of vitamin D receptor (VDR) BsmI polymorphism in ovarian cancer development has been studied in various populations, but those results are discordant controversial and ambiguous. Thus, we performed a meta-analysis to assess the association between VDR BsmI polymorphism and susceptibility to ovarian cancer more precisely. Odds ratio (OR) and its 95 % confidence interval (95 % CI) were used for statistical analysis. Nine individual studies with a total 2,331 cases and 3,301 controls were included into this meta-analysis. There was no heterogeneity among those nine studies. Meta-analysis of total nine studies suggested that there was no association between VDR BsmI polymorphism and susceptibility to ovarian cancer (B vs. b, OR = 1.02, 95 % CI = 0.94–1.10, P = 0.616, I 2 = 0 %; BB vs. bb, OR = 1.02, 95 % CI = 0.87–1.20, P = 0.810, I 2 = 0 %; BB/Bb vs. bb, OR = 1.05, 95 % CI = 0.94–1.18, P = 0.391, I 2 = 0 %; BB vs. bb/Bb, OR = 0.99, 95 % CI = 0.85–1.14, P = 0.853, I 2 = 0 %). Meta-analysis of seven studies from Caucasians also showed that there was no association between VDR BsmI polymorphism and susceptibility to ovarian cancer. This meta-analysis suggests that there is no association between VDR BsmI polymorphism and susceptibility to ovarian cancer in Caucasians. Future studies from Asians or Africans are needed to further assess the above association.

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Authors and Affiliations

  1. Department of Gynecology, Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China

    Yan Zhang, Sheng-Chun Tong, Li-Hua Guan, Fei Na, Wei Zhao & Li Wei

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  1. Yan Zhang
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  2. Sheng-Chun Tong
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  3. Li-Hua Guan
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  4. Fei Na
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  5. Wei Zhao
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  6. Li Wei
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Correspondence to Li Wei.

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Zhang, Y., Tong, SC., Guan, LH. et al. Meta-analysis of the relation between vitamin D receptor gene BsmI polymorphism and susceptibility to ovarian cancer. Tumor Biol. 34, 3317–3321 (2013). https://doi.org/10.1007/s13277-013-0900-2

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  • DOI: https://doi.org/10.1007/s13277-013-0900-2

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