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Protective Effects of Humanin and Calmodulin-Like Skin Protein in Alzheimer’s Disease and Broad Range of Abnormalities

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Abstract

Humanin is a 24-amino acid, secreted bioactive peptide that prevents various types of cell death and improves some types of cell dysfunction. Humanin inhibits neuronal cell death that is caused by a familial Alzheimer’s disease (AD)-linked gene via binding to the heterotrimeric Humanin receptor (htHNR). This suggests that Humanin may play a protective role in AD-related pathogenesis. Calmodulin-like skin protein (CLSP) has recently been identified as a physiological agonist of htHNR with 105-fold more potent anti-cell death activity than Humanin. Humanin has also shown to have protective effects against some metabolic disorders. In this review, the broad range of functions of Humanin and the functions of CLSP that have been characterized thus far are summarized.

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Acknowledgments

The author is grateful to Ms. Takako Hiraki for the secretarial assistance.

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The author declares that he has no conflict of interest.

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  1. Department of Pharmacology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Masaaki Matsuoka

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Matsuoka, M. Protective Effects of Humanin and Calmodulin-Like Skin Protein in Alzheimer’s Disease and Broad Range of Abnormalities. Mol Neurobiol 51, 1232–1239 (2015). https://doi.org/10.1007/s12035-014-8799-1

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