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Intrinsically Disordered Regions in Serum Albumin: What Are They For?

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Abstract

Serum albumin is a major plasma protein in mammalian blood. The importance of this protein lies in its roles in both bioregulation and transport phenomena. Serum albumin binds various metal ions and participates in the transport and storage of fatty acids, bilirubin, steroids amino acids, and many other ligands, usually with regions of hydrophobic surface. Although the primary role of serum albumin is to transport various ligand, its versatile binding capacities and high concentration mean that it can assume a number of additional functions. The major goal of this article is to show how intrinsic disorder is encoded in the amino acid sequence of serum albumin, and how intrinsic disorder is related to functions of this important serum protein.

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Acknowledgements

This work was supported by a Grant No 16-34-60229 from the Russian Foundation for Basic Research (E.A.L.).

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Authors and Affiliations

  1. Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, 142290, Moscow Region, Russia

    Ekaterina A. Litus, Sergei E. Permyakov, Vladimir N. Uversky & Eugene A. Permyakov

  2. Department of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, 33612, FL, USA

    Vladimir N. Uversky

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  1. Ekaterina A. Litus
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  2. Sergei E. Permyakov
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  3. Vladimir N. Uversky
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  4. Eugene A. Permyakov
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Correspondence to Eugene A. Permyakov.

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Litus, E.A., Permyakov, S.E., Uversky, V.N. et al. Intrinsically Disordered Regions in Serum Albumin: What Are They For?. Cell Biochem Biophys 76, 39–57 (2018). https://doi.org/10.1007/s12013-017-0785-6

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