Abstract
Ileal neuroendocrine tumors (NETs) often progress slowly, but because of their generally nonspecific symptoms, they have often metastasized to local lymph nodes and to the liver by the time the patient presents. Biochemically, most of these patients have increased levels of whole blood serotonin, urinary 5-hydroxyindoleacetic acid, and chromogranin A. Imaging work-up generally comprises computed tomography or magnetic resonance imaging and somatostatin receptor scintigraphy, or in recent years positron emission tomography with 68Ga-labeled somatostatin analogs, allowing for detection of even sub-cm lesions. Carcinoid heart disease with affected leaflets, mainly to the right side of the heart, is a well-known complication and patients routinely undergo echocardiography to diagnose and monitor this. Multitasking surgery is currently recognized as first-line treatment for ileal NETs with metastases and carcinoid heart disease. Open heart surgery and valve replacement are advocated in patients with valvular disease and progressive heart failure. When valvulopathy in the tricuspid valve results in right-sided heart failure, a sequential approach, performing valve replacement first before intra-abdominal tumor-reductive procedures are conducted, reduces the risk of bleeding. Metastases to the myocardium from ileal NETs are seen in <1–4.3 % of patients, depending partly on the imaging technique used, and are generally discovered in those affected with widespread disease. Systemic treatment with somatostatin analogs, and sometimes alpha interferon, is first-line medical therapy in metastatic disease to relieve hormonal symptoms and stabilize the tumor. This treatment is also indicated when heart metastases are detected, with the addition of diuretics and fluid restriction in cases of heart failure. Myocardial metastases are rarely treated by surgical resection.
Similar content being viewed by others
References
J.C. Yao, M. Hassan, A. Phan, C. Dagohoy, C. Leary, J.E. Mares, E.K. Abdalla, J.B. Fleming, J.N. Vauthey, A. Rashid, D.B. Evans, One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J. Clin. Oncol. 26(18), 3063–3072 (2008). doi:10.1200/JCO.2007.15.4377
H. Martensson, A. Nobin, F. Sundler, Carcinoid tumors in the gastrointestinal tract–an analysis of 156 cases. Acta. Chir. Scand. 149(6), 607–616 (1983)
J.M. Zuetenhorst, B.G. Taal, Metastatic carcinoid tumors: a clinical review. Oncologist 10(2), 123–131 (2005). doi:10.1634/theoncologist.10-2-123
R. Hlatky, D. Suki, R. Sawaya, Carcinoid metastasis to the brain. Cancer 101(11), 2605–2613 (2004). doi:10.1002/cncr.20659
K. Tornebrandt, J. Eskilsson, A. Nobin, Heart involvement in metastatic carcinoid disease. Clin. Cardiol. 9(1), 13–19 (1986)
S. Bhattacharyya, J. Davar, G. Dreyfus, M.E. Caplin, Carcinoid heart disease. Circulation 116(24), 2860–2865 (2007). doi:10.1161/CIRCULATIONAHA.107.701367
U.H. Pandya, P.A. Pellikka, M. Enriquez-Sarano, W.D. Edwards, H.V. Schaff, H.M. Connolly, Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients. J. Am. Coll. Cardiol. 40(7), 1328–1332 (2002)
J. Calissendorff, A. Sundin, H. Falhammar, Ga-DOTA-TOC-PET/CT detects heart metastases from ileal neuroendocrine tumors. Endocrine 47(1), 169–176 (2014)
