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SUMO Rules: Regulatory Concepts and Their Implication in Neurologic Functions

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Abstract

Posttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a potent regulator of various cellular events. Hundreds of substrates have been identified, many of them involved in vital processes like transcriptional regulation, signal transduction, protein degradation, cell cycle regulation, DNA repair, chromatin organization, and nuclear transport. In recent years, protein sumoylation increasingly attracted attention, as it could be linked to heart failure, cancer, and neurodegeneration. However, underlying mechanisms involving how modification by SUMO contributes to disease development are still scarce thus necessitating further research. This review aims to critically discuss currently available concepts of the SUMO pathway, thereby highlighting regulation in the healthy versus diseased organism, focusing on neurologic aspects. Better understanding of differential regulation in health and disease may finally allow to uncover pathogenic mechanisms and contribute to the development of disease-specific therapies.

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Acknowledgments

We thank all Pichler laboratory members for critical reading of the manuscript. The work in the Pichler laboratory is funded by the Max Planck Society, the Deutsche Forschungsgemeinschaft (DFG, PI 917/1-1, DFG-SPP1365 PI 917/2-1) and the Fritz Thyssen Stiftung (10.11.1.210).

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The authors declare that there is no conflict of interest.

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  1. Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108, Freiburg, Germany

    Mathias Droescher, Viduth K. Chaugule & Andrea Pichler

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  1. Mathias Droescher
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Droescher, M., Chaugule, V.K. & Pichler, A. SUMO Rules: Regulatory Concepts and Their Implication in Neurologic Functions. Neuromol Med 15, 639–660 (2013). https://doi.org/10.1007/s12017-013-8258-6

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