Abstract
Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1′-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC50 values; 13, 12, 11, and 10 µM, respectively) and HepG2 cell lines (IC50 values; 16, 11, 12, and 11 µM, respectively).
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Yeun-Kyung Lee and Chang-Seob Seo contribated equally to this work.
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Lee, YK., Seo, CS., Lee, CS. et al. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis . Arch. Pharm. Res. 32, 1409–1415 (2009). https://doi.org/10.1007/s12272-009-2010-7
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DOI: https://doi.org/10.1007/s12272-009-2010-7