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Anti-Helicobacter pylori xanthones of Garcinia fusca

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Abstract

A new geranylated xanthone derivative, fuscaxanthone I (1), along with nine xanthones (29 and 11), a biphenyl (10) and three biflavonoids (1214) were isolated from the roots of Garcinia fusca Pierre. Compounds 8, 10 and 1114 were reported from this plant species for the first time. Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and MS. The isolated compounds were evaluated for antibacterial activity against Helicobacter pylori. Cowaxanthone (5) and fukugiside (14) exhibited stronger inhibitory activity against H. pylori DMST reference strain at MICs 4.6 and 10.8 μM, respectively, than that of the control metronidazole. Isojacareubin (8) displayed the most potent activity against H. pylori HP40 clinical isolate with MIC 23.9 μM, which was approximately two times greater than that of the standard drug amoxicillin.

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Acknowledgments

This work was supported by the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission and Srinakharinwirot University (Grant number 231/2554). Authors thank Mr. Maurice Broughton, Chulabhorn Research Institute, Thailand, for proof reading the article.

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Correspondence to Sunit Suksamrarn.

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Nontakham, J., Charoenram, N., Upamai, W. et al. Anti-Helicobacter pylori xanthones of Garcinia fusca . Arch. Pharm. Res. 37, 972–977 (2014). https://doi.org/10.1007/s12272-013-0266-4

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