D.J. Kwekkeboom, Myocardial metastases from neuroendocrine tumors: incidence and relevance. Endocrine (2014). doi:10.1007/s12020-014-0272-4
S. Marechaux, J. Dagorn, V. Gaxotte, P.V. Ennezat, J.P. Beregi, C. Bauters, G. Deklunder, T. le Tourneau, Myocardial metastasis of a bronchial carcinoid. Eur. Heart J. 28(4), 391 (2007). doi:10.1093/eurheartj/ehl237
H. Jann, T. Wertenbruch, U. Pape, C. Ozcelik, T. Denecke, S. Mehl, B. Wiedenmann, M. Pavel, A matter of the heart: myocardial metastases in neuroendocrine tumors. Horm. Metab. Res. 42(13), 967–976 (2010). doi:10.1055/s-0030-1267204
V.L. Schiller, M.C. Fishbein, R.J. Siegel, Unusual cardiac involvement in carcinoid syndrome. Am. Heart J. 112(6), 1322–1323 (1986)
T. Sabatini, R. Rozzini, G.B. Morandi, F. Meriggi, F. Zorzi, Primary carcinoid tumor of the ovary: report of an unusual case. Tumori 86(1), 91–94 (2000)
P. Haemers, K. Dujardin, An unusual cause of carcinoid heart disease. Acta Cardiol. 65(6), 709–712 (2010)
S.N. Fine, M.L. Gaynor, O.W. Isom, A.J. Dannenberg, Carcinoid tumor metastatic to the heart. Am. J. Med. 89(5), 690–692 (1990)
P.A. Pellikka, A.J. Tajik, B.K. Khandheria, J.B. Seward, J.A. Callahan, H.C. Pitot, L.K. Kvols, Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Circulation 87(4), 1188–1196 (1993)
C. Carreras, H.R. Kulkarni, R.P. Baum, Rare metastases detected by (68)Ga-somatostatin receptor PET/CT in patients with neuroendocrine tumors. Recent Results Cancer Res. 194, 379–384 (2013). doi:10.1007/978-3-642-27994-2_20
N. Chaowalit, H.M. Connolly, H.V. Schaff, M.J. Webb, P.A. Pellikka, Carcinoid heart disease associated with primary ovarian carcinoid tumor. Am. J. cardiol. 93(10), 1314–1315 (2004). doi:10.1016/j.amjcard.2004.01.075
A.M. Bernheim, H.M. Connolly, P.A. Pellikka, Carcinoid heart disease in patients without hepatic metastases. Am. J. cardiol. 99(2), 292–294 (2007). doi:10.1016/j.amjcard.2006.07.092
C.M. Korse, B.G. Taal, C.A. de Groot, R.H. Bakker, J.M. Bonfrer, Chromogranin-A and N-terminal pro-brain natriuretic peptide: an excellent pair of biomarkers for diagnostics in patients with neuroendocrine tumor. J. Clin. Oncol. 27(26), 4293–4299 (2009). doi:10.1200/JCO.2008.18.7047
H.M. Connolly, R.A. Nishimura, H.C. Smith, P.A. Pellikka, C.J. Mullany, L.K. Kvols, Outcome of cardiac surgery for carcinoid heart disease. J. Am. Coll. Cardiol. 25(2), 410–416 (1995)
G. Westberg, B. Wangberg, H. Ahlman, C.H. Bergh, M. Beckman-Suurkula, K. Caidahl, Prediction of prognosis by echocardiography in patients with midgut carcinoid syndrome. Br. J. Surg. 88(6), 865–872 (2001). doi:10.1046/j.0007-1323.2001.01798.x
J.E. Moller, P.A. Pellikka, A.M. Bernheim, H.V. Schaff, J. Rubin, H.M. Connolly, Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation 112(21), 3320–3327 (2005). doi:10.1161/CIRCULATIONAHA.105.553750
M.B. Jacobsen, S. Nitter-Hauge, P.E. Bryde, L.E. Hanssen, Cardiac manifestations in mid-gut carcinoid disease. Eur. Heart J. 16(2), 263–268 (1995)
N.M. Rajamannan, N. Caplice, F. Anthikad, T.J. Sebo, T.A. Orszulak, W.D. Edwards, J. Tajik, R.S. Schwartz, Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects. J. Heart Valve Dis. 10(6), 827–831 (2001)
