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Gold half-shell coated hyaluronic acid-doxorubicin conjugate micelles for theranostic applications

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Abstract

Theranostic systems have been widely investigated for application in the diagnostic therapy of cancers. In this work, hyaluronic acid (HA)-doxorubicin (DOX) conjugate was successfully synthesized by the amide bond formation between amine groups of DOX and carboxylic groups of HA activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysulfosuccinimide. The 1H nuclear magnetic resonance (NMR) and gel permeation chromatographic (GPC) analyses confirmed the successful synthesis of HA-DOX conjugates. HA-DOX conjugates self-assembled to micelle-like nanoparticles in aqueous solution. In vitro anti-proliferation tests of cancer cells confirmed the anti-tumor effect of HA-DOX conjugate micelles. For further application, the micelles were coated with a gold (Au) half-shell by the thermal vapor deposition method, which might contribute to prolonging the residence time in the body with a versatile surface modification on the Au surface. TEM analysis confirmed the successful Au coating on HA-DOX conjugate micelles with a thickness of 15 nm. The Au half-shell-coated HADOX conjugate micelles might be successfully exploited for cancer theranostic applications such as chemotherapy, hyperthermia, and bioimaging.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Pohang University of Science and Technology, Gyeongbuk, 790-784, Korea

    Ki Su Kim, Sang-Jun Park, Min-Young Lee, Kyung-Geun Lim & Sei Kwang Hahn

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  1. Ki Su Kim
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  2. Sang-Jun Park
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  3. Min-Young Lee
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  4. Kyung-Geun Lim
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  5. Sei Kwang Hahn
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Correspondence to Sei Kwang Hahn.

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The authors equally contributed to this work.

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Kim, K.S., Park, SJ., Lee, MY. et al. Gold half-shell coated hyaluronic acid-doxorubicin conjugate micelles for theranostic applications. Macromol. Res. 20, 277–282 (2012). https://doi.org/10.1007/s13233-012-0062-x

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  • DOI: https://doi.org/10.1007/s13233-012-0062-x

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