Skip to main content

Advertisement

SpringerLink
Log in

Chronic MCH infusion causes a decrease in energy expenditure and body temperature, and an increase in serum IGF-1 levels in mice

  • Original Article
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Melanin concentrating hormone (MCH) is an orexigenic peptide secreted from the lateral hypothalamus. Various observations suggest a role for MCH in energy expenditure in transgenic mice; however, the influence of MCH on energy expenditure and body temperature in WT mice was inadequately studied. Therefore, our first goal was to characterize the influence of chronic intracerebroventrical MCH infusion on energy homeostasis in mice. Our second goal was to explore the effect of MCH on the GH–insulin like growth factor 1 (IGF-1) axis in vivo. We have recently published that MCH directly increased GH-secretion from pituitary cells in vitro, suggesting that MCH may exert part of its effects on energy balance via direct pituitary hormone regulation. Mice were centrally infused with MCH for 14 days, resulting in a significant increase in food intake, body weight, fat mass and plasma IGF-1 levels, while decreasing body temperature and energy expenditure. Our data emphasize the role of MCH as a key regulator of energy homeostasis by means of appetite regulation, regulation of energy expenditure, and an integrator of energy balance with the neuroendocrine system regulating pituitary hormone secretion. They also support the notion that MCH may have a physiologic role in GH regulation that may, in turn, contribute to its effect on body weight.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. G. Rivera, V. Bocanegra-Garcia, S. Galiano, N. Cirauqui, J. Ceras, S. Perez, I. Aldana, A. Monge, Curr. Med. Chem. 15, 1025–1043 (2008)

    Article  CAS  PubMed  Google Scholar 

  2. P. Pissios, R.L. Bradley, E. Maratos-Flier, Endocr. Rev. 27, 606–620 (2006)

    Article  CAS  PubMed  Google Scholar 

  3. D.Q. Qu, D.S. Ludwig, S. Gammeltoft, M. Piper, M.A. Pelleymounter, M.J. Cullen, W.F. Mathes, J. Przypek, R. Kanarek, E. MaratosFlier, Nature 380, 243–247 (1996)

    Article  CAS  PubMed  Google Scholar 

  4. M. Rossi, C.J. Small, A.P. Goldstone, M.A. Ghatei, S.R. Bloom, Diabetologia 40, 1054 (1997)

    Google Scholar 

  5. M. Rossi, S.J. Choi, D. Oshea, T. Miyoshi, M.A. Ghatei, S.R. Bloom, Endocrinology 138, 351–355 (1997)

    Article  CAS  PubMed  Google Scholar 

  6. O. Della-Zuana, F. Presse, C. Ortola, J. Duhault, J.L. Nahon, N. Levens, Int. J. Obes. 26, 1289–1295 (2002)

    Article  CAS  Google Scholar 

  7. B. Guesdon, E. Paradis, P. Samson, D. Richard, Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R469–R475 (2009)

    CAS  PubMed  Google Scholar 

  8. B. Borowsky, M.M. Durkin, K. Ogozalek, M.R. Marzabadi, J. DeLeon, R. Heurich, H. Lichtblau, Z. Shaposhnik, I. Daniewska, T.P. Blackburn, T.A. Branchek, C. Gerald, P.J. Vaysse, C. Forray, Nat. Med. 8, 825–830 (2002)

    CAS  PubMed  Google Scholar 

  9. M.M. Messina, J.M. Overton, Regul. Pept. 139, 23–30 (2007)

    Article  CAS  PubMed  Google Scholar 

  10. M. Ito, A. Gomori, A. Ishihara, Z. Oda, S. Mashiko, H. Matsushita, M. Yumoto, H. Sano, S. Tokita, M. Moriya, H. Iwaasa, A. Kanatani, Am. J. Physiol. Endocrinol. Metab. 284, E940–E945 (2003)