S.L. Lee, W.W. Wang, G.A. Finlay, B.L. Fanburg, Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion. Am. J. Physiol. 277(2 Pt 1), L282–L291 (1999)
C. Coatrieux, M. Sanson, A. Negre-Salvayre, A. Parini, Y. Hannun, S. Itohara, R. Salvayre, N. Auge, MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Free Radic. Biol. Med. 43(1), 80–89 (2007). doi:10.1016/j.freeradbiomed.2007.03.036
R.A. Pena-Silva, J.D. Miller, Y. Chu, D.D. Heistad, Serotonin produces monoamine oxidase-dependent oxidative stress in human heart valves. Am. J. Physiol. Heart Circ. Physiol. 297(4), H1354–H1360 (2009). doi:10.1152/ajpheart.00570.2009
I. Norheim, K. Oberg, E. Theodorsson-Norheim, P.G. Lindgren, G. Lundqvist, A. Magnusson, L. Wide, E. Wilander, Malignant carcinoid tumors. An analysis of 103 patients with regard to tumor localization, hormone production, and survival. Ann. Surg. 206(2), 115–125 (1987)
A. Roy, N.J. Brand, M.H. Yacoub, Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves. J. Heart Valve Dis. 9(2), 256–260 (2000). discussion 260–251
B. Svejda, M. Kidd, F. Giovinazzo, K. Eltawil, B.I. Gustafsson, R. Pfragner, I.M. Modlin, The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer 116(12), 2902–2912 (2010). doi:10.1002/cncr.25049
B.I. Gustafsson, K. Tommeras, I. Nordrum, J.P. Loennechen, A. Brunsvik, E. Solligard, R. Fossmark, I. Bakke, U. Syversen, H. Waldum, Long-term serotonin administration 22 induces heart valve disease in rats. Circulation 111(12), 1517–1522 (2005). doi:10.1161/01.CIR.0000159356.42064.48
D.S. Bergestuen, T. Edvardsen, S. Aakhus, T. Ueland, E. Oie, M. Vatn, P. Aukrust, E. Thiis-Evensen, Activin A in carcinoid heart disease: a possible role in diagnosis and pathogenesis. Neuroendocrinology 92(3), 168–177 (2010). doi:10.1159/000318014
D.S. Bergestuen, J. Gravning, K.H. Haugaa, L.G. Sahakyan, S. Aakhus, E. Thiis-Evensen, E. Oie, P. Aukrust, H. Attramadal, T. Edvardsen, Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors. BMC Cancer 10, 6 (2010). doi:10.1186/1471-2407-10-6
M.D. Kerstein, L.H. Cronau, S.D. Mandel, C.N. Gillis, Effect of hemorrhagic shock on 5-hydroxytryptamine removal by the lung. Am. Surg. 48(12), 644–646 (1982)
E.B. Olson Jr, M. Ghias-Ud-Din, J. Rankin, Serotonin uptake and metabolism in isolated, perfused fetal, newborn and adult rabbit lungs. Lung 161(3), 173–179 (1983)
N. Mansencal, E. Mitry, J.F. Forissier, F. Martin, A. Redheuil, C. Lepere, J.C. Farcot, T. Joseph, P. Lacombe, P. Rougier, O. Dubourg, Assessment of patent foramen ovale in carcinoid heart disease. Am. Heart J. 151(5), 1129 e1121–1126 (2006). doi:10.1016/j.ahj.2006.02.019
N. Mansencal, E. Mitry, R. Pilliere, C. Lepere, B. Gerardin, J. Petit, I. Gandjbakhch, P. Rougier, O. Dubourg, Prevalence of patent foramen ovale and usefulness of percutaneous closure device in carcinoid heart disease. Am. J. Cardiol. 101(7), 1035–1038 (2008). doi:10.1016/j.amjcard.2007.11.056
D.V. Simula, W.D. Edwards, H.D. Tazelaar, H.M. Connolly, H.V. Schaff, Surgical pathology of carcinoid heart disease: a study of 139 valves from 75 patients spanning 20 years. Mayo Clin. Proc. 77(2), 139–147 (2002). doi:10.4065/77.2.139
R. Dobson, D.J. Cuthbertson, M.I. Burgess, The optimal use of cardiac imaging in the quantification of carcinoid heart disease. Endocr. Relat. Cancer 20(5), R247–R255 (2013). doi:10.1530/ERC-13-0152
