Skip to main content

Advertisement

Log in

Clinicopathological Variation of Lauren Classification in Gastric Cancer

  • Original Article
  • Published:
Pathology & Oncology Research

Abstract

The investigation of prognostic factor for gastric cancer is still desirable because of dismal prognosis in gastric cancer. Lauren’s classification is currently a useful histological classification. There are few large series evaluating the prognostic significance of Lauren’s classification in gastric cancer. From January 1987 to December 2013, a total of 3071 patients received gastrectomy for gastric cancer. According Lauren’s classification, 1423(46.3 %) patients were intestinal type, 1000 patients (32.6 %) were diffuse type, and 648 patients (21.1 %) were mixed type. The clinicopathological characteristics and prognosis in Lauren’s classification were analyzed in these patients. Our results showed that patients with intestinal type gastric cancer (57.7 %) had a better 5-year overall survival than diffuse type (45.6 %) and mixed type (43.4 %, P < 0.001). The clinicopathological characteristics showed that gastric cancer patients with intestinal type were older (P < 0.001), male predominant (P < 0.001), smaller tumor size (P < 0.001), distal stomach predominant (P < 0.001), relative well differentiated (P < 0.001), less advanced Borrmann type (P < 0.001), less scirrhous type stromal reaction(P < 0.001), less infiltrating type of Ming’s histology type(P < 0.001), less tumor invasion depth and less lymphovascular invasion (P < 0.001). Multivariate analysis with overall survival as an endpoint showed that age (P = 0.005), Borrmann classification (P < 0.001), pathological T category (P = 0.023), pathological N category (P < 0.001) and Lauren’s classification (P = 0.003) were significant correlated in gastric cancer. Lauren’s classification is an independent prognostic factor in gastric cancer patient undergoing gastrectomy. Lauren’s classification can serve as a prognostic marker for gastric cancer patient receiving gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Taiwan Public Health Report 2012, Department of Health, Executive Yuan, R.O.C. (Taiwan)

  2. Wu CW, Hsiung CA, Lo SS et al (2006) Nodal dissection for patients with gastric cancer: a randomized controlled trial. Lancet Oncol 7:309–315

    Article  CAS  PubMed  Google Scholar 

  3. Hartgrink HH, van de Velde CJH, Putter H et al (2004) Extended lymph-node dissection for gastric cancer: who may benefit? final results of the randomized Dutch gastric cancer group trial. J Clin Oncol 22:2069–2077

    Article  CAS  PubMed  Google Scholar 

  4. Lauren P (1965) The two histologic main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma, an attempt at a histo-clinicalclassification. Acta Parhol Microb Scan 64:31–49

    CAS  Google Scholar 

  5. Qiu MZ, Cai MY, Zhang DS et al (2013) Clinicopathological characteristics and prognostic analysis of lauren classification in gastric adenocarcinoma in China. J Transl Med 11:58

    Article  PubMed Central  PubMed  Google Scholar 

  6. Berlth F, Bollschweiler E, Drebber U et al (2014) Pathohistological classification systems in gastric cancer: diagnostic relevance and prognostic value. World J Gastroenterol 20(19):5679–5684

    Article  PubMed Central  PubMed  Google Scholar 

  7. Ming SC (1977) Gastric carcinoma: a pathological classification. Cancer 39(6):2475–2485

    Article  CAS  PubMed  Google Scholar 

  8. American Joint Committee on Cancer (2010) AJCC cancer staging manual, 7th edn. Springer, New York

    Book  Google Scholar 

  9. Komatsu S, Ichikawa D, Miyamae M et al (2015) Histological mixed-type as an independent prognostic factor in stage I gastric carcinoma. World J Gastroenterol 21(2):549–555

    Article  PubMed Central  PubMed  Google Scholar 

  10. Zheng HC, Li XH, Hara T et al (2008) Mixed type gastric carcinoma exhibit more aggressive features and indicate the histogenesis of carcinomas. Virchows Arch 452(5):525–534

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Gravalos C, Jimeno A (2008) HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol 19(9):1523–1529

    Article  CAS  PubMed  Google Scholar 

  12. Qiu M, Zhou Y, Zhong X et al (2014) Lauren classification combined with HER2 status is a better prognostic factor in Chinese gastric cancer patients. BMC Cancer 14:823

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgment

We thank Miss L-J Dai (Department of Surgery, Taipei Veterans General Hospital) for her assistance in statistics. This research was supported by the Division of Experimental Surgery of the Department of Surgery in Taipei Veterans General Hospital, a grant from Taipei Veterans General Hospital (V104B-005) and grants from Ministry of Science and Technology (103-2314-B-075-043-, 104-2314-B-075-032-). All sources of funding have no role in the study design, data collection, analysis and interpretation of data, writing of the manuscript, and in the decision to submit the manuscript for publication.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kuo-Hung Huang.

Ethics declarations

Conflict of interest

All authors disclose no financial and personal relationships with other people or organizations that could inappropriately influence their work.

Additional information

Synopsis for table and contents

Lauren’s classification is an independent prognostic factor in gastric cancer after gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, YC., Fang, WL., Wang, RF. et al. Clinicopathological Variation of Lauren Classification in Gastric Cancer. Pathol. Oncol. Res. 22, 197–202 (2016). https://doi.org/10.1007/s12253-015-9996-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-015-9996-6

Keywords

Navigation