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Crosslinked Ionic Alginate and Cellulose-based Hydrogels for Photoresponsive Drug Release Systems

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Abstract

In this work, photosensitive alginate and cellulose-based hydrogels with interpenetrating polymer networks were successfully prepared from alginate, TEMPO-oxidized cellulose nanofibers (TEMPO-CNFs) and polyacrylamide, crosslinked by both Fe3+ and N,N′-methylenebis-acrylamide. The obtained hydrogels showed a clear relationship between the mechanical properties and the content of the TEMPO-CNFs. The results indicated that the mechanical properties of crosslinked hydrogels were enhanced with the mass ratio of TEMPO-CNFs and alginate increased from 1/2 to 2. Moreover, the crosslinked ionic alginate and cellulose-based hydrogels with various TEMPO-CNFs contents exhibited an interconnected porous morphology with an average pore size of ca. 130 µm, and demonstrated an increased cumulative release amount of BSA drugs under the ultraviolet irradiation. This study demonstrated that the as-prepared photoresponsive hydrogels would have a potential application as local drug release systems for wound dressings.

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References

  1. W. S. Toh and X. J. Loh, Mater. Sci. Eng. C, 45, 690 (2014).

    Article  CAS  Google Scholar 

  2. F. F. Azhar, E. Shahbazpour, and A. Olad, Fiber. Polym., 18, 416 (2017).

    Article  CAS  Google Scholar 

  3. S. Van Vlierberghe, P. Dubruel, and E. Schacht, Biomacromolecules, 12, 1387 (2011).

    Article  PubMed  CAS  Google Scholar 

  4. C. K. Kuo and P. X. Ma, Biomaterials, 22, 511 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. H. Chen, X. Xing, H. Tan, Y. Jia, T. Zhou, Y. Chen, Z. Ling, and X. Hu, Mater. Sci. Eng. C, 70, 287 (2017).

    Article  CAS  Google Scholar 

  6. B. V. Slaughter, S. S. Khurshid, O. Z. Fisher, A. Khademhosseini, and N. A. Peppas, Adv. Mater, 21, 3307 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. W. J. Zheng, N. An, J. H. Yang, J. Zhou, and Y. M. Chen, ACS Appl. Mater. Interfaces, 7, 1758 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. C. J. Carling, M. L. Viger, V. A. N. Huu, A. V. Garcia, and A. Almutairi, Chem. Sci., 6, 335 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. R. P. Narayanan, G. Melman, N. J. Letourneau, N. L. Mendelson, and A. Melman, Biomacromolecules, 13, 2465 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. N. Lin, C. C. Bruzzese, and A. Dufresne, ACS Appl. Mater. Interfaces, 4, 4948 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. G. E. Giammanco and A. D. Ostrowski, Chem. Mater., 27, 4922 (2015).

    Article  CAS  Google Scholar 

  12. K. Y. Lee and D. J. Mooney, Chem. Rev., 101, 1869 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. I. Machida-Sano, S. Ogawa, H. Ueda, Y. Kimura, N. Satoh, and H. Namiki, Int. J Biomater, 820513, 1 (2012).

    Article  CAS  Google Scholar 

  14. Z. Jin, G. R. Güven, V. Bocharova, J. Halámek, I. Tokarev, S. Minko, A. Melman, D. Mandler, and E. Katz, ACS Appl. Mater. Interfaces, 4, 466 (2012).

    Article  CAS  PubMed  Google Scholar 

  15. I. Machida-Sano, Y. Matsuda, and H. Namiki, Biomed. Mater, 4, 025008 (2009).

    Article  PubMed  CAS  Google Scholar 

  16. C. Y. Chiang and C. C. Chu, Carbohyd. Polym., 119, 18 (2015).

    Article  CAS  Google Scholar 

  17. R. J. Moon, A. Martini, J. Nairn, J. Simonsen, and J. Youngblood, Chem. Soc. Rev., 40, 3941 (2011).

    Article  CAS  PubMed  Google Scholar 

  18. E. J. Foster, R. J. Moon, U. R Agarwal, M. J. Bortner, J. Bras, S. Camarero-Espinosa, K. J. Chan, M. J. Clift, E. D. Cranston, and S. J. Eichhorn, Chem. Soc. Rev., 47, 2609 (2018).

    Article  CAS  PubMed  Google Scholar 

  19. G. K. Tummala, T. Joffre, V. R. Lopes, A. Liszka, O. Buznyk, N. Ferraz, C. Persson, M. Griffith, and A. Mihranyan, ACS Biomater Sci. Eng., 2, 2072 (2016).