L.R. Woodbridge, B.M. Murtagh, D.F. Yu, K.L. Planche, Midgut neuroendocrine tumors: imaging assessment for surgical resection. Radiographics 34(2), 413–426 (2014). doi:10.1148/rg.342135504
S. Bhattacharyya, C. Toumpanakis, D. Chilkunda, M.E. Caplin, J. Davar, Risk factors for the development and progression of carcinoid heart disease. Am. J. Cardiol. 107(8), 1221–1226 (2011). doi:10.1016/j.amjcard.2010.12.025
L.G. Rudski, W.W. Lai, J. Afilalo, L. Hua, M.D. Handschumacher, K. Chandrasekaran, S.D. Solomon, E.K. Louie, N.B. Schiller, Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J. Am. Soc. Echocardiogr. 23(7), 685–713 (2010). doi:10.1016/j.echo.2010.05.010. quiz 786–688
U.F. Pape, A. Perren, B. Niederle, D. Gross, T. Gress, F. Costa, R. Arnold, T. Denecke, U. Plockinger, R. Salazar, A. Grossman, Barcelona Consensus Conference, p.: ENETS Consensus Guidelines for the management of patients with neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas. Neuroendocrinology 95(2), 135–156 (2012). doi:10.1159/000335629
W.D. Denney, W.E. Kemp Jr, L.B. Anthony, J.A. Oates, B.F. Byrd 3rd, Echocardiographic and biochemical evaluation of the development and progression of carcinoid heart disease. J. Am. Coll. Cardiol. 32(4), 1017–1022 (1998)
J.E. Moller, H.M. Connolly, J. Rubin, J.B. Seward, K. Modesto, P.A. Pellikka, Factors associated with progression of carcinoid heart disease. N. Engl. J. Med. 348(11), 1005–1015 (2003). doi:10.1056/NEJMoa021451
N. Mansencal, W.J. McKenna, E. Mitry, A. Beauchet, D. Pellerin, P. Rougier, O. Dubourg, Comparison of prognostic value of tissue Doppler imaging in carcinoid heart disease versus the value in patients with the carcinoid syndrome but without carcinoid heart disease. Am. J. Cardiol. 105(4), 527–531 (2010). doi:10.1016/j.amjcard.2009.10.023
S. Bhattacharyya, C. Toumpanakis, M.E. Caplin, J. Davar, Usefulness of N-terminal pro-brain natriuretic peptide as a biomarker of the presence of carcinoid heart disease. Am. J. Cardiol. 102(7), 938–942 (2008). doi:10.1016/j.amjcard.2008.05.047
R.M. Lang, L.P. Badano, W. Tsang, D.H. Adams, E. Agricola, T. Buck, F.F. Faletra, A. Franke, J. Hung, L.P. de Isla, O. Kamp, J.D. Kasprzak, P. Lancellotti, T.H. Marwick, M.L. McCulloch, M.J. Monaghan, P. Nihoyannopoulos, N.G. Pandian, P.A. Pellikka, M. Pepi, D.A. Roberson, S.K. Shernan, G.S. Shirali, L. Sugeng, F.J. Ten Cate, M.A. Vannan, J.L. Zamorano, W.A. Zoghbi, American Society of Echocardiography, European Association of, Echocardiography, EAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography. Eur. Heart J. Cardiovasc. Imaging. 13(1), 1–46 (2012). doi:10.1093/ehjci/jer316
G. Leibundgut, A. Rohner, L. Grize, A. Bernheim, A. Kessel-Schaefer, J. Bremerich, M. Zellweger, P. Buser, M. Handke, Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic resonance imaging in 100 adult patients. J Am Soc Echocardiogr. 23(2), 116–126 (2010). doi:10.1016/j.echo.2009.11.016
J.K. Ramage, A. Ahmed, J. Ardill, N. Bax, D.J. Breen, M.E. Caplin, P. Corrie, J. Davar, A.H. Davies, V. Lewington, T. Meyer, J. Newell-Price, G. Poston, N. Reed, A. Rockall, W. Steward, R.V. Thakker, C. Toubanakis, J. Valle, C. Verbeke, A.B. Grossman, UK, Ireland Neuroendocrine Tumour Society, Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs). Gut 61(1), 6–32 (2012). doi:10.1136/gutjnl-2011-300831
