Abstract
Bile duct injuries (BDIs) are fearsome complication following open or laparoscopic cholecystectomy (LC). Significant morbidity can accompany such injuries. Late complications such as anastomotic bile duct strictures or secondary biliary cirrhosis may result in lifelong disability. The aim of the study was to assess the outcome of early (up to 7 days) and delayed (after 6 weeks) definitive repair of BDIs. It was a prospective study from June 2015 to May 2017 done at a tertiary care centre. The patients who underwent surgical management of bile duct injuries were part of the study and were followed up until end of the study period and assessed for stricture as primary objective and other secondary objectives, e.g. post-op complications and grade of repair of bile duct injury. Stricture was defined as stricture causing sign and symptoms requiring surgical, percutaneous or endoscopic intervention. A total of 50 patients were part of the study, out of which 15 underwent early and 35 underwent delayed repair. Mean follow-up of patients was 10.8 months (1–24 months). Bile duct injuries were classified as per Strasberg classification. It included 7 patients with E1, 15 patients of E2, 20 patients of E3, 5 E4 and 3 patients with type D injuries. The surgical reconstruction done was hepaticojejunostomy (HJ) in 48 and primary repair in 2 patients. The post-op complication observed were post-op bile leak in 4 patients (3 in early and 1 in delayed group, p = 0.041) and cholangitis in 3 patients (1 in early group and 2 in delayed group, p = 0.897). On comparison of stricture rate with post-op bile leak and cholangitis, both variables had significantly high stricture rate (p = 0.014 and p = 0.002, respectively). The grades of repair as per Mc Donald’s grading was grade A in 30, B in 16, C in 1 and D in 3 patients. The stricture was seen in 2 patients of early group and 1 patient in delayed group (p = 0.153). Our result suggests that early repair has more post-op complication with comparable stricture rates in patients with no evidence of systemic sepsis and intra-abdominal collection. Such repairs should be done at specialized centres with surgeons having experience in managing these cases.
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References
Mangieri CW, Hendren BP, Strode MA, Bandera BC, Faler BJ (2019) Bile duct injuries (BDI) in the advanced laparoscopic cholecystectomy era. Surg Endosc 33:724–730
Strasberg SM, Hertl M, Soper NJ (1995) An analysis of the problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg 180:101–125
Carroll BJ, Birth M, Phillips EH (1998) Common bile duct injuries during laparoscopic cholecystectomy that result in litigation. Surg Endosc 12:310–314
de Reuver PR, Grossmann I, Busch OR, Obertop H, van Gulik TM, Gouma DJ (2007) Referral pattern and timing of repair are risk factors for complications after reconstructive surgery for bile duct injury. Ann Surg 245:763–770
Thomson BN, Parks RW, Madhavan KK, Wigmore SJ, Garden OJ (2006) Early specialist repair of biliary injury. Br J Surg 93:216–220
Stewart L, Way LW (2009) Laparoscopic bile duct injuries: timing of surgical repair does not influence success rate. A multivariate analysis of factors influencing surgical outcomes. HPB 11:516–522
McDonald ML, Farnell MB, Nagorney DM, Ilstrup DM, Kutch JM (1995) Benign biliary strictures: repair and outcome with a contemporary approach. Surgery 118:582–591
Sahajpal AK, Chow SC, Dixon E, Greig PD, Gallinger S, Wei AC (2010) Bile duct injuries associated with laparoscopic cholecystectomy: timing of repair and long-term outcomes. Arch Surg 145:757–763
Iannelli A, Paineau J, Hamy A, Schneck AS, Schaaf C, Gugenheim J (2013) Primary versus delayed repair for bile duct injuries sustained during cholecystectomy: results of a survey of the Association Francaise de Chirurgie. HPB 15:611–616
Dominguez-Rosado I, Sanford DE, Liu J, Hawkins WG, Mercado MA (2016) Timing of surgical repair after bile duct injury impacts postoperative complications but not anastomotic patency. Ann Surg 264:544–553
Aziz AM, Shoreem H, Sallam A, Al-warraky M, Sadek A, Osman M (2016) Iatrogenic bile duct injury: a retrospective analysis of short- and long-term outcomes after surgical repair. Saudi Surg J 4:61–69
Wang X, Yu WL, Fu XH, Zhu B, Zhao T, Zhang YJ (2020) Early versus delayed surgical repair and referral for patients with bile duct injury: a systematic review and meta-analysis. Ann Surg 271:449–459
Felekouras E, Petrou A, Neofytou K, Moris D, Dimitrokallis N, Bramis K et al (2015) Early or delayed intervention for bile duct injuries following laparoscopic cholecystectomy? A dilemma looking for an answer. Gastroenterol Res Pract:104235. https://doi.org/10.1155/2015/104235
Hajjar NA, Tomus C, Mocan L, Mocan T, Graur F, Iancu C et al (2014) Management of bile duct injuries following laparoscopic cholecystectomy: long-term outcome and risk factors infuencing biliary reconstruction. Chirurgia 109:493–499
Sultan AM, Elshobary MM, Askar W, El Nakeeb A, Abdelrafee A, Atef E et al (2019) Risk factors and predictors of poor outcome following hepaticojejunostomy for postcholecystecomy bile duct injury. Indian J Surg 81:557–563
Hall JG, Pappas TN (2004) Current management of biliary strictures. J Gastrointest Surg 8:1098–1110
Lillemoe KD, Martin SA, Cameron JL, Yeo CJ, Talamini MA, Kaushal S (1997) Major bile duct injuries during laparoscopic cholecystectomy: follow-up after combined surgical and radiologic management. Ann Surg 225:459–471
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Rao, P.P., Singh, A. & Singh, K.J. Bile Duct Injuries: Outcome of Early and Delayed Repair at a Tertiary Care Centre. Indian J Surg 83, 435–441 (2021). https://doi.org/10.1007/s12262-020-02393-7
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DOI: https://doi.org/10.1007/s12262-020-02393-7