    Article  CAS  PubMed  Google Scholar 

  20. G. K. Tummala, T. Joffre, R. Rojas, C. Persson, and A. Mihranyan, Soft Matter, 13, 3936 (2017).

    Article  CAS  PubMed  Google Scholar 

  21. N. Li, W. Chen, G. X. Chen, and J. F. Tian, Carbohyd. Polym., 171, 77 (2017).

    Article  CAS  Google Scholar 

  22. J. Yang, F. Xu, and C. R. Han, Biomacromolecules, 18, 1019 (2017).

    Article  CAS  PubMed  Google Scholar 

  23. N. E. Zander, H. Dong, J. Steele, and J. T. Grant, ACS Appl. Mater. Interfaces, 6, 18502 (2014).

    Article  CAS  PubMed  Google Scholar 

  24. G. E. Giammanco, C. T. Sosnofsky, and A. D. Ostrowski, ACS Appl. Mater. Interfaces, 7, 3068 (2015).

    Article  CAS  PubMed  Google Scholar 

  25. J. Y. Sun, X. Zhao, W. R. Illeperuma, O. Chaudhuri, K. H. Oh, D. J. Mooney, J. J. Vlassak, and Z. Suo, Nature, 489, 133 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. P. Lin, S. Ma, X. Wang, and F. Zhou, Adv. Mater, 27, 2054 (2015).

    Article  CAS  PubMed  Google Scholar 

  27. H. J. Zhang, X. J. Pang, and Y. Qi, RSC Adv., 5, 89073 (2015).

    Google Scholar 

  28. M. David, W. Dale, W. Meredith, D. Pierre-Emile, N. Jaan, N. T. Christopher, and W. F. Curtis, Polym. Advan. Technol., 19, 647 (2008).

    Article  CAS  Google Scholar 

  29. P. Mukhopadhyay, K. Sarkar, S. Bhattacharya, A. Bhattacharyya, R. Mishra, and P. P. Kundu, Carbohyd. Polym., 112, 627 (2014).

    Article  CAS  Google Scholar 

  30. B. Kundu and S. C. Kundu, Biomaterials, 33, 7456 (2012).

    Article  CAS  PubMed  Google Scholar 

  31. M. C. Darnell, J. Y. Sun, M. Mehta, C. Johnson, P. R. Arany, Z. Suo, and D. J. Mooney, Biomaterials, 34, 8042 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. T. Saito, S. Kimura, Y. Nishiyama, and A. Isogai, Bio¬macromolecules, 8, 2485 (2007).

    Article  CAS  Google Scholar 

  33. H. Fukuzumi, T. Saito, T. Iwata, Y. Kumamoto, and A. Isogai, Biomacromolecules, 10, 162 (2009).

    Article  CAS  PubMed  Google Scholar 

  34. T. Saito and A. Isogai, Biomacromolecules, 5, 1983 (2004).

    Article  CAS  PubMed  Google Scholar 

  35. D. H. Kim and D. C. Martin, Biomaterials, 27, 3031 (2006).

    Article  CAS  PubMed  Google Scholar 

  36. X. Z. Zhang, D. Q. Wu, and C. C. Chu, Biomaterials, 25, 3793 (2004).

    Article  CAS  PubMed  Google Scholar 

  37. K. Varaprasad, Y. M. Mohan, K. Vimala, and K. Mohana Raju, J. Appl. Polym. Sci., 121, 784 (2011).

    Article  CAS  Google Scholar 

  38. J. Yang and F. Xu, Biomacromolecules, 18, 2623 (2017).

    Article  CAS  PubMed  Google Scholar 

  39. K. J. Henderson, T. C. Zhou, K. J. Otim, and K. R. Shull, Macromolecules, 43, 6193 (2010).

    Article  CAS  Google Scholar 

  40. A. O. Elzoghby, W. M. Samy, and N. A. Elgindy, J. Control. Release, 157, 168 (2012).

    Article  CAS  PubMed  Google Scholar 

  41. P. Aslani and R. A. Kennedy, J. Control. Release, 42, 75 (1996).

    Article  CAS  Google Scholar 

  42. I. Bružauskaitė, D. Bironaitė, E. Bagdonas, and E. Bernotienė, Cytotechnology, 68, 355 (2016).

    Article  PubMed  CAS  Google Scholar 

  43. S. P. Miguel, M. P. Ribeiro, H. Brancal, P. Coutinho, and I. J. Correia, Carbohyd. Polym., 111, 366 (2014).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Textiles and Clothing, Qingdao University, Shandong, 266061, China

    Fang Zhou, Shaohua Wu, Jianwei Ma & Shaojuan Chen

  2. Department of Materials Science and Engineering, Virginia Tech, Virginia, 24061, USA

    Fang Zhou, Chris Rader & E. Johan Foster

  3. School of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China

    Fang Zhou & Xiaoyan Yuan

Authors
  1. Fang Zhou
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  2. Shaohua Wu
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  3. Chris Rader
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  4. Jianwei Ma
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  5. Shaojuan Chen
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  6. Xiaoyan Yuan
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  7. E. Johan Foster
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Correspondence to Fang Zhou or E. Johan Foster.

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Zhou, F., Wu, S., Rader, C. et al. Crosslinked Ionic Alginate and Cellulose-based Hydrogels for Photoresponsive Drug Release Systems. Fibers Polym 21, 45–54 (2020). https://doi.org/10.1007/s12221-020-9418-6

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  • DOI: https://doi.org/10.1007/s12221-020-9418-6

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