Abstract
Nanodiamonds (NDs) have emerged as a very useful material for drug-carrier applications in nanomedicine. Herein, we prepared cisplatin-like structures on the surface of the NDs to investigate their potential use as anticancer drugs. Cis-diamminediiodoplatinum(II)-modified NDs have been prepared by the coordination of [PtI4]2− to amine-modified NDs. Subsequent halogen exchange of the iodine ligands with chloride ions resulted in the formation of cis-diamminedichloroplatinum(II)-modified NDs, 100% exchange occurred as detected by XPS analysis. Another cisplatin-like ND derivative has been constructed, where the platinum is anchored onto the NDs via an amine-capped silane linker. This was achieved by grafting (3-aminopropyl)trimethoxysilane (APTMES) onto the NDs, followed by coordination of the [PtI4]2− Pt-precursor and halogen exchange with Cl− to produce cis-diamminedichlorodoplatinum(II)-silane-modified NDs. Since the Pt is three methylene groups away from the ND support, it is more flexible to move and participate in reactions than the platinum of the cis-diamminedichloroplatinum(II)-modified NDs, which results in its improved IC50 value of 2.6 µml against HeLa cancer cells vs. the 6.5 µml of diamminedichloroplatinum(II)-modified NDs.
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Acknowledgements
The author would like to acknowledge generous financial support from the National Nanoscience Postgraduate Teaching and Training Platform, Sasol, the NRF and UFS during this study.
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Fiekkies, J.T.R., Fourie, E. & Erasmus, E. Cisplatin-functionalized nanodiamonds: preparation and characterization, with potential antineoplastic application. Appl Nanosci 11, 2235–2245 (2021). https://doi.org/10.1007/s13204-021-01955-9
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DOI: https://doi.org/10.1007/s13204-021-01955-9