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Atopic Dermatitis and the Nervous System

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Abstract

Due to the narrow associations between the skin, immune system, and nervous system, nerve endings are very important in the pathophysiology of inflammatory dermatoses and especially in atopic dermatitis. Many neurotransmitters and nerve growth factors that are released in blood or skin are involved in neurogenic inflammation, which dramatically enhance the inflammation induced by immune cells. During times of stress, their release is highly enhanced. In atopic dermatitis lesions, there are many specific changes in skin neurobiology and neurophysiology. These interesting data suggest that novel therapeutic possibilities can be imagined.

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  1. University of Brest, Brest, France

    Laurent Misery

  2. Department of Dermatology and Laboratory of Skin Neurobiology, University Hospital, 29609, Brest, France

    Laurent Misery

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Misery, L. Atopic Dermatitis and the Nervous System. Clinic Rev Allerg Immunol 41, 259–266 (2011). https://doi.org/10.1007/s12016-010-8225-z

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