A.I. Vinik, E.A. Woltering, R.R. Warner, M. Caplin, T.M. O’Dorisio, G.A. Wiseman, D. Coppola, V.L. Go, North American Neuroendocrine Tumor, S.: nANETS consensus guidelines for the diagnosis of neuroendocrine tumor. Pancreas 39(6), 713–734 (2010). doi:10.1097/MPA.0b013e3181ebaffd
B. Eriksson, G. Kloppel, E. Krenning, H. Ahlman, U. Plockinger, B. Wiedenmann, R. Arnold, C. Auernhammer, M. Korner, G. Rindi, S. Wildi, Frascati Consensus Conference, p.: consensus guidelines for the management of patients with digestive neuroendocrine tumors–well-differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 87(1), 8–19 (2008). doi:10.1159/000111034
S. Bhattacharyya, S.G. Raja, C. Toumpanakis, M.E. Caplin, G.D. Dreyfus, J. Davar, Outcomes, risks and complications of cardiac surgery for carcinoid heart disease. Eur. J. Cardiothorac. Surg. 40(1), 168–172 (2011). doi:10.1016/j.ejcts.2010.10.035
L. Lundin, H.E. Hansson, J. Landelius, K. Oberg, Surgical treatment of carcinoid heart disease. J Thorac Cardiovasc Surg 100(4), 552–561 (1990)
F. Grothues, G.C. Smith, J.C. Moon, N.G. Bellenger, P. Collins, H.U. Klein, D.J. Pennell, Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am. J. Cardiol. 90(1), 29–34 (2002)
K. Alfakih, H. Thiele, S. Plein, G.J. Bainbridge, J.P. Ridgway, M.U. Sivananthan, Comparison of right ventricular volume measurement between segmented k-space gradient-echo and 24 steady-state free precession magnetic resonance imaging. J Magn. Reson. Imaging 16(3), 253–258 (2002). doi:10.1002/jmri.10164
H. Sandmann, M. Pakkal, R. Steeds, Cardiovascular magnetic resonance imaging in the assessment of carcinoid heart disease. Clin. Radiol. 64(8), 761–766 (2009). doi:10.1016/j.crad.2008.10.013
D. Franzen, A. Boldt, U. Raute-Kreinsen, R. Koerfer, E. Erdmann, Magnetic resonance imaging of carcinoid heart disease. Clin. Cardiol. 32(6), E92–E93 (2009). doi:10.1002/clc.20260
J.G. Castillo, F. Filsoufi, P.B. Rahmanian, A. Anyanwu, J.S. Zacks, R.R. Warner, D.H. Adams, Early and late results of valvular surgery for carcinoid heart disease. J. Am. Coll. Cardiol. 51(15), 1507–1509 (2008). doi:10.1016/j.jacc.2007.12.036
R. Martos, C. Ridge, M. Quinn, J. Dodd, Cardiac carcinoid: tricuspid delayed hyperenhancement on cardiac 64-slice multidetector CT and magnetic resonance imaging. Ir. J. Med. Sci. 179(3), 447–449 (2010). doi:10.1007/s11845-008-0273-5
M.L. Diaz, A. Villanueva, G. Bastarrika, B. Zudaire, L.G. del Barrio, J.J. Noguera, Non-electrocardiogram-gated multidetector-row computed tomography findings of cardiac pathology in oncologic patients. Curr. Probl. Diagn. Radiol. 38(5), 206–217 (2009). doi:10.1067/j.cpradiol.2008.05.003
N.E. Manghat, V. Rachapalli, R. Van Lingen, A.M. Veitch, C.A. Roobottom, G.J. Morgan-Hughes, Imaging the heart valves using ECG-gated 64-detector row cardiac CT. Br. J. Radiol. 81(964), 275–290 (2008). doi:10.1259/bjr/16301537
J.F. Deloach, J.W. Haynes, Secondary tumors of heart and pericardium; review of the subject and report of one hundred thirty-seven cases. AMA Arch. Intern. Med. 91(2), 224–249 (1953)