    CAS  PubMed  Google Scholar 

  11. A. Gomori, A. Ishihara, M. Ito, S. Mashiko, H. Matsushita, M. Yumoto, T. Tanaka, S. Tokita, M. Moriya, H. Iwaasa, A. Kanatani, Am. J. Physiol. Endocrinol. Metab. 284, E583–E588 (2003)

    CAS  PubMed  Google Scholar 

  12. B.K. Whitlock, J.A. Daniel, C.D. McMahon, F.C. Buonomo, C.G. Wagner, B. Steele, J.L. Sartin, Domest. Anim. Endocrinol. 28, 224–232 (2005)

    Article  CAS  PubMed  Google Scholar 

  13. M. Shimada, N.A. Tritos, B.B. Lowell, J.S. Flier, E. Maratos-Flier, Nature 396, 670–674 (1998)

    Article  CAS  PubMed  Google Scholar 

  14. D.J. Marsh, D.T. Weingarth, D.E. Novi, H.Y. Chen, M.E. Trumbauer, A.S. Chen, X.M. Guan, M.M. Jiang, Y. Feng, R.E. Camacho, Z. Shen, E.G. Frazier, H. Yu, J.M. Metzger, S.I. Kuca, L.P. Shearman, S. Gopal-Truter, D.J. MacNeil, A.M. Strack, D.E. MacIntyre, L.H.T. Van der Ploeg, S. Qian, Proc. Natl Acad. Sci. U S A 99, 3240–3245 (2002)

    Google Scholar 

  15. Y.Y. Chen, C.Z. Hu, C.K. Hsu, Q. Zhang, C. Bi, M. Asnicar, H.M. Hsiung, N. Fox, L.J. Slieker, D.D. Yang, M.L. Heiman, Y.G. Shi, Endocrinology 143, 2469–2477 (2002)

    Article  CAS  PubMed  Google Scholar 

  16. G. Segal-Lieberman, R.L. Bradley, E. Kokkotou, M. Carlson, D.J. Trombly, X.M. Wang, S. Bates, M.G. Myers, J.S. Flier, E. Maratos-Flier, Proc. Natl Acad. Sci. U S A 100, 10085–10090 (2003)

    Google Scholar 

  17. G. Segal-Lieberman, H. Rubinfeld, M. Glick, N. Kronfeld-Schor, I. Shimon, Am. J. Physiol. Endocrinol. Metab. 290, E982–E988 (2006)

    Article  CAS  PubMed  Google Scholar 

  18. Y. Saito, H.P. Nothacker, Z.W. Wang, S.H.S. Lin, F. Leslie, O. Civelli, Nature 400, 265–269 (1999)

    Article  CAS  PubMed  Google Scholar 

  19. K. Takahashi, K. Totsune, O. Murakami, N. Sone, F. Satoh, T. Kitamuro, T. Noshiro, Y. Hayashi, H. Sasano, S. Shibahara, J. Clin. Endocrinol. Metab. 86, 369–374 (2001)

    Article  CAS  PubMed  Google Scholar 

  20. V. Cvetkovic, F. Brischoux, B. Griffond, G. Bernard, C. Jacquemard, D. Fellmann, P.Y. Risold, Neuroscience 116, 31–35 (2003)

    Article  CAS  PubMed  Google Scholar 

  21. J.C. Bittencourt, F. Presse, C. Arias, C. Peto, J. Vaughan, J.L. Nahon, W. Vale, P.E. Sawchenko, J. Comp. Neurol. 319, 218–245 (1992)

    Article  CAS  PubMed  Google Scholar 

  22. A.R. Kennedy, J.F. Todd, S.A. Stanley, C.R. Abbott, C.J. Small, M.A. Ghatei, S.R. Bloom, Endocrinology 142, 3265–3268 (2001)

    Article  CAS  PubMed  Google Scholar 

  23. A.R. Kennedy, J.F. Todd, W.S. Dhillo, L.J. Seal, M.A. Ghatei, C.P. O’Toole, M. Jones, D. Witty, K. Winborne, G. Riley, G. Hervieu, S. Wilson, S.R. Bloom, J. Neuroendocrinol. 15, 268–272 (2003)

