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Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer

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Tumor Biology

Abstract

We investigated the association between peroxiredoxin III (PRX III) and chemotherapy resistance in ovarian cancer. Patient’s specimens were taken at the time of surgery. Determination of resistance is based on whether first diagnosis of relapse occurred within 6 months after the cessation of chemotherapy. PRX III expression was immunohistochemically determined in paraffin-embedded specimens from platinum-resistant (Pt-resistant) and platinum-sensitive (Pt-sensitive) patients. The Pt-resistant group had significantly higher PRX III protein compared to the Pt-sensitive group. The two groups showed no significant differences in pathological classification and age, although they differed significantly in tissue differentiation and stage. PRX III protein was significantly higher in the Pt-resistant serous carcinomas, in moderately and poorly differentiated, and in stage III and IV ovarian cancer tissues compared to the Pt-sensitive group. PRX III may be associated with drug resistance in ovarian cancer.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004, China

    Xin-yan Wang & Xiu-qin Li

  2. Department of Gynecology and Obstetrics, Benxi Center Hospital of China Medical University, No. 29 Shengli Road, Benxi, Liaoning, 117000, China

    Hai-jiao Wang

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  1. Xin-yan Wang
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Correspondence to Xiu-qin Li.

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Wang, Xy., Wang, Hj. & Li, Xq. Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer. Tumor Biol. 34, 2275–2281 (2013). https://doi.org/10.1007/s13277-013-0769-0

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  • DOI: https://doi.org/10.1007/s13277-013-0769-0

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