C. Chiles, P.K. Woodard, F.R. Gutierrez, K.M. Link, Metastatic involvement of the heart and pericardium: CT and MR imaging. Radiographics 21(2), 439–449 (2001)
E.C. Klatt, D.R. Heitz, Cardiac metastases. Cancer 65(6), 1456–1459 (1990)
P.J. Peters, S. Reinhardt, The echocardiographic evaluation of intracardiac masses: a review. J. Am. Soc. Echocardiogr. 19(2), 230–240 (2006). doi:10.1016/j.echo.2005.10.015
K.A. Ekmektzoglou, G.F. Samelis, T. Xanthos, Heart and tumors: location, metastasis, clinical manifestations, diagnostic approaches and therapeutic considerations. J. Cardiovasc. Med. (Hagerstown) 9(8), 769–777 (2008). doi:10.2459/JCM.0b013e3282f88e49
C.N. Patel, A. Anthoney, D. Treanor, A.F. Scarsbrook, Solitary myocardial metastasis from small-bowel neuroendocrine carcinoma. J. Clin. Oncol 27(10), 1724–1726 (2009). doi:10.1200/JCO.2008.19.9232
J. Meurice, S. Boule, G. Deswarte, F. Brigadeau, T. Modine, Solitary atrial myocardial metastasis revealing ileal neuroendocrine carcinoma. Cardiovasc. Pathol. 21(4), 355–357 (2012). doi:10.1016/j.carpath.2011.10.003
K.J. Lu, V. Rathi, P. Calafiore, G. Smith, P.M. Srivastava, Multimodality imaging in an unusual case of palpitations and right heart failure. Circulation 124(10), e254–e257 (2011). doi:10.1161/CIRCULATIONAHA.111.037606
V.S. Kasi, A.N. Ahsanuddin, C. Gilbert, L. Orr, J. Moran, V.L. Sorrell, Isolated metastatic myocardial carcinoid tumor in a 48-year-old man. Mayo Clin. Proc. 77(6), 591–594 (2002)
M. Matsumura, S. Takamoto, S. Kyo, Y. Yokote, R. Omoto, Advantages of transesophageal color Doppler echocardiography in the diagnosis and surgical treatment of cardiac masses. J. Cardiol. 20(3), 701–714 (1990)
J.H. Goldman, E. Foster, Transesophageal echocardiographic (TEE) evaluation of intracardiac and pericardial masses. Cardiol. Clin. 18(4), 849–860 (2000)
M.K. Kalra, S. Abbara, Imaging cardiac tumors. Cancer Treat. Res. 143, 177–196 (2008)
E.G. Amparo, C.B. Higgins, D. Farmer, G. Gamsu, M. McNamara, Gated MRI of cardiac and paracardiac masses: initial experience. AJR Am. J. Roentgenol. 143(6), 1151–1156 (1984)
D.J. Shah, Evaluation of cardiac masses: the role of cardiovascular magnetic resonance. Methodist. Debakey. Cardiovasc. J. 6(3), 4–11 (2010)
B.H. Gross, G.M. Glazer, I.R. Francis, CT of intracardiac and intrapericardial masses. AJR Am. J. Roentgenol. 140(5), 903–907 (1983)
G.A. Krombach, E. Spuentrup, A. Buecker, A.H. Mahnken, M. Katoh, Y. Temur, C.B. Higgins, R.W. Gunther, Heart tumors: magnetic resonance imaging and multislice spiral CT. Rofo 177(9), 1205–1218 (2005). doi:10.1055/s-2005-858489
V. Ambrosini, D. Campana, L. Bodei, C. Nanni, P. Castellucci, V. Allegri, G.C. Montini, P. Tomassetti, G. Paganelli, S. Fanti, 68Ga-DOTANOC PET/CT clinical impact in patients with neuroendocrine tumors. J. Nucl. Med. 51(5), 669–673 (2010). doi:10.2967/jnumed.109.071712
A. Frilling, G.C. Sotiropoulos, A. Radtke, M. Malago, A. Bockisch, H. Kuehl, J. Li, C.E. Broelsch, The impact of 68Ga-DOTATOC positron emission tomography/computed tomography on the multimodal management of patients with neuroendocrine tumors. Ann. Surg. 252(5), 850–856 (2010). doi:10.1097/SLA.0b013e3181fd37e8
