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Oxybenzone Entrapped in Mesoporous Silicate MCM-41

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Abstract

Purpose

Oxybenzone is an organic ultraviolet absorbent commonly used as photoprotection agent in cosmetic formulations. Unfortunately, it shows safety problems because of its potential systemic absorption and skin photosensibilization. Thus, a new particulate carrier is proposed with the aim of solving these problems.

Methods

Oxybenzone (OXY) was loaded into the mesopores of the silicate MCM-41 and the obtained particulate carrier (MCM-41-OXY) was mixed with melt tristearin or stearyl alcohol with the aim of plugging the MCM-41 mesopores and thus entrapped OXY inside the pores. These particles were characterized and incorporated in an emulgel. OXY release from these formulations was evaluated in vitro and was compared with those from emulgels containing free OXY and unplugged MCM-41-OXY. The photoprotection range of the hybrid materials was also investigated through spectrophotometric measurements.

Results

As concerns with UV absorption properties, it can be observed that the spectrum of the neat compound appears broader than those recorded for lipid/silicate particles and MCM-41-OXY, but MCM-41-OXY with tristearin presents a higher absorption intensity in UVA, UVB, and UVC regions, maintaining thus excellent photoprotection effects. Besides this aspect, the pore occlusion by means of the lipid ingredients offers a proper obstacle to sunscreen release, thus preventing the contact between the sunscreen and the skin and consequently both systemic absorption and cutaneous adverse reactions.

Conclusions

The new lipid/MCM-41 particles appear to be promising candidates to formulate sunscreen preparations.

Absorption spectra of neat OXY (black line) (a), MCM-41-OXY (red line) (b), MCM-41-OXYSTE (blue line) (c) and MCM-41-OXY- TRI (green line) (d) (on the left) and in vitro release profiles of OXY from neat OXY (a) and MCM-41-OXY (b) emulgels (on the right).

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Acknowledgments

The authors are very much grateful to Mr. Marco Marani, from the Dipartimento di Chimica e Tecnologia del Farmaco of the University of Perugia, Italy, for the technical assistance.

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Authors and Affiliations

  1. Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo 1, Perugia, 06123, Italy

    Valeria Ambrogi, Maria Cristina Tiralti & Maurizio Ricci

  2. CEMIN-Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 8, 06123, Perugia, Italy

    Loredana Latterini

  3. Dipartimento di Ingegneria Civile ed Ambientale, Via G. Duranti 93, Perugia, Italy

    Fabio Marmottini

Authors
  1. Valeria Ambrogi
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  2. Loredana Latterini
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  3. Fabio Marmottini
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  4. Maria Cristina Tiralti
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  5. Maurizio Ricci
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Correspondence to Valeria Ambrogi.

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Ambrogi, V., Latterini, L., Marmottini, F. et al. Oxybenzone Entrapped in Mesoporous Silicate MCM-41. J Pharm Innov 8, 212–217 (2013). https://doi.org/10.1007/s12247-013-9161-2

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  • DOI: https://doi.org/10.1007/s12247-013-9161-2

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