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Enhanced dissolution of celecoxib by supersaturating self-emulsifying drug delivery system (S-SEDDS) formulation

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Abstract

A supersaturating self-emulsifying drug delivery system (S-SEDDS) was prepared and evaluated for enhanced dissolution of celecoxib (CXB), a poorly water-soluble drug. The selected CXB-dissolved SEDDS formulation consisting 10 % Capryol 90 (oil), 45 % Tween 20 (surfactant), and 45 % Tetraglycol (cosurfactant) had the characteristics of small droplet size and great solubility as 208 nm and 556.7 mg/mL in average, respectively. CXB dissolution from SEDDS in simulated gastric fluid was increased to about 20 % for the initial period of 5 min, but decreased to a half level as time elapsed. Thus, precipitation inhibitors were screened to stabilize the supersaturation. The stabilizing effect of Soluplus, an amphiphilic copolymer, was concentration-dependent, revealing the greatest dissolution of approximately 90 % level with delayed drug crystallization by the addition of the copolymer. CXB dissolution from S-SEDDS was pH-independent. We concluded that S-SEDDS formulation would be very useful in the future for developing oral delivery product of poorly water-soluble drugs.

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Acknowledgments

This research was supported by the Chung-Ang University Research Scholarship Grants in 2012.

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong, Dongjak-gu, Seoul, 156-756, South Korea

    Woo Heon Song, Jong Hyeok Park, Dong Woo Yeom, Byeong Kil Ahn, Kyung Min Lee, Sang Gon Lee, Hye Seung Woo & Young Wook Choi

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  1. Woo Heon Song
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  2. Jong Hyeok Park
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  3. Dong Woo Yeom
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  4. Byeong Kil Ahn
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  5. Kyung Min Lee
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  6. Sang Gon Lee
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  7. Hye Seung Woo
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  8. Young Wook Choi
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Correspondence to Young Wook Choi.

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Woo Heon Song and Jong Hyeok Park contributed equally to this work.

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Song, W.H., Park, J.H., Yeom, D.W. et al. Enhanced dissolution of celecoxib by supersaturating self-emulsifying drug delivery system (S-SEDDS) formulation. Arch. Pharm. Res. 36, 69–78 (2013). https://doi.org/10.1007/s12272-013-0011-z

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