H. Geijer, L.H. Breimer, Somatostatin receptor PET/CT in neuroendocrine tumours: update on systematic review and meta-analysis. Eur. J. Nucl. Med. Mol. Imaging (2013). doi:10.1007/s00259-013-2482-z
G. Treglia, P. Castaldi, G. Rindi, A. Giordano, V. Rufini, Diagnostic performance of Gallium-68 somatostatin receptor PET and PET/CT in patients with thoracic and gastroenteropancreatic neuroendocrine tumours: a meta-analysis. Endocrine 42(1), 80–87 (2012). doi:10.1007/s12020-012-9631-1
M. Gabriel, C. Decristoforo, D. Kendler, G. Dobrozemsky, D. Heute, C. Uprimny, P. Kovacs, E. Von Guggenberg, R. Bale, I.J. Virgolini, 68 Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J. Nucl. Med. 48(4), 508–518 (2007)
S. Balogova, J.N. Talbot, V. Nataf, L. Michaud, V. Huchet, K. Kerrou, F. Montravers, 18F-fluorodihydroxyphenylalanine vs other radiopharmaceuticals for imaging neuroendocrine tumours according to their type. Eur. J. Nucl. Med. Mol. Imaging 40(6), 943–966 (2013). doi:10.1007/s00259-013-2342-x
M. Schindl, K. Kaczirek, C. Passler, K. Kaserer, G. Prager, C. Scheuba, M. Raderer, B. Niederle, Treatment of small intestinal neuroendocrine tumors: is an extended multimodal approach justified? World J. Surg. 26(8), 976–984 (2002). doi:10.1007/s00268-002-6628-6
P. Hellman, T. Lundstrom, U. Ohrvall, B. Eriksson, B. Skogseid, K. Oberg, Tiensuu Janson, E., Akerstrom, G.: effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastases. World J. Surg. 26(8), 991–997 (2002). doi:10.1007/s00268-002-6630-z
A. Rinke, H.H. Muller, C. Schade-Brittinger, K.J. Klose, P. Barth, M. Wied, C. Mayer, B. Aminossadati, U.F. Pape, M. Blaker, J. Harder, C. Arnold, T. Gress, R. Arnold, Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in 26 the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J. Clin. Oncol. 27(28), 4656–4663 (2009). doi:10.1200/JCO.2009.22.8510
A. Kubota, Y. Yamada, S. Kagimoto, A. Shimatsu, M. Imamura, K. Tsuda, H. Imura, S. Seino, Y. Seino, Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors. J. Clin. Investig. 93(3), 1321–1325 (1994). doi:10.1172/JCI117090
W.L. Leong, J.L. Pasieka, Regression of metastatic carcinoid tumors with octreotide therapy: two case reports and a review of the literature. J. Surg. Oncol. 79(3), 180–187 (2002)
M.E. Caplin, M. Pavel, J.B. Cwikla, A.T. Phan, M. Raderer, E. Sedlackova, G. Cadiot, E.M. Wolin, J. Capdevila, L. Wall, G. Rindi, A. Langley, S. Martinez, J. Blumberg, P. Ruszniewski, C. Investigators, Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N. Engl. J. Med. 371(3), 224–233 (2014). doi:10.1056/NEJMoa1316158
K. Oberg, Biotherapies for GEP-NETs. Best Pract. Res. Clin. Gastroenterol. 26(6), 833–841 (2012). doi:10.1016/j.bpg.2013.01.001
T. Steinmuller, R. Kianmanesh, M. Falconi, A. Scarpa, B. Taal, D.J. Kwekkeboom, J.M. Lopes, A. Perren, G. Nikou, J. Yao, G.F. DelleFave, D. O’Toole, Frascati Consensus Conference participants, Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 87(1), 47–62 (2008). doi:10.1159/000111037
M. Pavel, E. Baudin, A. Couvelard, E. Krenning, K. Oberg, T. Steinmuller, M. Anlauf, B. Wiedenmann, R. Salazar, Barcelona Consensus Conference, p.: ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 95(2), 157–176 (2012). doi:10.1159/000335597