    Article  CAS  PubMed  Google Scholar 

  24. M. Bjursell, E. Egecioglu, A.K. Gerdin, L. Svensson, J. Oscarsson, D. Morgan, M. Snaith, J. Tornell, Y.M. Bohlooly, Biochem. Biophys. Res. Commun. 326, 759–765 (2005)

    Article  CAS  PubMed  Google Scholar 

  25. D.S. Ludwig, N.A. Tritos, J.W. Mastaitis, R. Kulkarni, E. Kokkotou, J. Elmquist, B. Lowell, J.S. Flier, E. Maratos-Flier, J. Clin. Invest. 107, 379–386 (2001)

    Article  CAS  PubMed  Google Scholar 

  26. E. Kokkotou, J.Y. Jeon, X.M. Wang, F.E. Marino, M. Carlson, D.J. Trombly, E. Maratos-Flier, Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, R117–R124 (2005)

    CAS  PubMed  Google Scholar 

  27. B.J. Oldfield, M.E. Giles, A. Watson, C. Anderson, L.M. Colvill, M.J. McKinley, Neuroscience 110, 515–526 (2002)

    Article  CAS  PubMed  Google Scholar 

  28. M. Pereira-da-Silva, M. Torsoni, H.V. Nourani, V.D. Augusto, C. Souza, A.L. Gasparetti, J. Carvalheira, G. Ventrucci, M. Marcondes, A.P. Cruz-Neto, M.J.A. Saad, A.C. Boschero, E.M. Carneiro, L. Velloso, Endocrinology 144, 4831–4840 (2003)

    Article  CAS  PubMed  Google Scholar 

  29. M.J. Stock, Proc. Nutr. Soc. 48, 189–196 (1989)

    Google Scholar 

  30. N.J. Rothwell, M.J. Stock, Obes. Res. 5, 650–656 (1997)

    CAS  PubMed  Google Scholar 

  31. J.T. Willie, C.M. Sinton, E. Maratos-Flier, M. Yanagisawa, Neuroscience 156, 819–829 (2008)

    Article  CAS  PubMed  Google Scholar 

  32. A. Iranmanesh, G. Lizarralde, J.D. Veldhuis, J. Clin. Endocrinol. Metab. 73, 1081–1088 (1991)

    Article  CAS  PubMed  Google Scholar 

  33. Y.M. Bohlooly, M. Mahlapuu, H. Andersen, A. Astrand, S. Hjorth, L. Svensson, J. Tornell, M.R. Snaith, D.G. Morgan, C. Ohlsson, Biochem. Biophys. Res. Commun. 318, 964–969 (2004)

    Article  Google Scholar 

  34. F. Depocas, J.S. Hart, J. Appl. Physiol. 20, 261–263 (1957)

    Google Scholar 

  35. P.C. Withers, J. Appl. Physiol. Respirat. Environ. Exerc. Physiol. 42, 120–123 (1977)

    CAS  Google Scholar 

Download references

Acknowledgments

We thank Dr. Hadara Rubinfeld for her generous assistance. This study was supported by a grant from the United States-Israel Binational Science Foundation, Jerusalem, Israel, to G. Segal-Lieberman (Grant no. 2001160).

Author information

Authors and Affiliations

  1. Department of Zoology, Tel Aviv University, Tel Aviv, 69978, Israel

    Moran Glick, Rotem Cohen & Noga Kronfeld-Schor

  2. Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, 52621, Israel

    Gabriella Segal-Lieberman

Authors
  1. Moran Glick
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gabriella Segal-Lieberman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rotem Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Noga Kronfeld-Schor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Noga Kronfeld-Schor.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Glick, M., Segal-Lieberman, G., Cohen, R. et al. Chronic MCH infusion causes a decrease in energy expenditure and body temperature, and an increase in serum IGF-1 levels in mice. Endocr 36, 479–485 (2009). https://doi.org/10.1007/s12020-009-9252-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-009-9252-5

Keywords

Search

Navigation