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Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy

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Abstract

Blue light emitting diode (BLED) were known to inhibit cancer proliferation and induced apoptotic cell death by increasing intracellular reactive oxygen species (ROS) and caspase activation. However, not many attempts were made to study the naturally occurring photosensitizer molecule (PS) curcuminoids (CUR) mediated blue light emitting diode induced photodynamic therapy (BLED-PDT). Here, we demonstrated the use of pluronic F127 nanoplatform as a novel BLED-PDT based system for anticancer therapy. Aqueous soluble F127-CUR was proven to significantly mediate BLED-PDT, we anticipate that F127-CUR combined with BLED to induce BLED-PDT could be a promising cancer treatment modality.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea

    Berwin Singh Swami Vetha, Eun-Mi Kim, Phil-Sun Oh, Seok Tae Lim, Myung-Hee Sohn & Hwan-Jeong Jeong

  2. Department of Physiology, Research Institute for Endocrine Sciences, Chonbuk National University Hospital, Jeonju, Korea

    Suhn Hee Kim

Authors
  1. Berwin Singh Swami Vetha
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  2. Eun-Mi Kim
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  3. Phil-Sun Oh
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  4. Suhn Hee Kim
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  5. Seok Tae Lim
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  6. Myung-Hee Sohn
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  7. Hwan-Jeong Jeong
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Correspondence to Hwan-Jeong Jeong.

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Acknowledgment: This work was supported by Brain Korea 21+ project in 2018. This work was also supported by Radiation Technology R&D program 2016M2A2A7A03912640 through the National Research Foundation of Korea funded by the Ministry of Science ICT & Future Planning and from the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Korea (grant number: HI18C0139). The authors are thankful to CURF, Chonbuk National University, South Korea for TEM analysis.

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Vetha, B.S.S., Kim, EM., Oh, PS. et al. Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy. Macromol. Res. 27, 1179–1184 (2019). https://doi.org/10.1007/s13233-019-7168-3

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  • DOI: https://doi.org/10.1007/s13233-019-7168-3

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