D.J. Kwekkeboom, W.W. de Herder, C.H. van Eijck, B.L. Kam, M. van Essen, J.J. Teunissen, E.P. Krenning, Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors. Semin. Nucl. Med. 40(2), 78–88 (2010). doi:10.1053/j.semnuclmed.2009.10.004
J.W. Askew, H.M. Connolly, Carcinoid valve disease. Curr Treat Options Cardiovasc Med 15(5), 544–555 (2013). doi:10.1007/s11936-013-0265-2
J.B. Lillegard, J.E. Fisher, T.J. McKenzie, F.G. Que, M.B. Farnell, M.L. Kendrick, J.H. Donohue, K. Reid-Lombardo, H.V. Schaff, H.M. Connolly, D.M. Nagorney, Hepatic resection for the carcinoid syndrome in patients with severe carcinoid heart disease: does valve replacement permit safe hepatic resection? J. Am. Coll. Surg. 213(1), 130–136 (2011). doi:10.1016/j.jamcollsurg.2011.03.029. discussion 136-138
A.M. Bernheim, H.M. Connolly, J. Rubin, J.E. Moller, C.G. Scott, D.M. Nagorney, P.A. Pellikka, Role of hepatic resection for patients with carcinoid heart disease. Mayo Clin. Proc. 83(2), 143–150 (2008). doi:10.4065/83.2.143
E. McAlindon, M. Peterson, A. Bryan, M. Townsend, Quadruple valve replacement for valve destruction in carcinoid heart disease. Eur. Heart J. 32(15), 1946 (2011). doi:10.1093/eurheartj/ehr089
P.M. Ridker, G.M. Chertow, E.W. Karlson, A.S. Neish, F.J. Schoen, Bioprosthetic tricuspid valve stenosis associated with extensive plaque deposition in carcinoid heart disease. Am. Heart J. 121(6 Pt 1), 1835–1838 (1991)
A.M. Bernheim, H.M. Connolly, T.J. Hobday, M.D. Abel, P.A. Pellikka, Carcinoid heart disease. Prog. Cardiovasc. Dis. 49(6), 439–451 (2007). doi:10.1016/j.pcad.2006.12.00227
S.V. Pislaru, I. Hussain, P.A. Pellikka, J.J. Maleszewski, R.D. Hanna, H.V. Schaff, H.M. Connolly, Misconceptions, diagnostic challenges and treatment opportunities in bioprosthetic valve thrombosis: lessons from a case series. Eur. J. Cardiothorac. Surg. (2014). doi:10.1093/ejcts/ezu201
M.H. Kulke, T. O’Dorisio, A. Phan, E. Bergsland, L. Law, P. Banks, J. Freiman, K. Frazier, J. Jackson, J.C. Yao, L. Kvols, P. Lapuerta, B. Zambrowicz, D. Fleming, A. Sands, Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide. Endocr. Relat. Cancer 21(5), 705–714 (2014). doi:10.1530/ERC-14-0173
B. Sareyyupoglu, H.M. Connolly, H.V. Schaff, Surgical excision of right ventricular carcinoid tumor in a symptomatic patient without carcinoid valve disease. J. Thorac. Cardiovasc. Surg. 140(2), e23–e25 (2010). doi:10.1016/j.jtcvs.2009.07.072
H.B. Fiebrich, A.H. Brouwers, T.P. Links, E.G. de Vries, Images in cardiovascular medicine: myocardial metastases of carcinoid visualized by 18F-dihydroxy-phenyl-alanine positron emission tomography. Circulation 118(15), 1602–1604 (2008). doi:10.1161/CIRCULATIONAHA.108.767111
Acknowledgments
We thank Associate Professor Anders Höög for kindly providing Figs. 1 and 2. We also thank Professor Kenneth Caidal for valuable comments. This study was supported by the Magn. Bergvalls Foundation, the Swedish Endocrine Society, the Karolinska Institute and Stockholm County Council.
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Calissendorff, J., Maret, E., Sundin, A. et al. Ileal neuroendocrine tumors and heart: not only valvular consequences. Endocrine 48, 743–755 (2015). https://doi.org/10.1007/s12020-014-0446-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12020-014-0446-0