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Follow up of Children with Autism Spectrum Disorders: Stability and Change in Diagnosis

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Abstract

Objective

To assess diagnostic stability of initial autism spectrum disorder (ASD) diagnosed in children three years or less.

Methods

Participants in the study included 77 (64 boys,13 girls) children in whom a diagnosis of Autistic Disorder (AD) and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) was made at age 3 years or less as per the DSM IV criteria. Children were recruited from the Outpatient services of the department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh. Multi-disciplinary evaluations including neurological, diagnostic, cognitive, and behavioral assessments were made. In addition, the Childhood Autism Rating Scale (CARS) was administered to assess symptom severity. Follow up was done around 4 years of age.

Results

At Time 1, 64 (83.11%) children were diagnosed as AD and 13 (16.88%) children with PDD-NOS. Follow up was possible in only 43 children (55.8%) at the mean age of 4 years 1 month (SD = 0.99) after a mean age interval of 1.65 years (SD = 0.95). At Time 2, 37 (86%) children were diagnosed as AD and 4 (9.3%) children were diagnosed with PDD-NOS, and 2 (4.65%) children were found to be off the ASD spectrum. The diagnosis of ASD (AD and PDD-NOS) was stable over time and 41 (95.3%) out of 43 children retained an ASD diagnosis. Looking at specific ASD diagnosis, AD diagnosis was stable for 33 out of 37 (89.18%) children and the PDD-NOS was stable for only 1 out of 6 (16.67%) children.

Conclusions

An early and a stable diagnosis of ASD is possible provided there are expert clinicians available. Early detection and diagnosis of ASDs allows opportunities for children to profit more from early supports and interventions.

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References

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: American Psychiatric Association; 1994.

    Google Scholar 

  2. Kogan MD, Blumberg SJ, Schieve LA, et al. Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics. 2009;124:1–9.

    Article  Google Scholar 

  3. Johnson CP, Myers SM, the Council on Children with Disabilities. Identification and evaluation of children with autism spectrum disorders. Pediatrics. 2007;120:1183–215.

    Article  PubMed  Google Scholar 

  4. Filipek PA, Accardo PJ, Ashwal S, et al. Practice parameter: Screening and diagnosis of autism: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology. 2000;55:468–79.

    PubMed  CAS  Google Scholar 

  5. Zwaigenbaum L. Advances in the early detection of autism. Curr Opin Neurol. 2010;23:97–102.

    Article  PubMed  Google Scholar 

  6. Lord C. Follow-up of two-year-olds referred for possible autism. J Child Psychol Psychiatry. 1995;36:1365–82.

    Article  PubMed  CAS  Google Scholar 

  7. Stone W, Lee E, Ashford L, et al. Can autism be diagnosed accurately in children under 3 years? J Child Psychol Psychiatry. 1999;40:219–26.

    Article  PubMed  CAS  Google Scholar 

  8. Moore V, Goodson S. How well does early diagnosis of autism stand the test of time? Follow-up study of children assessed for autism at age 2 and development of an early diagnostic service. Autism. 2003;7:47–63.

    PubMed  Google Scholar 

  9. Eaves L, Ho H. Brief report: Stability and change in cognitive and behavioral characteristics of autism through childhood. J Autism Dev Disord. 2004;26:557–69.

    Article  Google Scholar 

  10. Kleinman J, Ventola P, Pandey J, et al. Diagnostic stability in very young children with autism spectrum disorders. J Autism Dev Disord. 2008;38:606–15.

    Article  PubMed  Google Scholar 

  11. Scambler DJ, Hepburn SL, Rogers SJ. A two-year follow-up on risk status identified by the checklist for autism in toddlers. J Dev Behav Pediatr. 2006;27:S104–10.

    Article  PubMed  Google Scholar 

  12. Alpern G, Boll T, Shearer M. Developmental Profile II (DP II). Los Angeles: Western Psychological Services; 1986.

    Google Scholar 

  13. Malin AJ. The Indian adaptation of the Vineland Social Maturity Scale. Lucknow: Indian Psychological Corporation; 1971.

    Google Scholar 

  14. Schopler E, Reichler R, Renner BR. The childhood autism rating scale. Los Angeles: Western Psychological Services; 1988.

    Google Scholar 

  15. Robins DL, Fein D, Barton ML, et al. The modified checklist for Autism in toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders. J Autism Dev Disord. 2001;31:131–44.

    Article  PubMed  CAS  Google Scholar 

  16. Kumar N, Shekhar C, Kumar P, et al. Kuppuswamy socio-economic scale-updating for 2007. Indian J Pediatr. 2007;74:1131–2.

    PubMed  CAS  Google Scholar 

  17. Sigman M, Ruskin E. Continuity and change in the social competence of children with autism, down syndrome, and developmental delays. Monogr Soc Res Child Dev. 1999;64:1–114.

    Article  PubMed  CAS  Google Scholar 

  18. Turner LM, Stone WL, Pozdol SL, et al. Follow-up of children with autism spectrum disorders from age 2 to age 9. Autism. 2006;10:243–65.

    Article  PubMed  Google Scholar 

  19. Matson J, Boisjoli J. Differential diagnosis of PDD-NOS in children. Res Autism Spectr Disord. 2007;1:75–84.

    Article  Google Scholar 

  20. Tidmarsh L, Volkmar F. Diagnosis and epidemiology of autism spectrum disorders. Can J Psychiatry. 2003;48:517–25.

    PubMed  Google Scholar 

  21. Volkmar F, Klin A, Siegel B, et al. Field trial for autistic disorder in DSM-IV. Am J Psychiatry. 1994;151:1361–7.

    PubMed  CAS  Google Scholar 

  22. Helt M, Kelley E, Kinsbourne M, et al. Can children with autism recover? If so, how? Neuropsychol Rev. 2008;18:339–66.

    Article  PubMed  Google Scholar 

  23. Sutera S, Pandey J, Esser E, et al. Predictors of optimal outcome in toddlers diagnosed with autism spectrum disorders. J Autism Dev Disord. 2007;37:98–107.

    Article  PubMed  Google Scholar 

  24. DeGiacomo A, Fombonne E. Parental recognition of developmental abnormalities in autism. Eur Child Adolesc Psychiatry. 1998;7:131–6.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India

    Prahbhjot Malhi & Pratibha Singhi

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  1. Prahbhjot Malhi
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  2. Pratibha Singhi
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Correspondence to Prahbhjot Malhi.

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Malhi, P., Singhi, P. Follow up of Children with Autism Spectrum Disorders: Stability and Change in Diagnosis. Indian J Pediatr 78, 941–945 (2011). https://doi.org/10.1007/s12098-011-0370-8

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