Abstract
The investigation of prognostic factor for gastric cancer is still desirable because of dismal prognosis in gastric cancer. Lauren’s classification is currently a useful histological classification. There are few large series evaluating the prognostic significance of Lauren’s classification in gastric cancer. From January 1987 to December 2013, a total of 3071 patients received gastrectomy for gastric cancer. According Lauren’s classification, 1423(46.3 %) patients were intestinal type, 1000 patients (32.6 %) were diffuse type, and 648 patients (21.1 %) were mixed type. The clinicopathological characteristics and prognosis in Lauren’s classification were analyzed in these patients. Our results showed that patients with intestinal type gastric cancer (57.7 %) had a better 5-year overall survival than diffuse type (45.6 %) and mixed type (43.4 %, P < 0.001). The clinicopathological characteristics showed that gastric cancer patients with intestinal type were older (P < 0.001), male predominant (P < 0.001), smaller tumor size (P < 0.001), distal stomach predominant (P < 0.001), relative well differentiated (P < 0.001), less advanced Borrmann type (P < 0.001), less scirrhous type stromal reaction(P < 0.001), less infiltrating type of Ming’s histology type(P < 0.001), less tumor invasion depth and less lymphovascular invasion (P < 0.001). Multivariate analysis with overall survival as an endpoint showed that age (P = 0.005), Borrmann classification (P < 0.001), pathological T category (P = 0.023), pathological N category (P < 0.001) and Lauren’s classification (P = 0.003) were significant correlated in gastric cancer. Lauren’s classification is an independent prognostic factor in gastric cancer patient undergoing gastrectomy. Lauren’s classification can serve as a prognostic marker for gastric cancer patient receiving gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.
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Acknowledgment
We thank Miss L-J Dai (Department of Surgery, Taipei Veterans General Hospital) for her assistance in statistics. This research was supported by the Division of Experimental Surgery of the Department of Surgery in Taipei Veterans General Hospital, a grant from Taipei Veterans General Hospital (V104B-005) and grants from Ministry of Science and Technology (103-2314-B-075-043-, 104-2314-B-075-032-). All sources of funding have no role in the study design, data collection, analysis and interpretation of data, writing of the manuscript, and in the decision to submit the manuscript for publication.
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Lauren’s classification is an independent prognostic factor in gastric cancer after gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.
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Chen, YC., Fang, WL., Wang, RF. et al. Clinicopathological Variation of Lauren Classification in Gastric Cancer. Pathol. Oncol. Res. 22, 197–202 (2016). https://doi.org/10.1007/s12253-015-9996-6
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DOI: https://doi.org/10.1007/s12253-015-9996-6