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Down-regulation of miR-126 expression in colorectal cancer and its clinical significance

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Abstract

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-126 in colorectal cancers are unclear. In this study, we compared the expression of miR-126 between colorectal cancer tissues and non-tumor tissues. The expression levels of miR-126 in colorectal cancer tissues were significantly lower than those in non-tumor tissues, and miR-126 overexpression inhibited the growth of colorectal cancer cells. This new information may help to clarify the molecular mechanisms involved in colorectal carcinogenesis and to indicate that miR-126 may be a novel suppressive microRNA and help to differentiate between malignant and normal colorectal tissue.

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Abbreviations

CRC:

Colorectal cancer

TNM:

Tumor-node-metastasis

miRNAs:

microRNAs

CEA:

Carcinoembryonic antigen

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Acknowledgments

The authors thank Dr. Yanhong Zhou for guidance in data analysis.

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Authors and Affiliations

  1. Emergency Department of Xiangya Hospital, Central South University, 410008, Changsha, China

    Xiang-Min Li, Ai-Min Wang & Juan Zhang

  2. Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, 410008, Changsha, China

    Hong Yi

Authors
  1. Xiang-Min Li
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  2. Ai-Min Wang
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  3. Juan Zhang
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  4. Hong Yi
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Corresponding author

Correspondence to Xiang-Min Li.

Additional information

Xiang-Min Li and Ai-Min Wang contributed equally to this work.

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Li, XM., Wang, AM., Zhang, J. et al. Down-regulation of miR-126 expression in colorectal cancer and its clinical significance. Med Oncol 28, 1054–1057 (2011). https://doi.org/10.1007/s12032-010-9637-6

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  • DOI: https://doi.org/10.1007/s12032-010-9637-6

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