Abstract
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.
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Funding
JMND was supported by the Knut and Alice Wallenberg Foundation, the Swedish Research Council (Strategic Research Area EXODIAB, grant 2009-1039), and the Swedish Foundation for Strategic Research (grant IRC15-0067). GCF and PFS were supported by the Brazilian National Council for Scientific and Technological Development (CNPq). GCF was also supported by FAPERJ.
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Belenguer, P., Duarte, J.M.N., Schuck, P.F. et al. Mitochondria and the Brain: Bioenergetics and Beyond. Neurotox Res 36, 219–238 (2019). https://doi.org/10.1007/s12640-019-00061-7
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DOI: https://doi.org/10.1007/s12640-019-00061-7